CAS: 35597-44-5; L-Phosphinothricin

上下游产品

草胺膦 Dl-Homoalanin-4-Yl(Methyl)Phosphinic Acid 51276-47-2
(S)-2-Amino-4-(Ethoxy-Methyl-Phosphinoyl)-Butyric Acid 128574-46-9
2-羰基-4-(羟基甲基膦酰基)丁酸 2-Oxo-4-[(Hydroxy)(Methyl)Phosphinoyl]Butyric Acid 79778-02-2

📜(S)-2-Amino-4-(Ethoxy-Methyl-Phosphinoyl)-Butyric Acid置于盐酸体系中,用 甲醇 作为反应溶剂,以34.3 G的收率获得产物[(3S)-3-氨基-4-羟基-4-氧代丁基]-(羟基甲基)-氧代鏻
参考文献:一种l-草铵膦的合成方法
标题:一种l-草铵膦的合成方法
摘要:本发明涉及农药生产技术领域,具体公开一种l‑草铵膦的合成方法.所述合成方法包括:醇溶剂中,L‑高丝氨酸与氯化试剂反应,得化合物ⅲ;醇溶剂中,化合物ⅲ与甲基亚膦酸二乙酯进行膦酰化反应,得化合物ⅳ;化合物ⅳ于酸性条件下水解,得l‑草铵膦盐酸盐溶液,将l‑草铵膦盐酸盐溶液经后处理得到l‑草铵膦.本发明提供的l‑草铵膦的合成方法,有效简化了l‑草铵膦的合成工艺,提高了生产效率,且减少了原料种类,制备成本显著降低,产品的总收率可达90%以上,纯度可达97%以上,且三废产生量少,适合大规模工业化生产应用,对草铵膦类农药的发展具有十分重要的意义.

专利信息

专利号:EP-1309698-B1
优先权日:2000-07-21
标 题:A cytochrome p450 enzyme associated with the synthesis of delta-12 -epoxy groups in fatty acids of plants
发明人：CAHOON EDGAR B
权利人:DU PONT
摘要:An isolated nucleic acid fragment encoding a cytochrome P450 enzyme associated with the synthesis of plant DELTA12-epoxy fatty acids is disclosed. The invention also relates to making a chimeric construct encoding all or a portion of the cytochrome P450 enzymes associated with the synthesis of plant DELTA12-epoxy fatty acids, in sense or antisense orientation, wherein expression of the chimeric construct results in production of altered levels of the cytochrome P450 enzymes associated with the synthesis of plant DELTA12-epoxy fatty acids in a transformed host cell.

专利号:US-2024110196-A1
优先权日:2022-08-29
标题 :Use of multigene stacking method in synthesis of nervonic acid in brassica napus
发明人：LIU FANG; WANG PANDI; WU GANG; XIONG XIAOJUAN
权利人:OIL CROPS RES INSTITUTE CAAS
摘要:The present disclosure relates to use of a multigene stacking method in synthesis of nervonic acid in Brassica napus. The present disclosure provides a multigene co-expression plant vector, including an initial backbone of pBWA(V)BII and multiple exogenous gene expression cassettes. The present disclosure further provides two plant vectors applicable to genetic transformation, including a three-gene co-expression plant vector and a five-gene co-expression plant vector. In the present disclosure, after the three-gene co-expression plant vector and the five-gene co-expression plant vector are separately transferred into the Brassica napus, the nervonic acid (NA) with a high content is synthesized in the Brassica napus through multigene co-expression. An NA ratio can be significantly increased combined with a higher seed oil content and a greater field seed yield. The plant vector realizes efficient synthesis of NA in oil crops, obtains NA-rich seed oil, and increases an added value of edible oil.

