专利号:US-2022064145-A1 优先权日:2020-08-28 标 题 :Synthesis of poziotinib derivative 发明人:BANG KEUK CHAN; MOON YOUNG HO; CHANG YOUNG KIL 权利人:HANMI SCIENCE CO LTD 摘要:A method for the synthesis of a compound of Formula II is provided. Also disclosed is the salt form of the compound. The method includes the introduction of a piperidinyl moiety in a polar aprotic solvent system, followed by the removal of the protecting group and the acrylation step.
专利号:US-2021221792-A1 优先权日:2020-01-16 标题:Convergent synthesis of poziotinib derivative 发明人:CHAN BANG KEUK; HYUK JUNG JAE; HO MOON YOUNG 权利人:HANMI PHARM IND CO LTD 摘要:A method of for the synthesis of a compound of Formula I is disclosed herein. The method includes reacting a compound of formula (II) with a compound of formula (III) in an inert polar aprotic solvent system in the presence of a base.
专利号:WO-2022043923-A1 优先权日:2020-08-28 标题 :Synthesis of poziotinib derivative