CAS: 120205-50-7; (2R,3R)-3-((S)-1-(Tert-Butoxycarbonyl)Pyrrolidin-2-yl)-3-Methoxy-2-Methylpropanoic Acid

相似化合物

133164-08-6 157967-07-2 157967-06-1

上下游产品

(S)-Tert-Butyl 2-((1R,2R)-1,3-Dimethoxy-2-Methyl-3-Oxopropyl)Pyrrolidine-1-Carboxylate 179039-97-5
(2R,3R)-3-[(2S)-1-[(叔丁氧基)羰基]吡咯烷-2-基]-3-羟基-2-甲基丙酸 (2R,3R)-3-[(2S)-1-[(Tert-Butoxy)Carbonyl]Pyrrolidin-2-Yl]-3-Hydroxy-2-Methylpropanoic Acid 133565-38-5
(S)-1-Boc-2-((1R,2R)-1-羟基-2-甲基丙酸甲酯)基吡咯 N-Boc-Dolaproine-Methyl 164456-57-9
Ethyl (2R,3R,4S)-3-(N-Tert-Butoxycarbonyl-2'-Pyrrolidinyl)-3-Hydroxy-2-Methylpropanoate 135383-58-3
Ethyl (2S,3R,4S)-3-(N-Tert-Butoxycarbonyl-2'-Pyrrolidinyl)-3-Hydroxy-2-Methylpropanoate 135500-35-5
(S)-2-((1R,2R)-3-(苄氧基)-1-甲氧基-2-甲基-3-氧代丙基)吡咯烷-1-甲 Benzyl (2R,3R,2'S)-3-(N-Tert-Butoxycarbonyl-2'-Pyrrolidinyl)-3-Methoxy-2-Methylpropanoate 149606-97-3
(S)-2-((1R,2R)-3-(苄氧基)-1-羟基-2-甲基-3-氧代丙基)吡咯烷-1-甲酸 Benzyl (2R,3R,2'S)-3-(N-Tert-Butoxycarbonyl-2'-Pyrrolidinyl)-3-Hydroxy-2-Methylpropanoate 163768-51-2
Tert-Butyl (2S)-2-[(1R,2S)-1-Methoxy-2-Methylbut-3-En-1-Yl]Pyrrolidine-1-Carboxylate 159173-43-0 (2S,1'R,2'S)-N-(Tert-Butoxycarbonyl)-2-(1'-Hydroxy-2'-Methyl-3'-Butenyl)-Pyrrolidine 159173-40-7 Tert-Butyl 2-(2-(Methoxycarbonyl)-1-Hydroxyallyl)Pyrrolidine-1-Carboxylate 602325-71-3

(S)-T-Butyl 2-((1R,2R)-1-Methoxy-2-Methyl-3-Oxo-3-((R)-2-Oxo-4-Phenyloxazolidin-3-yl)Propyl)Pyrrolidine-1-Carboxylate置于双氧水,Lithium Hydroxide,Sodium Sulfite体系中,用 四氢呋喃 用作溶剂,化学反应 19.0H,以99%的收率获得((2R,3R)-3-((S)-1-(Tert丁氧基羰基)吡咯烷-2-基)-3-甲氧基-2-甲基丙酸
参考文献:Dolastatin-10 Derivative,Method Of Producing Same And Anticancer Drug Composition Containing Same
标题:Dolastatin-10 Derivative,Method Of Producing Same And Anticancer Drug Composition Containing Same

专利信息

专利号:US-6569834-B1
优先权日:1992-12-03
标 题 :Elucidation and synthesis of antineoplastic tetrapeptide w-aminoalkyl-amides
发明人：PETTIT GEORGE R; BARKOCZY JOZSEF
摘要:Dolastatin 10, a linear pentapeptide, has shown potent antineoplastic activity profiles against various experimental cancer systems. The synthesis of structural modifications of dolastatin 10 having significant antineoplastic activity against human cancer cell lines has been accomplished; namely antineoplastic tetrapeptide w-amino alkyl amides related to dolastatin 10, which have been found to demonstrate effective antineoplastic activity against various human cancer cell lines. Members of this have demonstrated significant antineoplastic activity against human cancer cell lines. The human cancer cell lines against which the substances of the present invention have yielded the significant antineoplastic activity are: Ovarian OVCAR-3; Central Nervous System ('CNS') SF295; Renal A498; Lung NCI460; Colon KM20L2 and Melanoma SK-MEL-3.

专利号:CN-111393346-B
优先权日:2020-06-02
标题:Synthesis of N-Boc-Dolaproine and Boc-Dap DCHA

专利号:CN-111393346-A
优先权日:2020-06-02
标 题:Synthesis method of N-Boc-Dolaprine and Boc-Dap DCHA