CAS: 38267-96-8; 6-Bromo-4-Chloroquinazoline

上下游产品

CAS号32084-59-6 6-溴喹喔啉-4-醇 | CAS号5794-88-7 2-氨基-5-溴苯甲酸 | CAS号16313-66-9 2-氨基-5-溴苯甲酰胺 | CAS号307538-54-1 AURORA 17992 | CAS号307538-52-9 6-溴-4-(4-吗啉)喹唑啉 | CAS号915924-79-7 6-溴-4-甲氧基喹唑啉

📜5-溴氨基苯甲酸甲酯置于三氯氧磷体系中,化学反应 37.0H,反应生成 6-溴-4-氯喹唑啉
参考文献: Substituted Imidazoles For The Inhibition Of Tgf-Beta And Methods Of Treatment[fr] Imidazoles Substitués Pour L'Inhibition De Tgf-Bêta Et Méthodes De Traitement
标题: Substituted Imidazoles For The Inhibition Of Tgf-Beta And Methods Of Treatment[fr] Imidazoles Substitués Pour L'Inhibition De Tgf-Bêta Et Méthodes De Traitement
摘要:这项披露涉及抑制tgf-B信号通路的低分子量取代咪唑化合物.更具体地,这项披露涉及使用上述咪唑化合物治疗与tgf-B信号通路相关的疾病的方法,包括但不限于动脉粥样硬化,马凡综合征,洛伊斯-迪茨综合征,肥胖症,糖尿病,多发性硬化,圆锥角膜,特发性肺纤维化,阿尔茨海默病,慢性肾病和硬皮病.

专利信息

专利号:US-10202374-B2
优先权日:2014-02-27
标题 :6-aryl-4-phenylamino-quinazoline analogs as phosphoinositide-3-kinase inhibitors
发明人：VISHWAKARMA RAM ASREY; BHARATE SANDIP BIBISHAN; BHUSHAN SHASHI; YADAV RAMMOHAN RAO; GURU SANTOSH KUMAR; JOSHI PRASHANT
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to 6-aryl-4-phenylamino quinazolines of formula I wherein, R and R′ are as herein described. The present invention particularly relates to synthesis and anticancer and phoshpoinositide-3-kinase-α (PI3K-α) inhibitory activity. In addition, the invention relates to methods of using compounds for treating or preventing various cancers such as pancreatic, prostate, breast and melanoma.