CAS: 12236-82-7; 1-Amino-4-[[4-[[4-Chloro-6-[[3(Or 4)-Sulfophenyl]Amino]-1,3,5-Triazin-2-Yl]Amino]-3-Sulfophenyl]Amino]-9,10-Dihydro-9,10-Dioxo-2-Anthracenesulfonic Acid

专利信息

专利号:WO-9405797-A1
优先权日:1992-09-01
标题 :Synthesis of dna molecules in vitro
发明人：KISELEV VSEVOLOD; SEVERIN EVGENII; KORPELA TIMO
权利人:KISELEV VSEVOLOD; SEVERIN EVGENII; KORPELA TIMO
摘要:The present invention is directed on a composition of thermophilic enzymes as a tool for DNA synthesis in vitro, the composition comprising, in combination, an enzyme being capable of carrying out the polymerization of dNTP to form de nova synthesized DNA molecules within the temperature interval of 56-90 °C (thermophilic DNA-polymerase) and an enzyme being capable of eliminating accumulated pyrophosphate (thermophilic pyrophosphatase) within the same temperature interval. The invention is also directed on the preparation and the use of the said composition.

专利号:US-4752638-A
优先权日:1983-11-10
标 题:Synthesis and use of polymers containing integral binding-pair members
发明人：NOWINSKI ROBERT C; HOFFMAN ALLAN S; HOUGHTON RAYMOND L; PRIEST JOHN H; MONJI NOBUO
权利人:GENETIC SYSTEMS CORP
摘要:Conjugate monomers, polymers, and methods for the de novo synthesis of the polymers are provided. Conjugate organic monomers contain binding-pair members which upon polymerization become integrally associated with the resultant polymer. Specifically, antigens, antibodies, receptors, and ligands may be bound to organic monomers either directly by chemical reaction or indirectly by chemical spacer arms, and these conjugates may be polymerized or copolymerized with nonderivatized monomers to form polymers containing variable amounts of the binding-pair members. Such conjugate monomers and polymers find a wide variety of uses in binding to their binding-pair-member cognate which include selective removal of complementary binding-pair members from solution as well as in immunoassay procedures and in immunization regimes.

专利号:US-6350612-B1
优先权日:1986-01-28
标 题 :Isolation and expression of DNA sequence encoding the five subunits of Bordetella pertussis toxin
发明人：RAPPUOLI RINO; NICOSIA ALFREDO; ARICO MARIA BEATRICE
权利人:CHIRON SPA
摘要:Cloning and sequencing of the Eco RI fragment of B. pertussis chromosomal DNA with 4696 base pairs, containing the genes which code for the five subunits of the pertussis toxin. A hybrid plasmid containing the DNA fragment or its further fragments and a micro-organism transformed by the hybrid plasmid and capable of expressing the cloned DNA fragment or further fragments thereof by synthesis of the pertussis toxin or one or more subunits of the pertussis toxin. The pertussis toxin or one or more subunits of the pertussis toxin so obtained are useful for the preparation of vaccines and diagnostic kits.

专利号:EP-0658564-B1
优先权日:1986-04-30
标题 :Electroluminescent compounds and intermediates in their synthesis
发明人：MASSEY RICHARD J; POWELL MICHAEL J; MIED PAUL A; POONIAN MOHINDAR S; FENG PETER; CIANA LEOPOLDO DELLA; DRESSICK WALTER J
权利人:IGEN INT INC
摘要:Novel compounds for use in electrochemiluminescent assays and characterised by containing the structure        X - Y - ZwhereinX represents one or more nucleotides which may be the same or different, one or more amino acids which may be the same or different, an antibody, an analyte of interest or an analogue of an analyte of interestY represents a linker group attached to X and Z,andZ represents an electrochemiluminescent moiety, and intermediates employed in their synthesis.

专利号:US-6534530-B1
优先权日:1999-08-04
标题:Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
发明人：DRAGOVICH PETER SCOTT; ZHOU RU; WEBBER STEPHEN EVAN; PRINS THOMAS J; REICH SIEGFRIED HEINZ; KEPHART SUSAN E; RUI YUANJIN
权利人:AGOURON PHARMA
摘要:Compounds of the formula:where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-8574543-B2
优先权日:2007-12-14
标题 :Method of isotope labeling and determining protein synthesis, quantitation and protein expression
发明人：LEE WAI-NANG P; XIAO GUISHAN
权利人:LEE WAI-NANG P; XIAO GUISHAN; LOS ANGELES BIOMED RES INST
摘要:A method including isotope labeling of a newly synthesized protein in a sufficient quantity such that a newly synthesized protein spectra and the pre-existing protein spectra are sufficiently separated. A further method including determining a ratio of a new and a pre-existing protein from mass spectra obtained by using mass spectrometry. In this method a resultant spectrum may be presented as integrated peak heights for a corresponding mass to charge ratio in the “centroidâ€? mode.