CAS: 20577-26-8; 2-Bromonicotinonitrile

相似化合物

128071-75-0 35905-85-2 374633-37-1

上下游产品

2-hydroxy-3-cyanopyridine phosphorus pentaoxide 2-chloro-3-pyridinecarbonitrile 3-cyanopyridine N-oxide ethyl 2-(3-cyanopyridin-2-yl)acetate pyridine carboxylathe d,ethyle-2amino-3 thieno2,3-c pyridine carboxylathe d,ethyle-2 ethyl 3-aminothieno[2,3-b]pyridine-2-carboxylate benzyl(cyano-3 pyridyl-2) sulfure

2-羟基-3-氰基吡啶置于四丁基溴化铵,Phosphorus Pentoxide体系中,用 甲苯 用作溶剂,化学反应 4.5H,反应生成2-溴-3-氰基吡啶
参考文献:Spiro Compounds
标题:Spiro Compounds
摘要:通式(i)的螺环化合物:其中ar1代表可选择取代的芳基或杂环芳基;N代表0或1;T,U,V和w分别代表氮原子或可选择取代的甲基基团,其中至少两个代表所述的甲基基团;X代表甲基;Y代表可选择取代的亚胺基或氧原子.这些新型螺环化合物表现出神经肽y受体(npy)拮抗活性,并可用作治疗与npy相关的各种疾病的药物,例如心血管疾病,中枢神经系统疾病,代谢性疾病等.

专利信息

专利号:EP-1641453-B1
优先权日:2003-06-25
标题 :Product containing at least one phosphatase cdc25 inhibitor combined with at least one other anticancer agent
发明人：PREVOST GREGOIRE; BREZAK PANNETIER MARIE-CHRISTINE; DIOLEZ CHRISTIAN
权利人:IPSEN PHARMA
摘要:The invention relates to a product containing at least one phosphatase Cdc25 inhibitor combined with at least one other anticancer agent for simultaneous, separate or staggered therapeutic use during treatment for cancer. According to the invention, the other anticancer agent is preferably selected from: DNA base analogs such as 5-fluorouracil; inhibitors of type I and/or type II topoisomerases, such as camptothecin and the analogs thereof, doxorubicin or amsacrine; compounds interacting with the cellular spindle, for example, paclitaxel (Taxol); compounds acting on the cytoskeleton, such as vinblastine; inhibitors of the transduction of the signal passing via the heterotrimeric G proteins; prenyltransferase inhibitors, and especially farnesyltransferase inhibitors; cyclin-dependent kinase (CDKs) inhibitors; alkylating agents such as cisplatin; folic acid antagonists such as methotrexate; and inhibitors of DNA synthesis and cellular division, such as mitomycin C. The invention also relates to (1R)-1-[({(2R)-2-amino--3-[(8S)-8-(cyclohexylmethyl)-2-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]--3-oxopropyl}dithio)methyl]-2-[(8S)-8-(cyclohexylmethyl)-2-phenyl--5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]-2-oxoethylamine, or the pharmaceutically acceptable salts thereof, that can be used as anticancer agents.

专利号:CN-105061435-A
优先权日:2015-08-27
标题 :Monomer of pyrrolopyrrolidone unit and its synthesis method and polymer