CAS: 2886-65-9; 7-Chloro-5-(2-Fluorophenyl)-1,3-Dihydro-2H-1,4-Benzodiazepin-2-One

上下游产品

氟西泮 Flurazepam 17617-23-1
7-氯-1,3-二氢-5-(2-氟苯基)-2-硝基亚甲基-2H-1,4-苯并二氮杂卓 7-Chloro-5-(2-Fluorophenyl)-2-Nitromethylene-1,3-Dihydro-2H-1,4-Benzodiazepine 59467-63-9
2-溴乙酰氨基-5-氯-2’-氟二苯甲酮 2-(2-Bromoacetamido)-5-Chloro-2'-Fluorobenzophenone 1584-62-9
2-氯-N-[4-氯-2-(2-氟苯基)苯基]乙酰胺 2-Chloracetylamino-5-Chlor-2'-Fluor-Benzophenon 2836-40-0

📜2-氨基-5-氯-2'-氟二苯甲酮置于盐酸,溶剂黄146,N,N'-二环己基碳二亚胺体系中,用 二氯甲烷,水,异丙醇 用作溶剂,化学反应 36.0H,反应生成7-氯-5-(2-氟苯基)-1,3-二氢-3H-1,4-苯并二氮杂卓-2-酮
参考文献:One-Pot Microwave-Assisted Synthesis And Antimalarial Activity Of Ferrocenyl Benzodiazepines
标题:One-Pot Microwave-Assisted Synthesis And Antimalarial Activity Of Ferrocenyl Benzodiazepines
摘要:描述了一种高效合成1,4-苯二氮䓬-2-酮的方法,该方法通过微波辅助照射使2-氨基苯基酮与boc保护的氨基酸缩合.这种方法相比传统方法在较短的反应时间内产生更高的收率.相应的铁杂环苯二氮䓬的抗疟活性在体外对抗疟原虫福32株(对氯喹敏感)及fcb1和k1(对氯喹耐药)株,以及加蓬临床分离株进行了评估.
Doi:10.1039/c1Nj20551J

专利信息

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-4118386-A
优先权日:1977-04-04
标 题:Synthesis of imidazo[1,5-a]diazepine-3-carboxylates
发明人：WALSER ARMIN
权利人:HOFFMANN LA ROCHE
摘要:A process to produce diazepine-3-carboxylates of the formula ##STR1## is selected from the group consisting of ##STR2## R 6 is selected from the group consisting of hydrogen, halogen, nitro, cyano, trifluoromethyl, lower alkyl, and lower alkanoyl; n R 4 is lower alkyl; R 3 is selected from the group consisting of phenyl, mono-substituted phenyl, disubstituted phenyl, pyridyl and mono-substituted pyridyl; and R 2 is hydrogen or lower alkyl which comprises reacting a compound of the formula ##STR3## wherein R 1 is of the formula ##STR4## AND R 5 is lower alkyl with a compound of the formula n n Nâ•?C-CH.sub.2 --COOR.sub.4 n n in the presence of a base sufficiently strong to generate the anion of the isocyanoacetate.

专利号:EP-1105392-B1
优先权日:1999-06-30
标 题:Process for the preparation of imidazodiazepine intermediates
发明人：DHAON MADHUP K; LABIB PARVIS; DAVIS DEBORAH A; ESSER GRANT L
权利人:ABBOTT LAB
摘要:The present invention relates to a process for the synthesis of a compound having formula XI, from a compound of formula X.