CAS: 65604-89-9; Tris[2-(Methylamino)Ethyl]Amine

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105-84-0 61877-80-3 7382-58-3

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CAS号4097-89-6 三(2-氨基乙基)胺 | CAS号541-41-3 氯甲酸乙酯 | CAS号147631-18-3 1-methyl-N,N',N... | CAS号102-71-6 三乙醇胺 | CAS号50-00-0 甲醛 | CAS号120666-13-9 2,8,9-三甲基-2,5,8... | CAS号31701-36-7 5-methyl-1,4,6,...

📜Tris(N-Ethoxycarbonyl-2-Aminoethyl)Amine置于lithium Aluminium Tetrahydride,Potassium Hydroxide体系中,用 四氢呋喃 作为反应溶剂,以19%的收率获得产物三[2-(甲基氨基)乙基]胺
参考文献:在一系列新型的合成六齿铁(iii)螯合剂中,1-羟基-2(1H)-吡啶酮配位基团与三(2-氨基乙基)胺核之间的键合对抗菌活性的影响.
标题:在一系列新型的合成六齿铁(iii)螯合剂中,1-羟基-2(1H)-吡啶酮配位基团与三(2-氨基乙基)胺核之间的键合对抗菌活性的影响.
摘要:病原体对抗菌素的耐药性是当前主要的医疗保健问题.在一系列相关研究中,我们研究了基于羟基吡啶酮配体作为新型抑菌剂的合成铁螯合剂.在本文中,我们描述了基于1-羟基-2(1H)-吡啶酮部分的几种有用结构单元的合成,包括新型甲酰基衍生物,它们与三(2-氨基乙基)胺核结合以获得一系列新的高亲和力六齿fe(iii)螯合剂.该系列研究的设计原理是核心和金属配体之间的连接基团的大小和柔性.进行代表性配位基团的pka和稳定性常数(fe3 +和cu2 +)的测量,以帮助合理化螯合剂的生物活性.新型螯合剂在一组代表性微生物上进行了测试,其中一些微生物有效地抑制了微生物的生长.我们证明羟基吡啶酮和三(2-氨基乙基)胺核之间的连接基的性质和位置对微生物的生长抑制有相当大的影响,酰胺或胺键都可以提供有效的螯合剂.
DOI:10.1016/j.Bioorg.2019.103465

专利信息

专利号:US-2025049714-A1
优先权日:2021-12-09
标题 :Synthesis of ester, carbonate, and carbamate-derived novel biodegradable ionizable lipids from methyl ricinoleate or methyl 12-hydroxystearate and its applications
发明人：ANDERSON DANIEL GRIFFITH; RHYM LUKE HYUNSIK; LI BOWEN; GORDON AKIVA; RAJITH SINGH MANAN; WITTEN JACOB
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, and isotopically labeled derivatives thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of polynucleotides, such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, liver disease, spleen disease, lung disease, painful condition, psychiatric disorder, musculoskeletal disease, a metabolic disorder, inflammatory disease, or autoimmune disease).

专利号:US-2013102730-A1
优先权日:2010-04-02
标 题:Polyamine-containing polymers and methods of synthesis and use
发明人：JOST ROBERT W; ULUDAG HASAN; BOLUK MEHMET YAMAN
权利人:JOST ROBERT W; ULUDAG HASAN; BOLUK MEHMET YAMAN; ALBERTA INNOVATES TECHNOLOGY FUTURES
摘要:The present invention relates to polyamine-containing polymers and methods of their synthesis and use. The polymer may be hydroxyethylcellulose, dextran, poly(vinyl alcohol) or poly(methyl acrylate).

专利号:US-12037641-B2
优先权日:2015-11-20
标题:Modified nucleotide reagents
发明人：SHEN GENE; YUE STEPHEN; SEBO LUBOMIR; BROGLEY LOUIS
权利人:PACIFIC BIOSCIENCES CALIFORNIA INC
摘要:Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided. The analogs are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The analogs are detectable with high sensitivity at desirable wavelengths. They contain structural components that modulate the interactions of the analogs with DNA polymerase, thus decreasing photodamage and improving the kinetic and other properties of the analogs in sequencing reactions. Also provided are nucleotide and dye-labeled compounds of the subject analogs, as well as intermediates useful in the preparation of the compounds and analogs. Compositions comprising the compounds, methods of synthesis of the intermediates, compounds, and analogs, and mutant DNA polymerases are also provided.

专利号:US-8742045-B2
优先权日:2009-06-03
标题:Polymerization initiator for living radical polymerization
发明人：GOTO ATSUSHI; KIM JEONG SIK; TSUJII YOSHINOBU; FUKUDA TAKESHI
权利人:GOTO ATSUSHI; KIM JEONG SIK; TSUJII YOSHINOBU; FUKUDA TAKESHI; UNIV KYOTO
摘要:Provided is a method of living radical polymerization which does not necessitate complicated and intricate synthesis of a dormant species and which is highly efficient. A halogenated derivative compound is used as a dormant species for initiating living radical polymerization. The derivative compound is obtained by halogenating an alcohol compound having a non-conjugated structure or an amine compound having a non-conjugated structure with a halogenating agent capable of halogenating an alcohol or amine. A radical produced by elimination of halogen from the halogenated derivative compound is allowed to react with the unsaturated bond of the monomer. Thus, the monomer, which has a radical-reactive unsaturated bond, is polymerized by living radical polymerization. Preferably, the halogenating agent is a compound (NIS or the like) which also has a function as a catalyst.

专利号:WO-2023107648-A2
优先权日:2021-12-09
标 题:Synthesis of ester, carbonate, and carbamate-derived novel biodegradable ionizable lipids from methyl ricinoleate or methyl 12-hydroxystearate and its applications

专利号:US-9957291-B2
优先权日:2013-08-05
标题 :Protected fluorescent reagent compounds
发明人：SEBO LUBOMIR; HANES JEREMIAH; SHEN GENE; BROGLEY LOUIS; YUE STEPHEN; ZHENG FRANK; LAPIN YURI; LYLE JOHN; OSUNA HONEY; FEDOROV ANDREI
权利人:PACIFIC BIOSCIENCES CALIFORNIA INC
摘要:Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The compounds contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements.