CAS: 30148-21-1; Ethyl 1-Methyl-1H-Imidazole-2-Carboxylate

相似化合物

13750-81-7 17334-08-6 20485-43-2

上下游产品

CAS号616-47-7 N-甲基咪唑 | CAS号541-41-3 氯甲酸乙酯 | CAS号109-94-4 甲酸乙酯 | CAS号35342-89-3 1-METHYL-2-(TRI... | CAS号109012-46-6 1H-Imidazole-2-... | CAS号20062-51-5 1-Methyl-1H-imi... | CAS号616-47-7 N-甲基咪唑 | CAS号17334-08-6 1-甲基-2-羟甲基-1H-咪唑 | CAS号141-97-9 乙酰乙酸乙酯 | CAS号109012-23-9 1-甲基-4-硝基咪唑-2-羧酸乙酯 | CAS号109012-22-8 ethyl 1-methyl-... | CAS号1564-49-4 1-甲基-5-硝基-1H-咪唑... | CAS号33543-79-2 1-甲基-1H-咪唑-2-碳酰肼

📜N-甲基咪唑,氯甲酸乙酯置于正丁基锂,三甲基氯硅烷体系中,用 四氢呋喃,正己烷 用作溶剂,化学反应 2.5H,以37%的收率获得1-甲基-1H-咪唑-2-甲酸乙酯
参考文献:一锅顺序溴化和sonogashira交叉偶联对咪唑的高度区域选择性c-5烷基化
标题:一锅顺序溴化和sonogashira交叉偶联对咪唑的高度区域选择性c-5烷基化
摘要:可通过一锅顺序程序轻松制备各种2取代的5-炔基-1 H-咪唑,该程序涉及1,2-二甲基-1 H-咪唑,2-氯-1的高度区域选择性亲电c-5溴化反应-甲基-1 H-咪唑和2-芳基-1-甲基-1 H-咪唑,然后进行有效的钯/铜共催化的sonogashira型炔基化反应.
Doi:10.1016/j.Tetlet.2015.04.094

专利信息

专利号:US-6683189-B1
优先权日:1996-02-26
标 题 :Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
发明人：DERVAN PETER B; BAIRD ELDON
权利人:CALIFORNIA INST OF TECHN
摘要:The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise coupling yields (>99%), providing milligram quantities of highly pure polyamides. The present invention also describes the synthesis of analogs of the natural products Netropsin and Distamycin A, two antiviral antibiotics. The present invention also describes a novel method for the solid phase synthesis of imidazole and pyrrole carboxamide polyamide-oligonucleotide conjugates. This methodology will greatly increase both the complexity and quantity of minor-groove binding polyamides and minor-groove binding polyamide-oligonucleotide conjugates which can be synthesized and tested.

专利号:US-2025163020-A1
优先权日:2022-08-31
标 题:Chiral Synthesis of Nornicotine and Nicotine
发明人：STRAKOVÃ? KAROLÃ?NA; MÃœLLER DOMINIK SIMON; VAN VEGTEN CORNELIS HENDRIK; ZELLER FLORIAN DANIEL; DEBNAR THOMAS
权利人:SIEGFRIED AG; CONTRAF NICOTEX TOBACCO GMBH
摘要:The present invention relates to a method of producing nornicotine through enantioselective hydrosilylation of myosmine and a composition produced thereby, as well as a composition comprising nornicotine and a catalyst, wherein the catalyst is an organic chiral Lewis base, and a catalyst. The present invention also relates to a method of producing nicotine or a salt thereof from myosmine through enantioselective hydrosilylation of myosmine to nornicotine and further reacting the nornicotine to nicotine or a salt thereof, and a composition produced thereby, as well as a composition comprising nicotine, or a salt thereof, and a catalyst, wherein the catalyst.

专利号:US-6545162-B1
优先权日:1996-02-26
标 题:Method for the synthesis of pyrrole and imidazole carboxamides on a solid support

专利号:EP-4540239-A1
优先权日:2022-08-31
标题 :Chiral synthesis of nornicotine and nicotine

专利号:WO-9730975-A2
优先权日:1996-02-26
标题:Method for the synthesis of poly-pyrrole and poly-imidazole carboxamides on a solid support

专利号:EP-4332098-A1
优先权日:2022-08-31
标题:Chiral synthesis of nornicotine and nicotine