CAS: 152922-73-1; Methyl 2-(1-(Mercaptomethyl)Cyclopropyl)Acetate

相似化合物

162515-68-6 162515-68-6 56406-01-0

上下游产品

1-巯甲基环丙基乙酸 1-(Sulfanylmethyl)Cyclopropaneacetic Acid 162515-68-6

二碘甲烷,置于diethylzinc体系中,用 正己烷,二氯甲烷 用作溶剂,化学反应 31.5H,以87%的收率获得1-甲巯基环丙基乙酸甲酯
参考文献:1-巯甲基环丙基乙酸的制备方法
标题:1-巯甲基环丙基乙酸的制备方法
摘要:本发明涉及一种1‑巯甲基环丙基乙酸的制备方法,属于原料药制备技术领域.本发明的技术方案是:首先以式1所述2,5‑二甲基‑2,5‑二羟基‑1,4‑二噻烷为起始原料,在碱性试剂环境中制备式2所述α,β‑不饱和羧酸酯;再以1,2‑二甲基咪唑为碱性催化剂,在紫外光照射下,制备式3所述β,γ‑不饱和羧酸酯;然后式3所述β,γ‑不饱和羧酸酯与二乙基锌,二碘甲烷经simmons‑smith反应得到式4所述环丙烷化中间体,最终式4所述环丙烷化中间体在碱性条件下水解获得目标化合物1‑巯甲基环丙基乙酸.本发明解决了现有工艺使用剧毒品,易燃易爆,废液量大,不环保的缺陷.

专利信息

专利号:WO-2012020271-A1
优先权日:2010-08-11
标题 :Process for the preparation of montelukast sodium
发明人：BODI JOZSEF; FARAGO JANOS; SZOEKE KATALIN; UJVARI VIKTOR; TEMESVARI KRISZTINA; ARANYI ANTAL; SANTA ZSUZSANNA; NAGY MELINDA MAGDOLNA
权利人:RICHTER GEDEON NYRT; BODI JOZSEF; FARAGO JANOS; SZOEKE KATALIN; UJVARI VIKTOR; TEMESVARI KRISZTINA; ARANYI ANTAL; SANTA ZSUZSANNA; NAGY MELINDA MAGDOLNA
摘要:The present invention relates to a process for the synthesis of Montelukast sodium of formula I the chemical name of which is [(R)-(E)]-1-[[[1-[3-[2-(7-chloro-2- quinolinyl)ethenyl]phenyl] -3 - [2-( 1 -hydroxy- 1 -methylethyl)phenyl]propyl] thio]methyl] - -cyclopropaneacetic acid sodium salt. The present invention further provides compounds of general formulae V, VI, VIb and VIII as new intermediates.

专利号:WO-2011121091-A1
优先权日:2010-03-31
标题:Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein
发明人：KIDEMET DAVOR; BOGDAN STEFANE; KLJAJIC ALEN; BENKIC PRIMOZ; STROPNIK TADEJ; PLAPER IGOR
权利人:KRKA D D NOVO MESTO; KIDEMET DAVOR; BOGDAN STEFANE; KLJAJIC ALEN; BENKIC PRIMOZ; STROPNIK TADEJ; PLAPER IGOR
摘要:The present invention describes the improved process for the preparation of montelukast acid (VII) and its pharmaceutically acceptable salts and esters using a novel synthesis step. The process is cost effective, environment friendly, and easily scale up to commercial level and leads to products having high chemical and optical purity. Moreover, the present invention provides a novel crystalline intermediate (IV) that is useful in this process and a method for its production. In a further aspect, the process of the present invention includes a step of removing ketone by-products be derivatization.

专利号:US-7786138-B2
优先权日:2005-11-18
标题 :Process for making montelukast and intermediates therefor
发明人：BENOVSKY PETR; THIJS LAMBERTUS; OVEREEM ARJANNE; CASTULIK JAKUB; ZHU JIE; BARTOS PETR; SKOUMAL RADOMIR
权利人:SYNTHON BV
摘要:A compound of the following formula n nwherein R′ is a straight or branched C1-C4 alkyl group is useful in processes associated with the synthesis of montelukast and its salts.

专利号:EP-2287154-A1
优先权日:2009-07-14
标题 :Efficient synthesis for the preparation of montelukast
发明人：KIDEMET DAVOR; BENKIC PRIMOZ; KLJAJIC ALEN; STEFANE BOGDAN
权利人:KRKA D D NOVO MESTO
摘要:The present invention describes the improved process for the preparation of montelukast acid and its pharmaceutically acceptable salts and esters. The process is cost effective, environment friendly, and easily scale up to commercial level.

专利号:CN-119306709-A
优先权日:2023-07-13
标题:Synthesis method of compound containing oxo-pyrido alicyclic heterocycle or alicyclic structure and novel intermediate

专利号:US-6849657-B2
优先权日:2001-07-16
标 题 :2-pyrrolidone derivatives as prostanoid agonists
发明人：ELWORTHY TODD RICHARD; ROEPEL MICHAEL GARRET; SMITH DAVID BERNARD
权利人:SYNTEX LLC
摘要:This invention relates to 8-aza prostanoid analogs which are generally EP 4 receptor agonists and are represented by Formula I: n n nwherein Q, B, X, J, Z, A and R 1 -R 6 are as defined, their synthesis and use for treatment of osteoporosis and increasing bone density.