专利号:US-2025304985-A1 优先权日:2022-04-08 标题 :Genetically Engineered Plants for Increased Production of Vindoline 发明人:LEE-PARSONS CAROLYN; COLE LAUREN F 权利人:UNIV NORTHEASTERN 摘要:Two novel transcription factors, CrDELLA1 and CrDELLA2, are described in Catharanthus roseus plants. The DELLA transcription factors have a regulatory role in the synthesis of vinblastine and vincristine, two important anti-cancer compounds that have proved difficult to obtain in sufficient quantities. The present technology provides genetically modified C. roseus plants having enhanced DELLA activity, which leads to activation of multiple enzymes in the biosynthetic pathway leading to vinblastine and vincristine. The genetic modifications can be used together with activation of plant defense mechanisms and responses to light in order to boost vinblastine and vincristine synthesis.
专利号:US-2003172398-A1 优先权日:1999-12-21 标 题 :Novel delta-12 desaturase and methods of using it for synthesis of polyunsaturated fatty acids 发明人:BROWSE JOHN A 摘要:Desaturase enzymes, and especially animal Δ 12 -desaturases, and the use of such enzymes to alter fatty acid saturation, especially fatty acid saturation in oilseeds, are disclosed. Also disclosed are nucleic acid sequences encoding animal Δ 12 -desaturase enzymes.
专利号:US-9068192-B2 优先权日:2009-01-28 标 题:Compositions and methods for conversion of aldehydes to alkanes 发明人:ZENG WEIQING; HE SHENG YANG 权利人:ZENG WEIQING; HE SHENG YANG; UNIV MICHIGAN STATE 摘要:The invention provides the discovery that SCD2 (Susceptible to Coronatine-Deficient Pst DC3118-2) protein converts aldehydes to alkanes, thereby changing the composition and/or amount of synthesized waxes. The invention additionally provides homologs, orthologs and paralogs of SCD2 protein, and nucleotide sequences encoding these proteins. Also provided are expression vectors, transgenic cells, transgenic plants, transgenic seeds, methods for altering alkane production in cells, methods for identifying the function of a nucleotide sequence in the synthesis of plant surface wax, and methods for identifying plant tissue that has an altered surface wax composition. The invention's compositions and methods are useful for altering the amount and/or composition of wax produced by cells, including plants and seeds, that have been transformed with the invention's sequences.
专利号:WO-2018122860-A1 优先权日:2017-01-02 标题:System and method for early detection for prevention of postharvest chilling injury 发明人:NOAM ALKIN 权利人:US AGRICULTURE; NOAM ALKIN 摘要:Aspects of the present invention include detection of volatile compounds related to response of vegetable or fruit, (e.g., mango), as result of stress like suboptimal temperature. Such response may lead to activation of some metabolic pathways that can induce synthesis of volatile compounds which may serve according to embodiments of the present invention as signals which indicate onset of CI and/or deterioration of fruit quality. The release of such volatiles compounds may be detected long before CI symptoms become notable. According to some embodiments of the invention, output from sensors detecting presence of volatile compounds indicating that fruits are starting to suffer from chilling stress, are received by at least one control module which operates conditioning system so as to alter storage conditions for avoiding CI and/or quality deterioration of fruits or vegetables.
专利号:US-8709811-B2 优先权日:2003-10-03 标 题:Materials and methods for synthesis of a flavor and aroma volatile in plants 发明人:KLEE HARRY J; TIEMAN DENISE 权利人:KLEE HARRY J; TIEMAN DENISE; UNIV FLORIDA 摘要:The subject invention concerns polynucleotides encoding a plant 2-phenylethanol dehydrogenase enzyme. In one embodiment, the polynucleotide encodes a tomato 2-phenylethanol dehydrogenase. The subject invention also concerns polynucleotides encoding a plant phenylalanine decarboxylase enzyme. In one embodiment, the polynucleotide encodes a tomato phenylalanine decarboxylase. The subject invention also concerns 2-phenylethanol dehydrogenase polypeptides and phenylalanine decarboxylase polypeptides encoded by polynucleotides of the present invention. The subject invention also concerns methods for providing a plant with an increased flavor and aroma volatile. Plants can be transformed with one or more polynucleotide of the present invention. The subject invention also concerns these transformed plant cells, plant tissue, and plants and transgenic progeny thereof.
专利号:WO-2019182527-A1 优先权日:2018-03-21 标 题:Methyl jasmonate derivatives as possible drug candidates for use in treatment of cancer 发明人:GUZEL MUSTAFA; OZDATLI SUKRAN; SAVLUG OZGECAN; SUCU BILGESU ONUR 权利人:T C ISTANBUL MEDIPOL UNIV 摘要:The present invention relates to the active methyl jasmonate analogues which are effective on the cancer disease and / or on the mechanisms that constitute the disease, the methods of synthesis of said analogs / derivatives and their use in the treatment of a variety of diseases, particularly for treatment of cancer and cancer-causing diseases.
参考文献:10.1186/1472-6750-11-74 摘要:Mann DG, King ZR, Liu W, Joyce BL, Percifield RJ, Hawkins JS, LaFayette PR, Artelt BJ, Burris JN, Mazarei M, Bennetzen JL, Parrott WA, Stewart CN. Switchgrass (Panicum virgatum L.) polyubiquitin gene (PvUbi1 and PvUbi2) promoters for use in plant transformation. BMC Biotechnol. 2011 Jul 11;11():74. 参考文献:10.1186/1471-2164-12-363 摘要:Délano-Frier JP, Avilés-Arnaut H, Casarrubias-Castillo K, Casique-Arroyo G, Castrillón-Arbeláez PA, Herrera-Estrella L, Massange-Sánchez J, Martínez-Gallardo NA, Parra-Cota FI, Vargas-Ortiz E, Estrada-Hernández MG. Transcriptomic analysis of grain amaranth (Amaranthus hypochondriacus) using 454 pyrosequencing: comparison with A. tuberculatus, expression profiling in stems and in response to biotic and abiotic stress. BMC Genomics. 2011 Jul 13;12():363. 参考文献:10.1007/s11033-011-1146-y 摘要:Chen YY, Wang LF, Dai LJ, Yang SG, Tian WM. Characterization of HbEREBP1, a wound-responsive transcription factor gene in laticifers of Hevea brasiliensis Muell. Arg. Mol Biol Rep. 2012 Apr;39(4):3713–9. doi: 10.1007/s11033-011-1146-y. 参考文献:10.1007/s00299-011-1121-z 摘要:Vashisth T, Johnson LK, Malladi A. An efficient RNA isolation procedure and identification of reference genes for normalization of gene expression in blueberry. Plant Cell Rep. 2011 Dec;30(12):2167–76. doi: 10.1007/s00299-011-1121-z. 参考文献:10.1007/s00299-011-1119-6 摘要:Burlini N, Iriti M, Daghetti A, Faoro F, Ruggiero A, Bernasconi S. Benzothiadiazole (BTH) activates sterol pathway and affects vitamin D3 metabolism in Solanum malacoxylon cell cultures. Plant Cell Rep. 2011 Nov;30(11):2131–41. doi: 10.1007/s00299-011-1119-6.