CAS: 24673-56-1; 3-Methylbenzofuran-2-Carboxylic Acid

该化合物是一种有机化合物,其特征是其引信的苯并呋喃结构,由苯环组成,与呋喃环结合,以及一个碳本体酸功能组,该化合物一般在室温时是一种固体,在有机溶剂中可溶解,反映其芳香性质; 箱本体酸组的存在有助于其酸性和在各种化学反应中的潜在再活动,如酯化或恐吓; 位于三处的苯环的甲基组影响其物理和化学特性,包括其沸点和溶性; 3-M乙基苯甲酸-2-碳本体酸也可能显示生物活动,使其在药物研究中具有意义; 其独特结构允许有机合成和材料科学中的潜在应用; 与许多有机化合物一样,在处理该物质时应采取安全防范措施,因为如果浸入或吸入,可能会对健康造成危害.

结构式图片

相似化合物

2076-36-0 22367-82-4 1199-07-1

欧盟法规

ECHA物质C&L通报

上下游产品

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合成工艺路线路线简述

    3-氧代-2-苯氧基丁酸乙酯置于氢氧化钾,硫酸体系中,用 甲醇 用作溶剂,化学反应 25.0H,反应生成3-甲基苯并呋喃-2-羧酸
    参考文献:Ambient Temperature Method For The Generation And Diels-alder Trapping Of Benzofuran-2,3-Quinodimethane (2,3-Dimethylidene-2,3-Dihydrobenzofuran)
    标题:Ambient Temperature Method For The Generation And Diels-alder Trapping Of Benzofuran-2,3-Quinodimethane (2,3-Dimethylidene-2,3-Dihydrobenzofuran)
    摘要:The Ito-Saegusa Method Has Been Used To Generate Benzofuran-2,3-Quinodimethane 10 From The Corresponding Silyl Acetate 17B In Solution At-4 Degrees C. The Intermediate Reacts Efficiently With A Range Of Reactive Diels-Alder Dienophiles With Moderate To Good Levels Of Regioselection; The Structure Of The Major Diastereoisomer Has Been Determined By X-Ray Analysis.
    Doi:10.1039/p19960002827

    海关参考信息

    专利信息


    专利号:US-2021107859-A1
    优先权日:2018-04-06
    标题 :A process for the synthesis of carbon labeled organic compounds
    发明人:AUDISIO DAVIDE; CANTAT THIBAULT; DESTRO GIANLUCA
    权利人:COMMISSARIAT ENERGIE ATOMIQUE
    摘要:A process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group is described. A method of using carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; a process for manufacturing labeled pharmaceuticals and agrochemicals comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; and a process for producing tracers comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure are also described.

    专利号:WO-9427985-A1
    优先权日:1993-05-28
    标题 :Process for the preparation of substituted 3-halomethyl-benzothiophenes, benzofurans and -indoles and intermediates thereof
    发明人:PRIDGEN LENDON NORWOOD
    权利人:SMITHKLINE BEECHAM CORP; PRIDGEN LENDON NORWOOD
    摘要:This invention relates to novel intermediates and processes for preparing useful intermediates of formula (I) which are useful in the synthesis of pharmaceutically active agents.

    专利号:EP-3515880-B1
    优先权日:2017-03-17
    标题:Methods and compositions for synthesis of encoded libraries
    发明人:LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
    权利人:HITGEN INC

    专利号:US-2020149034-A1
    优先权日:2017-03-17
    标题:Methods and Compositions for Synthesis of Encoded Libraries

    专利号:EP-3549927-A1
    优先权日:2018-04-06
    标 题:A process for the synthesis of carbon labeled organic compounds

    专利号:WO-2019193068-A1
    优先权日:2018-04-06
    标 题:A process for the synthesis of carbon labeled organic compounds
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    主要参考文献

    参考标题:Brønsted Acid Catalyzed Dearomatization By Intramolecular Hydroalkoxylation/claisen Rearrangement: Diastereo‐ And Enantioselective Synthesis Of Spirolactams
    作者:Peng‐fei Chen,Bo Zhou,Peng Wu,Binju Wang,Long‐wu Ye |发布日期:2021.12.20
    摘要:A Brønsted Acid Catalyzed Intramolecular Hydroalkoxylation/claisen Rearrangement Is Disclosed That Involves An Unexpected Dearomatization Of Nonactivated Arenes And Heteroaromatic Compounds And Allows The Practical And Atom-Economic Synthesis Of Various Valuable Spirolactams. Moreover, The Asymmetric Version Of This Tandem Cyclization Is Also Achieved Via Kinetic Resolution By Chiral Phosphoric Acid

    合成参考文献


    摘要:Weibel, J.-M.; Blanc, A.; Pale, P., Science of Synthesis Knowledge Updates, (2018) 1, 99.
    摘要:Weibel, J.-M.; Blanc, A.; Pale, P., Science of Synthesis Knowledge Updates, (2018) 1, 97.
    摘要:Weibel, J.-M.; Blanc, A.; Pale, P., Science of Synthesis Knowledge Updates, (2018) 1, 29.
    摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 316.
    摘要:Zhang, M.; Su, W., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 113.
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