CAS: 219873-06-0; 3-Fluoro-4-(Hydroxymethyl)Benzonitrile

上下游产品

CAS号164149-28-4 4-氰基-2-氟苯酸 | CAS号188582-62-9 4-溴-2-氟苄醇 | CAS号105942-10-7 4-氰基-2-氟苯甲醛 | CAS号175596-01-7 4-氰基-2-氟苯甲酸甲酯 | CAS号557-21-1 氰化锌 | CAS号219873-05-9 4-cyano-2-fluor... | CAS号105942-09-4 4-(溴甲基)-3-氟苯腈 | CAS号105942-10-7 4-氰基-2-氟苯甲醛

4-氰基-2-氟苄基乙酸酯置于sodium Methylate体系中,用 甲醇 用作溶剂,以99%的收率获得4-氰基-2-氟苄醇
参考文献:γ-分泌酶抑制剂bms-708163的合成
标题:γ-分泌酶抑制剂bms-708163的合成
摘要:据报道,Bms-708163的简明,会聚外消旋合成.在分开的罐中制备由n-4-氯苯基磺酰基-3,3,3-三氟丙基甘氨酸和2-氟苄醇的1,2,4-恶二唑衍生物组成的两个片段,然后通过mitsunobu反应偶联在一起.由于使用schöllkopf试剂烷基化开发了光学纯的(d)-3,3,3-三氟丙基甘氨酸甲酯的便捷手性合成方法,因此该方法也可用于bms-708163的对映选择性合成.
Doi:10.1016/j.Tetlet.2010.10.025

专利信息

专利号:WO-2021018023-A1
优先权日:2019-08-01
标题:Small molecule glp-1 receptor modulator
发明人：XIE FANG; YU GUANGXIA; ZHANG SHUJUAN
权利人:THE TITAN LEADING MED TECH INC
摘要:The present invention provides a new compound for modulating a Glucagon-like peptide-1 (GLP-1) receptor, and a synthesis method therefor and a pharmaceutical use thereof. This kind of compound has an obvious agonistic effect on the GLP-1 receptor, but does not have an obvious binding effect on hERG, and therefore, it is indicated that the compound has a low risk of cardiotoxicity. The compound of the present invention can be used alone as a treatment medication for type II diabetes, or be used in combination with a polypeptide GLP-1 receptor agonist such as liraglutide, or be used in combination with the treatment medication for type II diabetes of other mechanisms.