CAS: 6812-87-9; 1-Hydroxy-2-Isopropyl-4B,8,8-Trimethyl-4B,5,6,7,8,8A,9,10-Octahydrophenanthrene-3,4-Dione
该化合物是一种自然形成的化学化合物,被归类为类固醇,主要来自各种植物物种,特别是Lamiaceae家族的植物,如玫瑰.该化合物以其独特的芳香特性著称,有助于提取该化合物的植物的芳香.Royleanone展示了潜在的生物活动,包括抗微生物和抗氧化特性,使其对制药和化妆品的应用都感兴趣.其分子结构是碳和氢原子的复杂安排,典型的类固醇类,通常具有多种生物效应.此外,Roylean的稳定性和溶性特征可因所使用的溶剂而异,影响其在配方中的应用.研究继续探索其在各种行业的潜在健康惠益和用途,强调天然化合物在开发新的治疗剂中的重要性.
- 英文名称1-Hydroxy-2-Isopropyl-4B,8,8-Trimethyl-4B,5,6,7,8,8A,9,10-Octahydrophenanthrene-3,4-Dione
- 中文名称罗列酮
- IUPAC名称1-hydroxy-2-isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-3,4-dione
- 其它别名1-Hydroxy-4B,8,8-Trimethyl-2-Propan-2-Yl-5,6,7,8A,9,10-Hexahydrophenan Threne-3,4-Dione; (4Bs)-2-Isopropyl-3-Hydroxy-4Bα,8,8-Trimethyl-4B,5,6,7,8,8Aβ,9,10-Octahydrophenanthrene-1,4-Dione; (4Bs,8As)-4B,5,6,7,8,8A,9,10-Octahydro-3-Hydroxy-4B,8,8-Trimethyl-2-Isopropyl-1,4-Phenanthrenedione; 12-Hydroxyabieta-8,12-Diene-11,14-Dione; 12-Hydroxy-13-Isopropylpodocarpa-8,12-Diene-11,14-Dione; 1,4-Phenanthrenedione, 4B,5,6,7,8,8A,9,10-Octahydro-3-Hydroxy-4B,8,8-Trimethyl-2-(1-Methylethyl)-, (4Bs,8As)-; (4Bs,8As)-3-Hydroxy-2-Isopropyl-4B,8,8-Trimethyl-4B,5,6,7,8,8A,9,10-Octahydrophenanthrene-1,4-Dione
- CAS编号6812-87-9
- MFCD编号:MFCD26406092
- FDA UNII编号:901618Q8AX
- 分子式:C20H28O3分子量:316.44
- 产品CID: 1668930
- 产品分类天然产物 → 醌类天然产物
物理性质
- 熔点181.5-183.0 °C(溶剂: acetic acid (64-19-7))
- 沸点426.4±45.0 °C(预测)
- 闪点221.2 °C
- 密度1.12±0.1 g/cm3(预测)
- pKa:4.50±1.00(预测)
- PSA:54.37
- LogP:4.5293
- 折射率1.548
- 蒸汽压9.14E-09 mmHg at 25 °C
- 外观形态固体-粉末
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用该化合物是一种二元细胞,通过诱导米托尔/PI3K/AKT信号路径的米托氏体介介质疏松症,细胞循环阻断,抑制细胞迁移和下调,在LNCAP人类前列腺癌细胞中表现出强大的抗癌效应.
MSDS等安全信息
上下游产品
7-acetylhorminone d-11,12-dimethoxyabieta-8,11,13-triene 7α-acetoxyroyleanone (+)-winterin (+)-confertifoline合成工艺路线路线简述
📜(4Br,8Ar)-1,3,4-Trimethoxy-4B,8,8-Trimethyl-2-Propan-2-Yl-5,6,7,8A,9,10-Hexahydrophenanthren-9-Ol 在 咪唑,偶氮二异丁腈,氧气,三正丁基氢锡,三溴化硼,Sodium Hydride体系中,获得 Royleanone
参考文献:A Synthesis Of The Abietane Diterpenoid Quinone (+/-)-Royleanone Via Maleoylcobalt Technology.
标题:A Synthesis Of The Abietane Diterpenoid Quinone (+/-)-Royleanone Via Maleoylcobalt Technology.
摘要:
Doi:10.1016/S0040-4039(00)97454-9
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2901241000-1,3-丁二烯
2905121000-正丙醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Li CJ, Xia F, Wu R, Tan HS, Xu HX, Xu G, Qin HB. Synthesis and Cytotoxicities of Royleanone Derivatives. Nat Prod Bioprospect. 2018 Dec;8(6):453-456. doi: 10.1007/s13659-018-0173-y. Epub 2018 Jun 16.
2: Wu X, He Y, Zhang G, Wu J, Hou Y, Gu Y, Chen H. Royleanone diterpenoid exhibits potent anticancer effects in LNCaP human prostate carcinoma cells by inducing mitochondrial mediated apoptosis, cell cycle arrest, suppression of cell migration and downregulation of mTOR/PI3K/AKT signalling pathway. J BUON. 2018 Jul-Aug;23(4):1055-1060. doi: 10.1002/ptr.4961. Epub 2013 Mar 11. doi: 10.1107/S2056989017017935. eCollection 2018 Jan 1.
5: Xu S, Ma X, Ke R, Deng S, Yang X, Song P. Crystal structure of 7β-hy-droxy-royleanone isolated from Taxodium ascendens (B.). Acta Crystallogr E Crystallogr Commun. 2017 Sep 5;73(Pt 10):1414-1416. doi: 10.1107/S2056989017011987. eCollection 2017 Oct 1.
合成参考文献
参考文献:10.5281/zenodo.5794106
摘要:The LOTUS Initiative for Open Natural Products Research: frozen dataset union wikidata (with metadata) | DOI:10.5281/zenodo.5794106
📝 需求与反馈
尽可能描述清楚需求与问题信息
