CAS: 2380-63-4; 1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine

相似化合物

5444-61-1 5417-78-7 151266-23-8

上下游产品

3-Amino-4-cyanopyrazole formamide 4-chloro-1H-pyrazolo[3,4-d]pyrimidine 1,N1-dimethyl-N2-[4-cyanopyrazol-5-yl]formamidineN1,N1-dimethyl-N2-[4-cyanopyrazol-5-yl]formamidine 1-(2-Benzyloxy-1-benzyloxymethyl-ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine pyrimidine4-bromopyrazolo3,4-dpyrimidine pyrimidine3-bromo-4-aminopyrazolo3,4-dpyrimidine 4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine

在 Ammonium Hydroxide,N,N-二异丙基乙胺体系中,用 四氢呋喃 用作溶剂,化学反应 4.17H,反应生成4-氨基吡唑并[3,4-D]嘧啶
参考文献: Cyclic Di-Nucleotide Compounds And Methods Of Use[fr] Composés Di-Nucléotides Cycliques Et Leurs Procédés D'Utilisation
标题: Cyclic Di-Nucleotide Compounds And Methods Of Use[fr] Composés Di-Nucléotides Cycliques Et Leurs Procédés D'Utilisation
摘要:揭示了环二核苷酸cgamp类似物,合成这些化合物的方法,包括这些化合物的药物组合物,以及在医学治疗中使用这些化合物和组合物的用途.

专利信息

专利号:US-11858953-B2
优先权日:2018-04-04
标 题:Compositions and methods for synthesis of phosphorylated molecules
发明人：CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT
权利人:UNIV CALIFORNIA
摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

专利号:US-10882884-B2
优先权日:2016-05-18
标题:Stereoselective synthesis of phosphorothioate oligoribonucleotides
发明人：HALL JONATHAN; LI MEILING
权利人:ETH ZUERICH
摘要:The present invention relates to chiral phosphoramidites represented by formula (Ia) or formula (Ib) n n n n n n n n n n n n as novel monomers for the synthesis of stereodefined phosphorothioate MOE oligonucleotides. Furthermore, the present invention relates to a method for synthesizing stereodefined phosphorothioate MOE oligonucleotides using said novel chiral phosphoramidites.

专利号:US-11920040-B2
优先权日:2018-05-29
标 题 :Carborhodamine compounds and methods of preparation thereof
发明人：LUKHTANOV EUGENY A
权利人:ELITECHGROUP MDX LLC
摘要:The carborhodamine dyes disclosed herein are novel reagents suitable for automated incorporation of carborhodamine dyes into oligonucleotides that can be used in detection methods for nucleic acid targets. This disclosure provides an efficient and simple process for the preparation of carborhodamine compounds and introduces previously unknown reagents for the automated synthesis of oligonucleotide-carborhodamine conjugates.

专利号:US-7635772-B2
优先权日:2002-12-18
标 题 :Process for the preparation of oligonucleotides
发明人：MCCORMAC PAUL
权利人:AVECIA BIOTECHNOLOGY INC
摘要:A process for the synthesis of an oligonucleotide is provided in which an oligonucleotide is assembled on a swellable solid support using the phosphoramidite approach in the presence of an activator, wherein the activator is not tetrazole or a substituted tetrazole. Preferred activators are pyridinium, imidazolinium and benzimidazolinium salts; benzotriazole and derivatives thereof; and saccharin or a saccharin derivative. Preferred swellable solid supports comprise functionalised polystyrene, partially hydrolysed polyvinylacetate or poly(acrylamide).

专利号:WO-2020117135-A1
优先权日:2018-12-04
标 题:A process for preparation of 1h-pyrazolo[3,4-d] pyrimidine derivatives
发明人：HAAS PHILIPP DANIEL; STECKEL ANDREAS HARTWIG; BELLUR ATICI ESEN; ALTUNDAS RAMAZAN; OZTURK AYDIN BUSRA; SECEN HASAN; AYDIN BUSRA NUR
权利人:DEVA HOLDING AS
摘要:The present invention relates to an efficient and industrially advantageous process for the preparation of 1H-pyrazolo[3,4-d] pyrimidine derivatives. In particular the present invention provides a process for the preparation of 4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4- d]pyrimidine and tert-butyl (R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4- d]pyrimidin-1-yl)piperidine-1-carboxylate. Said compounds are important intermediates in the synthesis of ibrutinib. The method provided for preparing intermediates of ibrutinib has the advantages of a simple operation, high yield and low costs.

专利号:US-9790531-B2
优先权日:2012-08-14
标 题 :Enzymes and polymerases for the synthesis of RNA
发明人：WANG YUXUN; RAMAKRISHNAN DIVAKAR; DE FOUGEROLLES ANTONIN; WHORISKEY SUSAN
权利人:MODERNATX INC
摘要:The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.