CAS: 270065-76-4; (S)-3-Amino-4-(3-(Trifluoromethyl)Phenyl)Butanoic Acid
该化合物是一种含氟苯丙烯衍生物,其主脊为同苯丙烯,三氟甲基组位于三点,该化合物主要用于合成和药用化学研究,因为三氟甲基替代品提高了代谢稳定性和亲脂性.盐形式的盐可以确保合成应用中的溶解性和处理能力得到改善.其结构特征使得它对于研究酶基体相互作用,特别是在蛋白抑制剂和药物设计方面,具有价值.该化合物的脊髓纯度(L-配置)对于维持生物活性的细胞选择性至关重要.它是一个多用途建筑,用于开发有定制的药用活性皮革特性的氟模拟.
- 英文名称(S)-3-Amino-4-(3-(Trifluoromethyl)Phenyl)Butanoic Acid
- 中文名称(S)-3-氨基-4-(3-(三氟甲基)苯基)丁酸
- 其它别名(S)-3-氨基-4-(3-三氟甲基苯基)丁酸; (S)-3-Amino-4-(3-Trifluoromethyl-Phenyl)-Butyric Acid-Hcl
- CAS编号270065-76-4
- MFCD编号:MFCD01861066
- 分子式:C11H12F3NO2分子量:247.21
- 产品CID: 1249778
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2905130000-正丁醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2022243244-A1
优先权日:2019-10-10
标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
发明人：ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
权利人:SCRIPPS RESEARCH INST
摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.
专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.
专利号:US-2025084410-A1
优先权日:2015-01-12
标 题:Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
权利人:SYNTHORX INC
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.
专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.
专利号:WO-2021072167-A1
优先权日:2019-10-10
标 题:Compositions and methods for in vivo synthesis of unnatural polypeptides
专利号:US-11091522-B2
优先权日:2018-07-23
标题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.
