CAS: 932372-99-1; 2-Bromo-5-Iodophenol

该化合物是一种有机化合物,其特征是酚环上同时存在溴和碘替代物.该化合物的特征是苯环第二位置的溴原子和苯环第五位置的碘原子,这影响其化学反应和物理特性.作为苯环化合物,该化合物具有典型特征,例如,由于氢氧(-OH)组而形成氢结的能力,这促使其在极地溶剂中溶解.卤素(溴和碘)的存在可以增强它的再活性,使其在各种化学合成应用中有用,包括作为有机合成的中间体.此外,该化合物可能展示生物活动,可以在药用化学中加以探索.其分子结构和亚体特征可以影响其熔点,沸点和光谱特性,使其在学术和工业研究中都受到关注.在处理该化合物时,应当采取安全防范措施,因为与卤化有机化合物有关的潜在危害.

结构式图片

上下游产品

CAS号755027-18-0 2-溴-5-碘苯甲醚 | CAS号43192-34-3 4-溴-3-甲氧基苯甲醛 | CAS号755027-18-0 2-溴-5-碘苯甲醚

合成工艺路线路线简述

  • 755027-18-0 = 932372-99-1
    反应条件:1.1 Reagents: Boron Tribromide Solvents: Dichloromethane; 30 Min,-10 °C; 1 H,0 °C; 16 H,Rt1.2 Reagents: Sodium Carbonate Solvents: Water
    标题:Preparation Of Heteroaryl Compounds For Treating Huntington'S Disease
    参考文献:World Intellectual Property Organization]

    755027-18-0 = 932372-99-1
    反应条件:1.1 Reagents: Boron Tribromide Solvents: Dichloromethane; 0 °C; 3 H,0 °C1.2 Reagents: Water; 0 °C
    标题:3-Sulfonyloxyaryl(Mesityl)Iodonium Triflates As 1,2-Benzdiyne Precursors With Activation Via Ortho-Deprotonative Elimination Strategy
    作者:Yuan,Haoyin; Yin,Wenhao; Hu,Jili; Li,Yang
    参考文献:Nature Communications 日期:2023 卷标:14(1)]

    755027-18-0 = 932372-99-1
    反应条件:1.1 Reagents: Boron Tribromide Solvents: Dichloromethane; -78 °C; 1 H,-78 °C; -78 °C -> Rt; Overnight,Rt1.2 Reagents: Water; Rt
    标题:Nanopatterning By Molecular Polygons
    作者:Jester,Stefan-S.; Sigmund,Eva; Hoger,Sigurd
    参考文献:Journal Of The American Chemical Society 日期:2011 卷标:133(29) 页码:11062-11065]

    111721-74-5 = 932372-99-1
    反应条件:1.1 Reagents: Sodium Nitrite,Sulfuric Acid Solvents: Water; 5 - 10 °C1.2 Reagents: Sulfuric Acid,Copper Sulfate; 80 °C
    标题:Industrial Preparation Method Of 2-Bromo-5-Iodophenol From O-Nitroaniline
    参考文献:China]

    = 932372-99-1 [标题:Reaction Conditions
    标题:Preparation Of Sulfonamide Derivatives As Pgd2 Receptor Antagonists
    参考文献:World Intellectual Property Organization]

    755027-18-0 = 932372-99-1
    反应条件:1.1 Reagents: Boron Tribromide Solvents: Dichloromethane; -10 °C; 17 H,-10 °C -> Rt1.2 Reagents: Methanol; Rt; 10 Min,Rt
    标题:Preparation Of Heterocyclic Nitrogen Compounds As Nlrp3 Inhibitors And Antiinflammatory Agents
    参考文献:China]

    755027-18-0 = 932372-99-1
    反应条件:1.1 Reagents: Boron Tribromide Solvents: Dichloromethane; 30 Min,< 0 °C; 1 H,0 °C; 16 H,Rt
    标题:Preparation Of Heterocyclic And Heteroaryl Compounds For Treating Huntington'S Disease
    参考文献:World Intellectual Property Organization]

    755027-18-0 = 932372-99-1
    反应条件:1.1 Reagents: Boron Tribromide Solvents: Dichloromethane; 30 Min,Cooled; 1 H,Cooled; 3 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Cooled; 1 H,Rt
    标题:Method For Producing N-Phenyl-N'-Phenylsulfonylpiperazine Derivative
    参考文献:World Intellectual Property Organization]

    755027-18-0 = 932372-99-1
    反应条件:1.1 Reagents: Boron Tribromide Solvents: Dichloromethane; 0 °C; 16 H,0 °C -> Rt
    标题:Preparation Of Trifluoromethyl Alcohols As Modulators Of Rorγt
    参考文献:United States]

    = 932372-99-1 [标题:Reaction Conditions
    标题:Preparation Of Heterocyclic Substituted 1,3,4-Thiadiazole And Pyridazine Compounds And Methods Of Using The Same
    参考文献:World Intellectual Property Organization]

    = 932372-99-1 [标题:Reaction Conditions
    标题:Preparation Of Heteroaryl Compounds For Treating Huntington'S Disease
    参考文献:World Intellectual Property Organization
📜4-碘-2-硝基苯胺置于硫酸,铁粉,氯化铵,Sodium Nitrite体系中,用 水 作为反应溶剂,化学反应生成 2-溴-5-碘苯酚
参考文献:一种2-溴-5-碘苯酚的制备方法
标题:一种2-溴-5-碘苯酚的制备方法
摘要:本发明公开了一种2‑溴‑5‑碘苯酚的工业化制备方法.该2‑溴‑5‑碘苯酚的工业化制备方法,以邻硝基苯胺为初始原料,经上碘,重氮化上溴,还原以及重氮化上酚羟基四步反应合成2‑溴‑5‑碘苯酚.本过程得到的2‑溴‑5‑碘苯酚为蓝色固体,纯度97.5%,每步原料转化率分别达到100%,整个过程的总收率达到17%.

海关参考信息

专利信息


专利号:US-2010197692-A1
优先权日:2007-07-20
标 题 :Bicyclic heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人:RAMTOHUL YEEMAN K; LI CHUN SING; LECLERC JEAN-PHILIPPE
权利人:MERCK FROSST CANADA LTD
摘要:Bicyclic heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis.

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