CAS: 144693-65-2; Sodium 4-Ethynylbenzoate

相似化合物

532-32-1 10602-00-3 553-54-8

上下游产品

methyl 4-iodobenzoate 4-trimethylsilanylethynyl-benzoic acid methyl ester 4-[1-(2-fluoro-ethyl)-1H-[1,2,3]triazol-4-yl]-benzoic acid p-acetylenyl-N,N-diethylbenzamide 3)2Ru(CH=CHPh)(4-ethynylbenzoato)(CO)(P(i)Pr3)2

📜4-[(三甲基硅基)乙炔基]苯甲酸甲酯置于sodium Hydroxide体系中,用 乙醇 用作溶剂,化学反应 18.0H,以10 G的收率获得4-乙炔基苯甲酸钠
参考文献:Exploring The Udp Pocket Of Lpxc Through Amino Acid Analogs
标题:Exploring The Udp Pocket Of Lpxc Through Amino Acid Analogs
摘要:Lipopolysaccharide (Lps) Biosynthesis Is An Attractive Antibacterial Target As It Is Both Conserved And Essential For The Survival Of Key Pathogenic Bacteria. Lipid A Is The Hydrophobic Anchor For Lps And A Key Structural Component Of The Outer Membrane Of Gram-Negative Bacteria. Lipid A Biosynthesis Is Performed In Part By A Unique Zinc Dependent Metalloamidase,Lpxc (Udp-3-O-(R-3-Hydroxymyristoyl)-N-Acetylglucosamine Deacetylase),Which Catalyzes The First Non-Reversible Step In Lipid A Biosynthesis. The Udp Portion Of The Lpxc Substrate-Binding Pocket Has Been Relatively Unexplored. We Have Designed And Evaluated A Series Of Hydroxamate Based Inhibitors Which Explore The Sar Of Substitutions Directed Into The Udp Pocket With A Range Of Substituted α-Amino Acid Based Linkers. We Also Provide The First Wild Type Structure Of Pseudomonas Aeruginosa Lpxc Which Was Utilized In The Design Of Many Of These Analogs.
Doi:10.1016/j.Bmcl.2013.02.055