CAS: 166671-26-7; 2-(2-Hydroxyethyl)-3-Methyl-1-Oxo-1,5-Dihydrobenzo[4,5]Imidazo[1,2-A]Pyridine-4-Carbonitrile

相似化合物

714212-16-5 750599-25-8 121105-77-9

上下游产品

CAS号517-23-7 2-乙酰基-γ-丁内酯 | CAS号4414-88-4 2-苯并咪唑基乙腈

📜α-乙酰基-γ-丁内酯,2-氰甲基苯并咪唑置于乙酸铵体系中,化学反应 1.0H,以90%的收率获得2-(2-羟基乙基)-3-甲基-1-氧代-1,5-二氢吡啶并[1,2-A]苯并咪唑-4-甲腈
参考文献:Benzimidazole Condensed Ring System. Ix. Potential Antineoplastics. New Synthesis Of Some Pyrido[1,2-α]Benzimidazoles And Related Derivative
标题:Benzimidazole Condensed Ring System. Ix. Potential Antineoplastics. New Synthesis Of Some Pyrido[1,2-α]Benzimidazoles And Related Derivative
摘要:Some Pyrido[1,2-A]Benzimidazoles Were Prepared In Order To Investigate Their In Vitro Antineoplastic And Anti-Hiv Activities. Two Compounds (9B,Nsc 658526 And 15,Nsc 664715) Showed A Variable Degree Of Antineoplastic Activity Against Some Of The Cell Lines Tested. Compound 9A (Nsc 649900) Exhibited A Good In Vitro Antineoplastic Activity With Subpanel Disease Selectivity,Particularly Against Most Of The Cell Lines Of Leukemia And Some Cell Lines From Colon,Melanoma And Renal Cancer Panels.
Doi:10.1016/0223-5234(96)88241-9

专利信息

专利号:US-2005113397-A1
优先权日:2002-01-31
标题:Imidazo[1,2-a]pyridine derivative
发明人：TAKEMURA MAKOTO; TAKAHASHI HISASHI; KAWAKAMI KATSUHIRO; TAKESHITA HIROSHI; KIMURA YOUICHI; WATANABE JUN; SUGIMOTO YUICHI; KITAMURA AKIHIRO; NAKAJIMA RYOHEI; KANAI KAZUO; FUJISAWA TETSUNORI
摘要:A compound reprsented by the following formula (I), its salts or nsolvates thereof capable of specifically or selectively expressig an antifungal activity in a broad spectrum based on the novel mechanism thereof of 1,6-β-glucan synthesis inhibition, and an antifungal agent containing any of them.