CAS: 21473-01-8; 2-Naphthylmagnesium Bromide

该化合物是一种在有机合成中常用的Griignard 试剂,用于引入2-nathyl 组.该试剂作为四氢呋喃的一种溶液,在碳基化合物的核循环添加物中具有高度的再活性,能够形成二级和三级酒精,以及形成碳-碳联结反应.标准浓度为0.50 M ,确保了在蒸气测量应用中的一致性能.THF作为溶剂提供了良好的溶解性和稳定性,在惰性条件下处理时尽量减少分解风险.该试剂对于建造复杂的氯化萘衍生物结构的制药和材料化学作用特别宝贵.在无水和无氧条件下适当储存对于保持其再活性至关重要.

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2-bromonaphthalene magnesium 3-(2-naphthyl)propan-1-ol 1-methyl-4-[2]naphthyl-piperidin-4-ol (E)-3-(2-naphthyl)-2-propenal 4-(2-naphthyl)-4-oxobutyric acid

合成工艺路线路线简述

    📜2-溴萘 在 Magnesium体系中,用 四氢呋喃作为反应溶剂,获得 2-Naphthalenylmagnesium Bromide
    参考文献:Synthesis And Optical Properties Of Dithienostiboles
    标题:Synthesis And Optical Properties Of Dithienostiboles
    摘要:通过β,β′-二硫代二苯并噻吩衍生物与二苯基二氯锑的反应,制备了具有与二噻吩系统融合的锑环的二噻吩锑.通过紫外吸收和发射光谱研究了它们的光学性质.还通过模型的dft计算来了解电子状态.
    Doi:10.1246/Cl.2012.1002

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    专利信息


    专利号:WO-2014011120-A1
    优先权日:2012-07-13
    标 题 :Endoperoxides, synthesis and uses thereof for the treatment of neoplastic diseases such as cancer
    发明人:TAN NGUAN SOON; CHIBA SHUNSUKE
    权利人:UNIV NANYANG TECH
    摘要:The present invention generally relates to processes and methods for the synthesis of endoperoxide compounds. More specifically, the invention relates to a method for preparing endoperoxide compounds starting from an aryl imine of formula (I) in the presence of a metallic catalyst and oxygen. The present invention also relates to endoperoxide compounds of formula (III) and their pharmaceutically acceptable salts thereof, useful for therapy. All substituents are defined herein. Also disclosed are methods of treating cancer using the compounds of formula (III).

    专利号:CN-115028641-A
    优先权日:2022-07-19
    标题:A method for cobalt-catalyzed synthesis of 5,8-difunctional substituted imidazo[1,2-a]pyrazine compounds

    专利号:CN-103755566-A
    优先权日:2014-01-17
    标 题:A new method for the synthesis of (S)-2-aryl propionate by asymmetric catalysis

    专利号:CN-108409618-B
    优先权日:2018-03-22
    标题 :A kind of method of light/nickel concerted catalysis synthesis 3- methylthio diphenylamine

    专利号:CN-108409618-A
    优先权日:2018-03-22
    标 题:A kind of photo/nickel synergistic catalytic synthesis method of 3-methylthiodiphenylamine

    专利号:EP-0558321-A1
    优先权日:1992-02-27
    标题:Antivirally active N-cycloalkyl alkanol compounds
    发明人:KURONO MASAYASU; BABA YUTAKA; OKA MITSURU; HONDA NAOKI; MATSUMOTO YUKIHARU; KAKIGAMI TAKUJI; IWATA NORIYUKI; ISHIWATA YOSHIRO; OHTUKA TAMAKI C O SANWA KAGAKU; MITANI TAKAHIKO; SAWAI KIICHI
    权利人:SANWA KAGAKU KENKYUSHO CO
    摘要:The compounds are of the general formulan n orn n where Râ‚? is -OH, amino or -SH, Râ‚‚ is H, α- or β-naphthyl or optionally substituted phenyl, R₃ is mono-, di- or tricycloalkyl of C6-16, optionally substituted, R₄₋₇ are H or alkyl, R₈₋₉ are alkyl or may form a 6-membered ring or a 5-membered ring with R₆ and R₇, Râ‚?â‚€ and Râ‚?â‚? are alkyl, and n is 0 or an integer. n Synthesis examples are given, and for the preparation of starting materials. n Pharmaceutical compositions for oral, topical or injectable administration contain the compounds or their acceptable salts. n The compounds have excellent antiviral activity as illustrated against herpes virus and may also be effective against influenza, DNA, RNA and HIV viruses.

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    合成参考文献

    参考DOI号:10.1021/jo00028a043
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