CAS: 15307-93-4; 2,6-Dichloro-N-Phenylaniline

相似化合物

1205-40-9 15362-44-4 58373-59-4

上下游产品

N-phenyl-2,2,6,6-tetrachlor°Cyclohexaneimine 1-bromo-2,6-dichlorobenzene aniline bromobenzene [(2,6-Dichloro-phenyl)-phenyl-amino]-oxo-acetyl chloride N-(2,6-dichlorophenyl)-α-(methylthio)acetanilide 2-chloro-N-(2',6'-dichlorophenyl)-N-phenylacetamide 1-(2,6-dichlorophenyl)indolin-2-one

2,6-二氯苯酚置于sodium Hydroxide体系中,用 水,甲苯,苯 用作溶剂,化学反应 31.0H,反应生成2,6-二氯-N-苯基苯胺
参考文献:一种双氯芬酸锌的合成方法
标题:一种双氯芬酸锌的合成方法
摘要:本发明涉及一种双氯芬酸锌的合成方法,属于药物的化学合成领域.以苯胺为原料,在乙酰氯的作用下和2,6‑二氯苯酚反应,得2‑(2,6‑二氯苯氧)‑n‑苯乙酰胺,其在无机碱的作用下制备n‑(2,6‑二氯苯基)苯胺,该化合物在氯乙酰氯作用下,再经环合反应制备1‑(2,6‑二氯苯基)‑2‑吲哚酮,1‑(2,6‑二氯苯基)‑2‑吲哚酮经水解等反应合成双氯芬酸锌.本发明成本低,收率高,总收率70%,尤其是反应条件温和,绿色环保,在反应过程所产生的盐酸气等废气均使用吸收系统被较好地吸收,因此具有非常好的工业化前景.

专利信息

专利号:US-6593347-B2
优先权日:1998-10-30
标题 :Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
发明人：BANDARAGE UPUL K; DONG QING; FANG XINQIN; GARVEY DAVID S; MERCER GREGORY J; RICHARDSON STEWART K; SCHROEDER JOSEPH D; WANG TIANSHENG
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.

专利号:US-10662145-B2
优先权日:2018-08-17
标题:Method of synthesizing diclofenac sodium
发明人：CHEN FENER; WANG LINGDONG; MENG GE; HUANG ZEDU; CHENG DANG; PENG HAIHUI; LIANG GUANFENG
权利人:UNIV FUDAN
摘要:The invention relates to the chemical synthesis of pharmaceutical API, and specifically to a method of synthesizing diclofenac sodium, which is a kind of nonsteroidal anti-inflammatory drug for relieving pain. The method includes: nitrating phenylacetate to prepare o-nitrophenylacetate (2); hydrogenating o-nitrophenylacetate (2) to prepare o-aminophenylacetate (3); amidating an amino group of o-aminophenylacetate (3) to obtain 2-(2-benzoylaminophenyl) acetate (4); 2-(2-benzoylaminophenyl) acetate (4) reacting with thionyl chloride to prepare a chloroimine intermediate, and then condensing the intermediate of chloroimine with 2,6-dichlorophenol using an inorganic base to prepare (E)-methyl-2-(2-((2,6-dichlorophenoxy)(phenyl)methyleneamino) phenyl ester (5); subjecting (E)-methyl-2-(2-((2,6-dichlorophenoxy)(phenyl)methyleneamino) phenyl ester (5) to Chapman rearrangement to afford methyl 2-(2-(N-(2,6-dichlorophenyl)benzoylamino)phenyl) ester (6); and hydrolyzing methyl 2-(2-(N-(2,6-dichlorophenyl)benzoylamino)phenyl) ester (6) to provide the target compound as of diclofenac sodium API. The overall yield is up to 67% based on methyl phenylacetate.

专利号:EG-21151-A
优先权日:1992-07-28
标题:A convenient facile synthesis of 2,6-dichlorod-iphenylamine the key intermediate for the synthesis of 0-(2,6 dichloroanilino) phenylacetic acid diclofenac voltaren) utilizing the firstly reported n- formyl-2,6-dichlorodiphenylamine

专利号:CN-111100057-A
优先权日:2019-12-04
标 题:Synthesis method of diclofenac sodium intermediate 1-(2,6-dichlorophenyl)indoline-2-one

专利号:CN-114539086-B
优先权日:2022-02-25
标题 :Synthesis method of diclofenac sodium

专利号:CN-113429308-A
优先权日:2021-06-16
标题 :The synthesis process of diclofenac sodium