CAS: 13138-33-5; 3-Aminopropylphosphonic Acid

相似化合物

35622-27-6 2041-14-7 1190-09-6

上下游产品

CAS号50-00-0 甲醛 | CAS号4402-24-8 (3-氨丙基)磷酸二乙酯 | CAS号1190-09-6 3-溴丙烷膦酸 | CAS号72696-75-4 diethyl (3-(die... | CAS号107257-50-1 Diethyl [3-(N-p... | CAS号2327-69-7 4-膦酰丁酸三乙酯 | CAS号20580-37-4 3-dibutoxyphosp...

📜(3-氨丙基)磷酸二乙酯置于盐酸,Methyloxirane体系中,化学反应生成3-氨基丙烷-1-磷酸
参考文献:Borane Reduction Of Dialkoxyphosphorylcarboxamides As A New Route To Aminoalkylphosphonic Acids
标题:Borane Reduction Of Dialkoxyphosphorylcarboxamides As A New Route To Aminoalkylphosphonic Acids
摘要:一种新的简单合成氨基烷基膦酸的方法是基于用硼烷-二甲基硫化物复合物还原二烷氧基磷酰基氨基酸酰胺.
Doi:10.1055/s-1989-27149

专利信息

专利号:US-7329515-B2
优先权日:2003-04-21
标题 :Solid support for the synthesis of 3′-amino oligonucleotides
发明人：LEUCK MICHAEL; WOLTER ANDREAS
权利人:SIGMA ALDRICH CO
摘要:The present invention discloses novel methods and solid supports for the synthesis of 3′-amino oligonucleotides. The novel supports are based on an unsubstituted or ring-substituted hydroxymethylbenzoyl linker element wherein the hydroxymethyl group is esterified to a solid phase bound carboxylic acid and the carbonyl group is linked to an amino alcohol as an amide. Oligonucleotides are conveniently synthesized on the novel supports with no modifications in the standard phosphoramidite synthesis scheme. The ester function of the support is cleaved under the alkaline deprotection conditions for oligonucleotides to provide a free hydroxymethyl group that aids in the release of the 3′-amino oligonucleotide products with a free amino group through neighbor group participation. The free amino group of the oligonucleotides is available for further conjugation reactions to haptens, reporter groups, surfaces or other small molecules or biomolecules. The methods provided are particularly mild, do not require any modifications in standard protocols for the synthesis and deprotection of oligonucleotides, provide the 3′-amino oligonucleotides free of side products and do not introduce chiral centers to the oligonucleotides.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2022162188-A1
优先权日:2019-01-15
标 题:Isoprenoids and methods of making thereof
发明人：WILLIAMS GAVIN; LUND SEAN; HALL RACHAEL
权利人:UNIV NORTH CAROLINA STATE
摘要:Disclosed are methods for preparing isoprenoid subunits, as well as methods of employing these isoprenoid subunits for the synthesis of isoprenoids. Also provided are isoprenoids prepared using the methods described herein.

专利号:US-7005552-B2
优先权日:2003-11-03
标题:Single reactor synthesis of KOH-capped polyols based on DMC-synthesized intermediates
发明人：KAUSHIVA BRYAN D
权利人:BAYER MATERIALSCIENCE LLC
摘要:The present invention relates to processes for preparing ethylene oxide (EO)-capped polyols in which removal of catalyst residues or salts formed by the neutralization of the basic catalyst is not required prior to discharging the polyol from the reactor because neutralization occurs during or after the starter charge of a subsequent batch. The inventive processes allow for the preparation of DMC-catalyzed intermediates and their base-catalyzed EO caps within the same reactor. Polyols produced by the processes of the invention have a high content of primary hydroxyl groups and may be useful for producing polyurethane foams, elastomers, sealants, coatings, adhesives and the like.

专利号:JP-2005163022-A
优先权日:2003-11-03
标题 :Single reactor synthesis of KOH-capped polyols based on DMC synthesis intermediates

专利号:JP-5062951-B2
优先权日:2003-11-03
标 题:Single reactor synthesis of KOH-capped polyols based on DMC synthesis intermediates