专利号:WO-2021083438-A1 优先权日:2019-10-30 标 题:Inhibitors of purine nucleoside phosphorylase - synthesis and use thereof for treatment of t-cell acute lymphoblastic leukemia and lymphoma 发明人:SKACEL JAN; JANEBA ZLATKO; MERTLIKOVA KAISEROVA HELENA 权利人:USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V V I 摘要:The present invention relates to new compounds of general formula I, their synthesis, their pharmaceutically acceptable salts, and their use in treatment of T-cell acute lymphoblastic leukemia and lymphoma.
专利号:US-2722526-A 优先权日:1952-09-24 标题:Trialkylphosphites as acid acceptors in the synthesis of amides 发明人:WASHINGTON ANDERSON GEORGE; WILLIAM YOUNG RICHARD 权利人:AMERICAN CYANAMID CO
专利号:US-7250410-B2 优先权日:2001-06-07 标题:Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof 发明人:BOURGUIGNON JEAN-JACQUES; LAGOUGE YAN; LUGNIER CLAIRE; KLOTZ EVELINE; MACHER JEAN-PAUL; RABOISSON PIERRE; SCHULTZ DOMINIQUE 权利人:VIA PHARMACEUTICALS INC 摘要:The invention concerns novel benzodiazepine derivatives and their uses in the field of therapeutics particularly for treating pathologies involving the activity of a cyclic nucleotide phosphodiesterase. It also concerns methods for preparing them and novel synthesis intermediates. The inventive compounds more particularly correspond to general formula (I):
专利号:CN-106631847-B 优先权日:2016-12-26 标 题 :A kind of synthesis technology of preservative intermediate sorbic acid phenylalanine ethyl ester
专利号:CN-104151397-A 优先权日:2014-07-03 标题:A new type of trithiabicyclic organic arsenic compound and its synthesis method and application in the field of anti-tumor
[参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-942. [参考文献]: Andreas J Reichert, Et Al. Optimisation Of A System For The Co-Translational Incorporation Of A Keto Amino Acid And Its Application To A Tumour-Specific Anticalin. Protein Eng Des Sel. 2015 Dec;28(12):553-65.
合成参考文献
参考文献:10.1007/s00726-011-0949-4 摘要:Wang PA, He W, Cheng SK, Zhang SY. Efficient synthesis of unnatural dipeptides based on cis-2,5-disubstituted pyrrolidine. Amino Acids. 2012 Jun;42(6):2121–7. doi: 10.1007/s00726-011-0949-4.