CAS: 628-89-7; 2-(2-Chloroethoxy)Ethanol

上下游产品

CAS号75-21-8 环氧乙烷 | CAS号107-07-3 2-氯乙醇 | CAS号111-46-6 二乙二醇 | CAS号14258-40-3 2-氯乙氧基乙基醋酸酯 | CAS号123-91-1 1,4-二氧六环 | CAS号2568-30-1 氯乙醛缩乙二醇 | CAS号107-21-1 乙二醇 | CAS号111-44-4 二氯乙基醚 | CAS号7664-93-9 硫酸 | CAS号104568-29-8 2-[2-(3,3,4,4,5... | CAS号104568-24-3 2-[2-(3,3,4,4,5... | CAS号3733-63-9 去氯羟嗪 | CAS号14258-40-3 2-氯乙氧基乙基醋酸酯 | CAS号929-06-6 二甘醇胺 | CAS号299167-98-9 2,7-bis[2-(2-hy... | CAS号2192-20-3 盐酸羟嗪 | CAS号127441-50-3 4-[2-(2-hydroxy... | CAS号139115-90-5 2-(2-叠氮乙氧基)乙醇 | CAS号111-44-4 二氯乙基醚

2-(2-Chloroethoxy)Ethyl Nitrite置于potassium Chloride体系中,用 1,4-二氧六环 作为反应溶剂,化学反应生成 2-氯乙氧基乙醇
参考文献:Buckell,Felicity; Hartry,Jeffrey D.; Rajalingam,Umarani,Journal Of The Chemical Society. Perkin Transactions Ii,1994,# 3,P. 401-404
标题:Buckell,Felicity; Hartry,Jeffrey D.; Rajalingam,Umarani,Journal Of The Chemical Society. Perkin Transactions Ii,1994,# 3,P. 401-404

专利信息

专利号:US-7071331-B2
优先权日:2003-02-22
标 题 :Synthesis of quetiapine and pharmaceutically acceptable salts thereof
发明人：DILLER DOV; DOLITZKY BEN-ZION
权利人:TEVA PHARMA
摘要:Provided is a novel synthesis of quetiapine employing phase transfer catalyst.

专利号:EP-1660469-B1
优先权日:2003-07-18
标题 :Process for the preparation of 11-(1-piperazinyl)dibenzo 'b, f! '1 ,4!-thiazepine, an intermediate in the synthesis of the antipsychotic drug quetiapine
发明人：KACZMAREK LUKASZ; BADOWSKA-ROSLONEK KATARZYNA; STOLARCZYK ELZBIETA; SZELEJEWSKI WIESLAW
权利人:HELM AG; INST FARMACEUTYCZNY
摘要:A process for the preparation of 11-(1-piperazinyl)dibenzo-[b, f ] [ 1, 4 ] thiazepine comprising reacting phenyl 2­(phenylthio) phenylcarbamate with piperazine and cyclizing the obtained N-[ (2 -phenylthio) phenyl ] -1 -piperazinylcarboxamide in a presence of cyclizing agent. 11-(1-piperazinyl)-dibenzo [b, f] [1, 4]thiazepine is itself, an intermediate in the synthesis of antipsychotic drug Quetiapine.

专利号:US-8506927-B2
优先权日:2011-01-05
标 题 :Pegylated fluorobenzamide analogues, their synthesis and use in diagnostic imaging
发明人：MACH ROBERT H; TU ZHUDE
权利人:MACH ROBERT H; TU ZHUDE; UNIV WASHINGTON
摘要:Pegylated fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labeled with a positron-emitting radioisotope such as 18 F, can be used as radiotracers for medical imaging such as imaging of tumors by positron emission tomography (PET). In addition, these compounds, when labeled with 123 I, can be used as radiotracers for imaging of tumors by single photon emission computed tomography (SPECT). Methods for synthesis of these compounds are also disclosed.

专利号:US-5446186-A
优先权日:1993-11-09
标 题:Structure and synthesis of nitrophenyl-EGTA, a caged calcium, intermediates thereof and a method of producing a high photochemical yield of liberated calcium
发明人：ELLIS-DAVIES GRAHAM C R; KAPLAN JACK H
摘要:The synthesis and compound of a new caged calcium which is an ortho-nitrophenyl derivative of EGTA and various intermediates. It is synthesized in ten steps and 24% overall yield. The photosensitive chelator, nitrophenyl-EGTA, has a K d for Ca 2+ of 80 nM and for Mg 2+ of 8.8 mM. Upon exposure to ultra-violet light (in the region of 350 nm), the chelator is cleaved, yielding iminodiacetic acid photoproducts with known low Ca-affinity (K d =1 mM). The quantum yield of photolysis of nitrophenyl-EGTA in the presence of Ca a+ is 0.23 and in the absence of Ca 2+ is 0.20. In experiments with chemically skinned skeletal muscle fibers, a fully relaxed fiber equilibrated with nitrophenyl-EGTA:Ca 2+ complex, in the presence of physiological [Mg 2+ ] (i.e. 1.0 mM), produced maximal contraction after a single flash from a frequency doubled ruby laser (347 nm). Half-maximal tension was achieved in 18 ms at 15° C. Nitrophenyl-EGTA provides a new tool for the investigation of the mechanism of Ca 2+ -dependent physiological processes, since under conditions of normal intracellular Ca 2+ and Mg 2+ ions, only Ca 2+ ions are bound by the photolabile chelator and on illumination are released rapidly and in high photochemical yield.

专利号:US-7897638-B2
优先权日:2005-04-12
标题:Synthesis of nitrodibenzylfuran chromophore for photodeprotection of organic molecules
发明人：ELLIS-DAVIES GRAHAM; MOMOTAKE ATSUYA
权利人:PHILADELPHIA HEALTH & EDUCATIO
摘要:Inventors have developed a chromophore (nitrodibenzylfuranyl, or NBDF) for ultra efficient uncaging of a caged substrate (e.g., an organic molecule such as, for example, an amino acid, a biological molecules, such as, for example, second messengers inside cells). Photolysis of a NBDF derivative of EGTA (i.e. caged calcium) is about 50 times more efficient than others calcium cages (the quantum yield of photolysis is 0.6 and the extinction coefficient is 18,400. NDBF-EGTA has a 2-photon cross section of about 0.3-0.6 GM).

专利号:US-12337036-B2
优先权日:2018-01-01
标题:Compounds and methods for trans-membrane delivery of molecules
发明人：ZIV ILAN; GRIMBERG HAGIT; DUBROVSKY JOSEPH
权利人:APOSENSE LTD
摘要:The Invention provides a novel delivery system for delivery of drugs across biological membranes. It provides novel chemical conjugates that comprise said delivery system, methods for synthesis of said compounds, and methods for utilization of said delivery system, among others, for delivery of genetic drugs into tissues and cells, in vitro, ex vivo, and in vivo, for the treatment of various medical disorders.