📜Benzolsulfonyl-Oxamoylchlorid置于邻二氯苯体系中,化学反应生成异氰酸苯磺酰酯 参考文献:The Reactions Of Sulfonamides With Oxalyl Chloride 标题:The Reactions Of Sulfonamides With Oxalyl Chloride 摘要: Doi:10.1021/jo01032A025
专利号:US-2004028702-A1 优先权日:2002-07-26 标 题:Muramic acid derivative compounds 发明人:MALETIC MILANA M; LEEMAN AARON H; SANTORELLI GINA M; WADDELL SHERMAN T 摘要:The present invention pertains to the combinatorial synthesis of antibacterial agents that inhibit the Mur-pathway enzymes involved in bacterial cell wall assembly. The method uses p-alkoxybenzylidene as the linker for the attachment of a derivatized muramic acid to the polymeric resin support. This intermediate becomes the starting point for the combinatorial synthesis, which in conjunction with split-pooling techniques allows rapid synthesis of diverse analogues for high-throughput screening (HTS). The invention is further directed to the libraries of these finished compounds that vary at the peptide, N-acyl and anomeric UDP positions.
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专利号:US-5521179-A 优先权日:1991-04-18 标题 :Heterocyclic amides 发明人:BERNSTEIN PETER R; SHAW ANDREW; THOMAS ROYSTON M; WARNER PETER; WOLANIN DONALD J 权利人:ZENECA LTD 摘要:The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic amides, processes for preparing the heterocyclic amides, pharmaceutical compositions containing such heterocyclic amides and methods for their use.
专利号:WO-2006043121-A1 优先权日:2004-10-20 标 题:Oxazolidinone derivatives as antimicrobials 发明人:MEHTA ANITA; DAS BISWAJIT; RUDRA SONALI; YADAV AJAY SINGH; KUMARI SANGITA; SALMAN MOHAMMAD; RATTAN ASHOK 权利人:RANBAXY LAB LTD; MEHTA ANITA; DAS BISWAJIT; RUDRA SONALI; YADAV AJAY SINGH; KUMARI SANGITA; SALMAN MOHAMMAD; RATTAN ASHOK 摘要:The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.