专利号:US-5597931-A 优先权日:1992-03-30 标 题:Total synthesis of taxol and analogues thereof 发明人:DANISHEFSKY SAMUEL J; MASTERS JOHN; YOUNG WENDY; LINK J THOMAS; ISAACS RICHARD; SNYDER LAWRENCE B 权利人:SLOAN KETTERING INST CANCER 摘要:The present invention provides three basic routes for the total synthesis of taxol having the structure: ##STR1## The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as well as analogues of taxol and nortaxol.
专利号:US-5488116-A 优先权日:1992-03-30 标 题:Total synthesis of taxol and analogues thereof 发明人:DANISHEFSKY SAMUEL J; BORNMANN WILLIAM G; QUENEAU YVES; MAGEE THOMAS V; KROL WALTER J; MASTERS JOHN J; JUNG DAVID K 权利人:SLOAN KETTERING INST CANCER 摘要:The present invention provides three basic routes for the total synthesis of taxol having the structure: ##STR1## The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as well as analogues of taxol and nortaxol.
专利号:US-5527924-A 优先权日:1992-03-30 标题 :Total synthesis of taxol 发明人:DANISHEFSKY SAMUEL J; BORNMANN WILLIAM G; QUENEAU YVES; MAGEE THOMAS V; KROL WALTER J 权利人:SLOAN KETTERING INST CANCER 摘要:The present invention provides two basic routes for the total synthesis of taxol having the structure: The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as well as analogs to taxol. Both the intermediates and analogs to taxol may prove to be valuable anticancer agents.
专利号:US-7652137-B2 优先权日:2003-03-06 标 题:Synthesis of 5 substituted 7-azaindoles and 7-azaindolines 发明人:GRACZYK PIOTR PAWEL; KHAN AFZAL; BHATIA GURPREET SINGH 权利人:EISAI R&D MAN CO LTD 摘要:The present invention provides a novel substituted azaindoline intermediate of formula (I) and a method for its synthesis. The novel substitued azaindoline intermediate (I) is provided for use in the manufacture of 5-substituted 7-azaindolines and 5-substituted 7-azaindoles.
专利号:US-2018361327-A1 优先权日:2016-02-26 标题 :Gas separation membrane, gas separation module, gas separator, gas separation method, composition for forming gas separation layer, method of producing gas separation membrane, polyimide compound, and diamine monomer 发明人:KODAMA KEISUKE; SAWADA MAKOTO; WADA KENJI 权利人:FUJIFILM CORP 摘要:A gas separation membrane including a gas separation layer contains a crosslinked polyimide compound. In the gas separation membrane, and a gas separation module, a gas separator, and a gas separation method obtained by using the gas separation membrane, the crosslinked polyimide compound has a specific structural portion. A composition for forming a gas separation layer suitable for forming a gas separation layer of the gas separation membrane; a method of producing a gas separation membrane obtained by using this composition; a polyimide compound suitable as a raw material of a gas separation layer of the gas separation membrane; and a diamine monomer suitable for synthesis of this polyimide compound are provided.
专利号:US-7897762-B2 优先权日:2006-09-14 标 题:Kinase inhibitors useful for the treatment of proliferative diseases 发明人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C 权利人:DECIPHERA PHARMACEUTICALS LLC 摘要:The present invention relates to novel kinase inhibitors and modulator compounds useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.
[参考文献]: Karsten Menzel, Et Al. Room-Temperature Stille Cross-Couplings Of Alkenyltin Reagents And Functionalized Alkyl Bromides That Possess Beta Hydrogens. J Am Chem Soc. 2003 Apr 2;125(13):3718-9. [参考文献]: Masahiro Yoshida, Et Al. Palladium-Catalyzed Ring Expansion Reaction Of (Z)-1-(1,3-Butadienyl)Cyclobutanols With Aryl Iodides. Stereospecific Synthesis Of (Z)-2-(3-Aryl-1-Propenyl)Cyclopentanones. Org Lett. 2004 Jun 10;6(12):1979-82. [参考文献]: R Skoda-Fldes, Et Al. Palladium-Catalyzed Homogeneous Coupling Reactions Of Steroids With Organostannanes. Steroids. 1995 Dec;60(12):812-6.
合成参考文献
摘要:Koo, S., Science of Synthesis, (2010) 45, 1351. 摘要:Negishi, E.; Wang, G., Science of Synthesis, (2009) 46, 266. 摘要:Negishi, E.; Wang, G., Science of Synthesis, (2009) 46, 290. 摘要:Roy, K.-M., Science of Synthesis, (2010) 47, 1142. 摘要:Snaith, J. S., Science of Synthesis Knowledge Updates, (2011) 2, 235.