CAS: 18728-61-5; 1-(Pyridin-2-yl)Ethanol

相似化合物

27911-63-3 59042-90-9 1122-62-9

上下游产品

pyridine-2-carbaldehyde methyl magnesium iodide n-butyllithium trimethyltelluronium iodide (4-Acetylamino-phenyl)-acetic acid (R)-1-pyridin-2-yl-ethyl ester (4-Acetylamino-phenyl)-acetic acid (S)-1-pyridin-2-yl-ethyl ester 2-acetylpyridine 1-(pyridin-2-yl)ethyl benzoate

2-乙酰基吡啶置于potassium Hydroxide体系中,用 四氢呋喃 用作溶剂,化学反应 48.0H,以89%的收率获得2-(1-羟乙基)吡啶
参考文献:酮和酯的碱催化氢化硅烷化及其机理的认识
标题:酮和酯的碱催化氢化硅烷化及其机理的认识
摘要:简单的碱(ko T Bu,Koh)催化硅烷促进的酮和酯还原为醇,醛亚胺还原为胺.廉价的硅烷pmhs(聚甲基氢硅氧烷)可用作还原剂.可以容忍双键和三键以及硝基和氰基.硅烷的仔细加料允许在较低反应性基团的存在下化学选择性还原较高反应性的基团(例如,在存在酮的情况下进行醛的还原/在存在酯基的情况下进行酮的还原).机理研究表明,向硅烷中添加碱会导致硅酸盐物种,而硅酸盐物种是起作用的还原剂.在碱性条件下,氢硅氧烷(四甲基二硅氧烷,Tmds,Pmhs)转化为简单的硅烷(h 2 Sime 2,H 3 Sime),使其成为生成这些具有挑战性的硅烷的实用方法.
Doi:10.1002/chem.201302728

专利信息

专利号:US-2003162992-A1
优先权日:2001-12-14
标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides
发明人：WATANABE KYOICHI A; DU JINFA
摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.

专利号:US-6448425-B1
优先权日:2002-02-19
标题:Preparation of N-substituted aminoorganosilanes
发明人：GEDON STEVEN C; HALE MELINDA
权利人:CROMPTON CORP
摘要:A process is disclosed for the synthesis of N-cycloalkylaminoalkylsilanes, wherein the process comprises hydrogenating the corresponding N-arylaminoalkylsilanes in the presence of a catalytically effective amount of a supported or unsupported catalyst selected from the group consisting of palladium, platinum, nickel, rhenium, rhodium, ruthenium, copper chromite, and mixtures of the foregoing.

专利号:US-7465842-B2
优先权日:2004-08-26
标 题 :Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates
发明人：KUNG PEI-PEI; MARTINEZ CARLOS; TAO JUNHUA
权利人:AGOURON PHARMA
摘要:The invention relates to biocatalytic methods for preparing enantiomerically pure stereoisomers of 1-(2,6-dichloro-3-fluorophenyl)ethanol. Disclosed are methods of preparation of the desired (S)-enantiomer, which methods are based on a combination of enzymatic resolution, chemical esterification and chemical hydrolysis with inversion of 1-(2,6-dichloro-3-fluorophenyl)ethyl esters or stereoselective bio-reduction of 2,6-dichloro-3-fluoro-acetophenone with a biocatalyst such as an enzyme or a microorganism. The chiral (S)-enantiomer can be used in the synthesis of certain enantiomerically enriched, ether linked 2-aminopyridine compounds that potently inhibit auto-phosphorylation of human heptocyte growth factor receptor.

专利号:US-4546198-A
优先权日:1983-01-18
标 题 :Asymmetric synthesis of esters and acids
发明人：STOUTAMIRE DONALD W
权利人:SHELL OIL CO
摘要:Stereoisomerically-enriched esters are prepared by treating a non-symmetrical ketene with a racemic or chiral tertiary-base-substituted alkylcarbinol. Optional hydrolysis of the esters gives the corresponding optically-active carboxylic acids corresponding to the non-symmetrical ketene.

专利号:US-8377895-B2
优先权日:2008-07-10
标 题 :Cyclin-dependent protein kinases inhibitors of Scutellaria flavonoid organic amine derivatives, synthesis and use thereof
发明人：ZHANG SHIXUAN; BAO YONGMING; SUN YUMING; LI KANGJIAN; ZOU LIANG; MA JIGANG; SUN XIAODAN; SHANG HAIYAN; LI JING
权利人:ZHANG SHIXUAN; BAO YONGMING; SUN YUMING; LI KANGJIAN; ZOU LIANG; MA JIGANG; SUN XIAODAN; SHANG HAIYAN; LI JING
摘要:The present invention provides a series of cyclin-dependent protein kinases (Cdks) inhibitors, Scutellaria flavonoid organic amine derivatives, synthesis and use thereof. The preparation method is as follows: taking Baicalein (or Wogonin) from Scutellaria baicalensis as lead compound, mixting it with formaldehyde solution and organic amine compounds based on the molar ratio of 1:1-1.2:1-1.2, adding methanol of duplicate weight than baicalein and reacting at 50-70° C., filtering the sediment and washing and then drying so as to get the product with a content of not less than 97% (weight). Similar to Flavopiridol and P276-00, the activity of baicalein organic amine derivatives inhibiting Cdks has an increase of 50 times compared with that of Baicalin. It can selectively induce apoptosis of the proliferative phase cancer cells, which has scarcely any influence to the normal structure, and it belongs to anticancer drugs of cell cycle inhibitor kind. The product has a rich source of raw materials and has simple process, high purity, low cost, clear metabolic mechanism, high efficiency and low toxicity, which can be made into oral preparations or injections together with acid salts and is expected to become high efficient and low toxicity anti-cancer and AIDS drugs.

专利号:US-7459552-B2
优先权日:2003-05-28
标 题:Method for producing cyclic diamine derivative or salt thereof
发明人：SHIBUYA KIMIYUKI; OHGIYA TADAAKI; MIURA TORU
权利人:KOWA CO
摘要:The present invention is directed to a method for producing a cyclic diamine compound (3) or a salt thereof through the following scheme: n n(wherein Ar represents a phenyl group, a pyridyl group, or a pyrimidinyl group, any of which may have a substituent; X represents NH, S, or O; ring A represents a benzene ring or a pyridine ring, which may have a substituent; 1 represents an integer of 1 or 2; m represents an integer of 1 or 2; and n represents an integer of 1 to 6). The method enables synthesis of a cyclic diamine compound (3) or a salt thereof, which serves as an ACAT inhibitor, in an industrially useful manner.