CAS: 2034-74-4; (3S,8S,9S,10R,13R,14S,17R)-17-((2R,5R)-5-Ethyl-6-Methylheptan-2-yl)-3-Hydroxy-10,13-Dimethyl-1,2,3,4,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-7H-Cyclopenta[a]Phenanthren-7-One

上下游产品

(24R)-3β-acetoxystigmast-5-en-7-one β-sitosterol stigmast-5-en-3-yl acetate 5-stigmasten-3β,7β-diol

📜豆甾醇置于叔丁基过氧化氢,Di-μ-Hydroxo-Bis[(N,N,N',N'-Tetramethylethylenediamine)Copper(II)] Chloride体系中,用 甲醇,癸烷,二氯甲烷 用作溶剂,化学反应 40.0H,以52%的收率获得7-氧代-Beta-谷甾醇
参考文献:迅速合成菠菜甾醇和舒腾醇,坚果油和仙人掌梨子籽油中存在的两种植物甾醇,并评估它们对中枢神经系统细胞的生物学活性.
标题:迅速合成菠菜甾醇和舒腾醇,坚果油和仙人掌梨子籽油中存在的两种植物甾醇,并评估它们对中枢神经系统细胞的生物学活性.
摘要:菠菜甾醇和叔丁醇,存在于摩洛哥坚果油和仙人掌梨种子油中的两种植物甾醇,是通过四步反应从市售的豆甾醇中合成的.此外,分别用结晶紫试验和mtt试验评价了158N鼠少突胶质细胞,C6大鼠神经胶质瘤细胞和sk-N-Be人神经元细胞对这些植物甾醇对细胞生长和线粒体活性的影响.比较了spinasterol和schottenol与7-Ketocholesterol(7Kc)和阿魏酸的作用,阿甘和仙人掌梨种子油中也存在阿魏酸.无论考虑哪种细胞,均观测到了7Kc的剂量依赖性细胞毒性作用,而未发现或仅存在阿魏酸的轻微作用.用菠菜甾醇和舒腾醇,未检测到或对细胞生长有轻微影响.与菠菜甾醇,在158N和c6细胞上发现线粒体活性降低(30-50%);没有发现对sk-N-Be有影响.使用舒腾醇后,在158N(50%)和c6(10-20%)细胞上线粒体活性降低.没有发现对sk-N-Be有影响.总而言之,这些数据表明,菠菜
Doi:10.1016/j.Steroids.2015.01.005

专利信息

专利号:EP-1493431-B1
优先权日:2003-07-03
标题:Use of an extract of bauhinia for the preparation of pharmaceutical and cosmetic compositions
发明人：WIRTH CORINNA DR; BUCHHOLZ HERWIG DR
权利人:MERCK PATENT GMBH
摘要:Use of an aqueous or aqueous-alcoholic extract (A) of Bauhinia is claimed to make a composition for cosmetic or pharmaceutical treatment of skin and hair. Use of an aqueous or aqueous-alcoholic extract (A) of Bauhinia is claimed to make a composition for: (a) care, preservation or improvement of the general condition of the skin or hair; (b) prevention and/or inhibition of the aging process for human skin or hair; (c) for promoting healing of wounds; (d) for prevention and/or treatment of skin diseases associated with abnormal keratinization, and (e) for prevention and/or treatment of all malignant or benign growths of the dermis or epidermis. An independent claim is also included for a composition containing (A). ACTIVITY : Dermatological; Vulnerary; Antiseborrheic; Antipsoriatic; Cytostatic; Antiinflammatory; Virucide. MECHANISM OF ACTION : Protein glycosylation inhibitor. In a test, human fibroblasts were cultured in the presence of Vitamin C to stimulate collagen synthesis, then lysed and labeled with tritiated glucose for 15 days, Proteins were removed, extraction and precipitation were carried and the amount of bound glucose measured by liquid scintillation counting. Addition of an aqueous-alcoholic extract of Bauhinia fortificata (0.03 mg/ml), reduced protein glycosylation to 55% of that in a control.