参考标题:Synthesis Of Polyhydroxylated Flavonoids Bearing A Lipophilic Decyl Tail As Potential Therapeutic Antioxidants 作者:Stuart T. Caldwell,Donald B. Mcphail,Garry G. Duthie,Richard C. Hartley |发布日期:2012.1 摘要:Antioxidants Have Potential For The Treatment Of Stroke And Neurodegeneration, And Chimeric Compounds That Combine A Flavon-3-Ol Head Group Related To Myricetin And A Lipophilic Decyl Tail Are Known To Protect Membranes From Oxidative Damage At Least As Well As Vitamin E. New Flavon-3-Ols That Are Highly Hydroxylated In The B Ring In Ways Not Found In Natural Flavon-3-Ols And Bearing A Lipophilic Decyl Tail Have Been Prepared From Trimethoxy- And Tetramethoxybenzoic Acids Accessed By Lithiation-Carboxylation Reactions. Direct Enolate Acylation Was Preferred Over Baker-Venkataraman Rearrangement When There Were Methoxy Groups At Both The 2- And The 6-Position Of The Benzoic Acid Derivatives.
合成参考文献
参考文献:10.1385/abab:129:1:303 摘要:Hong F, Jönsson LJ, Lundquist K, Wei Y. Oxidation capacity of laccases and peroxidases as reflected in experiments with methoxy-substituted benzyl alcohols. Applied Biochemistry and Biotechnology. 2006 Mar;129(1-3):303–19. doi: 10.1385/abab:129:1:303.