CAS: 103041-38-9; Ethyl 3-(Pyridin-2-Ylamino)Propanoate

相似化合物

55364-85-7 103041-38-9 19068-80-5

上下游产品

2-aminopyridine 4-tert-Butylcatechol ethyl acrylate ethanolethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate ethyl 3-[[4-(methylamino)-3-nitrobenzoyl](pyridin-2-yl)amino]propanoate hydr°Chloride 3-({2-[(4-carbamimidoylphenylamino)methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}pyridin-2-yl-amino)propionic acid ethyl ester dabigatran etexilate

2-氨基吡啶,丙烯酸乙酯置于咪唑盐酸盐体系中,用 Neat (No Solvent) 用作溶剂,化学反应 5.0H,以33%的收率获得3-(吡啶-2-基氨基)丙酸乙酯
参考文献:氯化咪唑鎓催化迈克尔加成反应保护氨基并构建中环杂环
标题:氯化咪唑鎓催化迈克尔加成反应保护氨基并构建中环杂环
摘要:已经开发出一种有效的氨基保护和七元环构建方法.该方法采用氯化咪唑在低温下进行迈克尔加成反应,在高温下进行氨基脱保护或构建七元环.
Doi:10.3390/molecules24234224

专利信息

专利号:US-9533971-B2
优先权日:2012-10-29
标 题 :Process for the synthesis of dabigatran and its intermediates
发明人：PULLAGURLA MANIK REDDY; RANGISETTY JAGADEESH BABU; NANDAKUMAR MECHERIL VALSAN
权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD; BIOPHORE INDIA PHARMACEUTICALS PVT LTD
摘要:The present invention describes an improved process for the preparation of Dabigatran Etexilate (Formula-VII) or it's pharmaceutically acceptable salt for the treatment of thrombosis, cardiovascular diseases etc. and intermediates involved in the synthesis.

专利号:US-10077251-B2
优先权日:2012-10-29
标题:Process for the synthesis of Dabigatran Etexilate and its intermediates
发明人：PULLAGURLA MANIK REDDY; RANGISETTY JAGADEESH BABU; NANDAKUMAR MECHERIL VALSAN
权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD
摘要:The present invention describes an improved process for the preparation of Dabigatran Etexilate (Formula-VII) or it's pharmaceutically acceptable salt for the treatment of thrombosis, cardiovascular diseases etc. and intermediates involved in the synthesis.

专利号:US-9273030-B2
优先权日:2012-04-02
标题 :Process for the preparation of benzimidazole derivatives and salts thereof
发明人：THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; RAGHURAM SURAPARAJU
权利人:MSN LAB PRIVATE LTD
摘要:Provided are novel salts of benzimidazole derivatives, preferably salts of benzimidazole derivatives which are useful intermediates in the synthesis of pure 1-methyl-2-[N-[4-(N-n-hexyloxycarbonylamidino)phenyl]aminomethyl]benzimidazol-5-yl-carboxylicacid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide and its salts.

专利号:US-9688657-B2
优先权日:2013-03-25
标题:Synthesis of dabigatran
发明人：PATKAR LAXMIKANT NARHARI; MONDKAR HARISH KASHINATH; AROTE NITIN DNYANESHWAR; PATIL SACHIN SHIVAJI; JADHAV TANAJI SHAMRAO; HAGAVANE NITIN NIVRUTTI; BHOPALKAR RAJESH GANPAT
权利人:USV PRIVATE LTD
摘要:The present invention relates to a process for preparation of Dabigatran etexilate or pharmaceutically acceptable salt thereof. The present invention relates to novel compounds, in particular Ethyl-3-{[(2-formyl-1-methyl-1H-benzimidazole-5-yl)carbonyl]-(2-pyridinyl) amino}propanoate and Ethyl-3-{[(2-dichloromethyl-1-methyl-1H-benzimidazole-5-yl)carbonyl]-(2-pyridinyl)amino}propanoate and process for preparation thereof. The present invention further relates to the use of these novel compounds in the preparation of Dabigatran etexilate or pharmaceutically acceptable salt thereof.

专利号:CN-117756712-A
优先权日:2023-12-13
标 题:Synthesis of dabigatran etexilate intermediate and preparation method of impurities

专利号:US-2015246900-A1
优先权日:2012-10-29
标题 :Process for the Synthesis of Dabigatran and Its Intermediates