CAS: 2873-18-9; 2-Bromo-5-Chlorothiophene

上下游产品

CAS号96-43-5 2-氯噻吩 | CAS号1003-09-4 2-溴噻吩 | CAS号36155-88-1 3-bromo-4-chlor... | CAS号32431-92-8 5-Brom-3-chlort... | CAS号32431-93-9 4-溴-2-氯噻吩 | CAS号50478-16-5 5-氯-2-噻吩甲腈 | CAS号18853-40-2 2,5-二氰基噻吩 | CAS号96-43-5 2-氯噻吩 | CAS号18494-75-2 5,5'-dichloro-2... | CAS号24065-33-6 2-氯噻吩-5-甲酸 | CAS号5751-82-6 5-氯硫代苯-2-甲酸乙酯 | CAS号22237-13-4 4-乙氧基苯硼酸

2-溴噻吩置于n-氯代丁二酰亚胺,高氯酸体系中,用 氯仿 用作溶剂,化学反应 1.0H,以75%的收率获得2-溴-5-氯噻吩
参考文献:Synthesis And Structural Characterization Of 2,5-Dihalo-3,4-Dinitrothiophenes
标题:Synthesis And Structural Characterization Of 2,5-Dihalo-3,4-Dinitrothiophenes
摘要:通过使用新的硝化方案,我们能够高效地对 2,5-二卤噻吩进行二硝化反应,产率可达 ∼ 80-95%.所得产物 2,5-二溴-3,4-二硝基噻吩 (1),2,5-二氯-3,4-二硝基噻吩 (2),2-溴-5-氯-3,4-二硝基噻吩 (3) 以及类似的 2-溴-3,4-二硝基噻吩 (4),都很容易结晶,可以通过 X 射线晶体学进行表征.1 结晶于单斜空间群 C2/c,A = 14.547(3) 埃,B = 7.3534(15) 埃,C = 10.775(2) 埃,β = 128.89(3)°,Z = 4.2置于i-42D 四方空间群中结晶,A = 9.9398(14) 埃,B = 9.9398(14) 埃,C = 16.866(3) 埃,Z = 8.3 在三菱空间群 P-1 中结晶为假正四面体孪晶,A = 7.340(5) 埃,B = 8.094(5) 埃,C = 9.4 在三菱空间群 P-1 中结晶,A = 7.1787(14) 埃,B = 7.4092(15) 埃,C = 8.3151(17) 埃,α = 101.67(3)°,β = 96.00(3)°,γ = 116.13(3)°,Z = 2.由于卤素和硝基之间的卤键相互作用,所有化合物的结构都显示出形成了有趣的固态组合体.
Doi:10.1007/s10870-006-9160-Y

专利信息

专利号:US-2025179012-A1
优先权日:2022-03-04
标 题:Synthesis of sulfur(vi) compounds and reagents for same
发明人：LOPCHUK JUSTIN MATTHEW; SHULTZ ZACHARY
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure provides reagents and processes for the synthesis of organic compounds, more particularly reagents and processes for the asymmetric synthesis of sulfur (VI) containing organic compounds.

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:WO-2023168108-A2
优先权日:2022-03-04
标 题 :Synthesis of sulfur(vi) compounds and reagents for same

专利号:CN-108840854-B
优先权日:2018-09-18
标 题 :A kind of method for one-pot synthesis of 5-chlorothiophene-2-carboxylic acid

专利号:US-2009137557-A1
优先权日:2005-11-22
标题 :Calcilytic Compounds
发明人：KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
权利人:KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.