CAS: 99010-64-7; 4-Chloro-1-(2-Methylpropyl)-1H-Imidazo[4,5-C]Quinoline

该化合物是一种杂交循环化合物,其特征为非异丙基氮基,含有非异丁二烯和quinonline moiety,该化合物的特点是4位氯原子和1位异丁基异丁酯组,有助于其独特的化学特性.该产品一般在室内温度下是固体,在有机溶剂中可能表现出中等溶解性,视具体情况而定.氯原子的存在可影响其反应和潜在生物活动,使其对药用化学和药物开发具有兴趣.此外,该异丁乙烯组可能增强脂性,影响化合物的药用植物基因.与许多外生循环一样,它可能参与各种化学反应,包括核分裂替代物和电动嗜好芳香替代物.由于潜在的毒性或再活性,应当观测安全和处理预防措施,因为任何化学物质都可能受到注意.总体而言,4-克罗诺-1-异丁-1-H-imidazo-Hy-imidzo的化合物的进一步兴趣.

英文名称4-Chloro-1-(2-Methylpropyl)-1H-Imidazo[4,5-C]Quinoline
中文名称1-(2-甲基丙基)-4-氯-1H-咪唑并(4,5-c)喹啉
IUPAC名称4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline
其它别名1-(2-甲基丙基)-4-氯-1H-咪唑并[4,5-C]喹啉; 4-Chloro-1-Isobutyl-1H-Imidazo[4,5-C]Quinoline
CAS编号99010-64-7
MFCD编号:MFCD06658174
EINECS号:619-386-2
FDA UNII编号:NJ5E4GY4NY
分子式:C14H14ClN3
分子量:259.73
产品CID: 2028812
产品分类有机原料→分子砌块→芳杂环类化合物→咪唑类化合物

相似结构搜索
InChIKey: RRCWSLBKLVBFQD-UHFFFAOYSA-N
InChI=1S/C14H14ClN3/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数2.0

相似化合物

99010-63-6 132206-92-9 313350-31-1

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
警示词Warning(警告)
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
WGK Germany3

欧盟法规

REACH注册REACH预注册

上下游产品

1-(2-甲基丙基)-1H-咪唑并[4,5-C]喹啉 1-(2-Methylpropyl)-1H-Imidazo[4,5-C]Quinoline 99010-24-9
1-(2-甲基丙基)-1H-咪唑并[4,5-C]喹啉 5,N-氧化物 1-(2-Methylpropyl)-1H-Imidazo[4,5-C]Quinoline 5N-Oxide 99010-63-6
1-Isobutyl-1H-Imidazo[4,5-C]Quinolin-4-Ol

合成工艺路线路线简述

2-氯-N4-(2-甲基丙基)-3,4-喹啉二胺以氯仿,原甲酸三乙酯作为反应溶剂,化学反应生成 1-(2-甲基丙基)-4-氯-1H-咪唑并[4,5-C]喹啉
参考文献:3-Amino Or 3-Nitro Quinoline Compounds Which Are Intermediates In
标题:3-Amino Or 3-Nitro Quinoline Compounds Which Are Intermediates In
摘要:一种制备1-取代基,4-取代基-1H-咪唑并[4,5-C]喹啉的方法,用于制备这类化合物的中间体,以及制备这类中间体的方法.

海关参考信息

2902200000-苯
2933310010-吡啶
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:EP-0310950-B1
优先权日:1983-11-18
标题 :Quinoline intermediates for the synthesis of 1H-imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amimes
摘要:Compounds of the types (I) and (II) are disclosed, wherein each R5 is independently selected from the group consisting of alkyl of one to about four carbon atoms, alkoxy of one to about four carbon atoms and halogen, and n is an integer from 0 to 2, with the proviso that if n is 2, then said R5 substituents together contain no more than 6 carbon atoms; R6 is selected from the group consisting of hydroxyalkyl of one to about six carbon atoms and cyclohexylmethyl; and R7 is selected from the group consisting of alkyl of one to about four carbon atoms and hydrogen. These compounds may be used as intermediates for the synthesis of 1H-imidazo[4,5-c]quinoline derivatives.

专利号:US-7153967-B2
优先权日:2002-07-23
标题:Preparation of 1H-imidazo [4,5-C] quinolin-4-amines via 1H-imidazo [4,5-C] quinolin-4-phthalimide intermediates
发明人：MERLI VALERIANO; MANTOVANI SILVIA; BIANCHI STEFANO
权利人:TEVA GYOGYSZERGYAR ZARTKOERUEE
摘要:The invention provides 1H-imidazo(4,5-C)quinolin-4-phthalimide intermediates useful in the synthesis of 1H-imidazo(4,5-C)quinoline-4-amines, particularly Imiquimod. The invention further provides a method for making the intermediates and a method for making 1H-imidazo(4,5-C)quinoline-4-amines via the intermediates.

专利号:RU-2083563-C1
优先权日:1989-10-26
标题:Method of synthesis of derivatives of 2-chloro-nitroquinolineamines, method of synthesis of 2-chloro-3,4-diaminoquinolines, method of synthesis of derivatives of 4-chloro-1h-imidazo-[4,5-c]-quinolines, method of synthesis of derivative of 1h-imidazo-[4,5-c]-quinolines, 2-chloro-3-nitroaminoquinoline, 2-chloro-3,4-diaminoquinoline

专利号:US-7335772-B2
优先权日:2002-07-26
标题:1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinolin-4-carboxamide intermediates
发明人：MERLI VALERIANO; MANTOVANI SILVIA; BIANCHI STEFANO
权利人:TEVA GYOGYSZERGYAR ZARTKOERUEE
摘要:The invention relates to a process for the synthesis of 1H-imidazo[4,5-c]quinoline 4-cyano and 1H-imidazo[4,5-c]quinoline 4-carboxamide intermediates useful in preparing 1 H-imidazo[4,5-C]quinoline 4-amines, a process for preparing 1H-imidazo[4,5-C]quinoline 4-amines using such intermediates; and, to the 1H-imidazo[4,5-c]quinoline 4-cyano and 1H-imidazo[4,5-c]quinoline 4-carboxamide intermediates. More particularly, the invention relates to a process for the preparation of 1-isobutyl-1H-imidazo[4,5-C]quinoline 4-amine (Imiquimod) using two intermediates, 1-isobutyl-1H-imidazo[4,5-c]quinoline 4-cyano and 1-isobutyl-1H-imidazo[4,5-c]quinoline 4-carboxamide, and to the said intermediates.

专利号:DE-3486043-T2
优先权日:1983-11-18
标题:INTERMEDIATE CHINOLINE PRODUCTS FOR THE SYNTHESIS OF 1H-IMIDAZO (4,5-C) QUINOLINES AND 1H-IMIDAZO (4,5-C) QUINOLIN-4-AMINES.

专利号:EP-0310950-A1
优先权日:1983-11-18
标题:Quinoline intermediates for the synthesis of 1H-imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amimes

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