专利号:US-2025019732-A1
优先权日:2023-07-07
标 题:Method for chemical-biological cascade synthesis of l-phosphinothricin and mutants therefor
发明人：XUE YAPING; CHENG FENG; ZOU SHUPING; XU JIANMIAO; ZHENG YUGUO
权利人:UNIV ZHEJIANG TECHNOLOGY
摘要:A method for chemical-biological cascade synthesis of L-phosphinothricin is carried out as follows: 3-(methylethoxyphosphinyl) ethyl propionate is synthesized by addition reaction from diethoxymethylphosphine and acrylic acid, then a condensation reaction is carried out with 3-(methylethoxyphosphinyl) ethyl propionate and sodium ethoxide as reactants, then the product is subjected to a hydrolysis reaction with diethyl oxalate to synthesize 4-(hydroxymethylphosphinyl)-2-oxobutyric acid, and finally, L-phosphinothricin is catalytically synthesized by taking 4-(hydroxymethylphosphinyl)-2-oxobutyric acid as a raw material, and using highly active and stable wet cells co-expressing phsophinothricin dehydrogenase and alcohol dehydrogenase or co-expressing a phsophinothricin dehydrogenase mutant and alcohol dehydrogenase as a biocatalyst, thereby solving the problems of existing L-phosphinothricin synthesis being tedious, low asymmetric amination reduction activity and poor stability.

专利号:US-12146136-B2
优先权日:2020-03-26
标题:Synthesis of modified oligonucleotides with increased stability
发明人：KHVOROVA ANASTASIA; ROUX LOÃ?C MAURICE RENÉ JEAN; YAMADA KEN
权利人:UNIV MASSACHUSETTS
摘要:This disclosure relates to the synthesis of novel modified oligonucleotides. The synthesis of novel phosphoramidites are also provided.

专利号:WO-2024010785-A1
优先权日:2022-07-08
标 题:Ketoreductase enzymes for the synthesis of 1,3-diol substituted indanes
发明人：CAHN JACKSON KENAI BLENDER; CHEUNG-LEE WAI LING; CHUN STEPHANIE W; HIRAGA KAORI; KOSJEK BIRGIT; KNIGHT JOHN H; MAKAREWICZ AMANDA M; MCCANN SCOTT; MOORE JEFFREY C; VERMA DEEPTAK
权利人:MERCK SHARP & DOHME LLC
摘要:The present disclosure provides ketoreductase enzymes having improved enzymatic properties including the capability of reducing hydroxy indanones to provide diastereomerically pure 1,3-indane diols useful for the synthesis of belzutifan. Also provided are polynucleotides encoding the ketoreductase enzymes, and host cells capable of expressing the ketoreductase enzymes. A purification procedure for isolating the ketoreductase enzymes is also provided.

专利号:US-2025215464-A1
优先权日:2022-07-08
标题 :Engineered enzyme for preparing a hydroxylated indanone intermediate useful in the synthesis of belzutifan
发明人：CHEUNG-LEE WAI LING; DIROCCO DANIEL A; GIL AGNIESZKA; HIRAGA KAORI; KIM JUNGCHUL; KOLEV JOSHUA; KOSJEK BIRGIT; MALONEY KEVIN M; SALEHI MARZIJARANI NASTARAN; MCINTOSH JOHN; MCMULLEN JONATHAN P; MOORE JEFFREY C; MURPHY GRANT S; PAN WEILAN; VELASQUEZ VELEZ JUAN E; VERMA DEEPTAK; WINSTON MATTHEW S; XIAO LI; ZHANG VICTORIA
权利人:MERCK SHARP & DOHME LLC
摘要:The present disclosure provides enzymes derived from the fungi Fusarium oxysporum c8D (“FoPip4H enzymesâ€?) having improved properties as compared to a naturally occurring wild-type enzyme including the capability of hydroxylating certain substituted indanones to provide optically pure 3-hydroxyindanones. Also provided are polynucleotides encoding the FoPip4H enzymes, host cells capable of expressing the FoPip4H enzymes, and processes for using the FoPip4H enzymes to synthesize (R)-4-fluoro-3-hydroxy-7-(methylsulfonyl)-2, 3-dihydro-1H-inden-1-one, a useful intermediate in the synthesis of belzutifan.