CAS: 9031-37-2; Mpb Ceruloplasmin,From Human Serum
该化合物是主要在肝脏中合成的多功能甘蓝蛋白,在铜运输和铁新陈代谢中发挥着关键作用; 蛋白质是等离子体中主要含有铜的蛋白质,它展示了铁氧化酶的活动,促进Fe2+氧化到Fe3+,以纳入转移剂; 该蛋白质对于保持系统铁的全态保持和防止氧化性压力至关重要; 生物化学和临床研究中广泛使用重组或净化的人类蛋白质,特别是在与威尔逊病,蛋白性贫血和...
- 英文名称Mpb Ceruloplasmin,From Human Serum
- 中文名称血浆铜蓝蛋白来自人血清
- 其它别名CERULOPLASMIN; CERULOPLASMIN BOVINE; CERULOPLASMIN, HUMAN; CERULOPLASMIN, HUMAN PLASMA; CERULOPLASMIN, FROM HUMAN SERUM; MPB Ceruloplasmin,from Human Serum
- CAS编号9031-37-2
- MFCD编号:MFCD00130766
- EINECS号:232-868-3
- 分子式:C29H30FN2NaO4分子量:0.0
- 产品CID: 1935542
- 产品分类氧化还原酶 → 氧化金属离子
物理性质
- 沸点1539.6±75.0 °C at 760 mmHg
- 闪点884.9±37.1 °C
- LogP:8.77
- 蒸汽压0.0±0.6 mmHg at 25°C
- 溶解性Water: 1mg/mL
- 敏感性Analysis Note Protein determined by biuret Bi°Chem/physiol Actions Ceruloplasmin (Cp), the principal carrier of copper in plasma, is thought to be involved in oxidative modification of lipoproteins and participate in the acute phase reaction to stress. Cp is an effective antioxidant for a variety of radicals and has a potent peroxidase activity to decompose hydrogen peroxide in the presence of reduced glutathione. It inhibits the peroxidase activity of myeloperoxidase in a concentration-dependent manner and shows selective binding to myeloperoxidase in vitro. This suggests that ceruloplasmin may participate in the clearance and inactivation of myeloperoxidase in vivo. At physiological (micromolar) concentrations it was found to inhibit relaxation of rabbit aorta induced by endothelium-dependent agonists like acetylcholine or ADP. However, it was found ineffective toward vasodilation due to direct stimulation of smooth muscle cells by nitroglycerin. Unit Definition One unit will cause a ΔA550 of 0.01 per min using N,N-dimethyl-p-phenylenediamine as substrate at pH 5.5 and 37 °C, in a 7 mL reaction volume. Physical form Pale blue powder containing sodium chloride and sodium acetate
- 外观形态类白色至淡黄色盐水溶液
- 储存条件-20°C
合成工艺路线路线简述
海关参考信息
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