CAS: 98414-56-3; 1,3-Di(1H-1,2,4-Triazol-1-yl)Propan-2-One

上下游产品

î±-(1H-1,2,4-Triazole-1-Ylmethyl)-1H-1,2,4-Triazole-1-Ethanol

📜1H-1,2,4-Triazole,1,1A(2)-[1,3-Dioxolan-2-Ylidenebis(Methylene)]Bis-以89.8的收率获得产物1,3-双(1H-1,2,4-三唑-1-基)-2-丙酮
参考文献:一种氟康唑的新制备方法
标题:一种氟康唑的新制备方法
摘要:一种氟康唑的新制备方法,涉及一种广谱抗真菌药物氟康唑的制备方法.该方法依次包括如下步骤:采用1,3-二溴丙酮作为原料,依次与乙二醇进行缩酮反应,与1H-1,2,4-三氮唑进行取代反应,然后再在强酸存在条件下进行水解反应,最后与预先制备的2,4-二氟溴苯的格式试剂进行反应制得氟康唑,本发明提出了一条全新的合成路线,各步反应条件易于操作,工艺简单,各步反应均为较常规操作,有效的避免了采用价格昂贵的原料,降低了产品的成本.

专利信息

专利号:US-7094904-B2
优先权日:2001-03-23
标题:Process for preparing monohydrate and crystal modifications of fluconazole
发明人：KREIDL NEE REGINA HEGEDUS LEGA; CZIBULA LASZLO; SZANTAY CSABA; FARKAS JENONE; JUHASZ IDA DEUTSCHNE; HEGEDUS ISTVAN; PAPP EVA WERKNE; BAGDY JUDIT NAGYNE; PILLER AGNES
权利人:RICHTER GEDEON VEGYESZET
摘要:A new process is disclosed for the synthesis of fluconazole monohydrate and for crystal modifications of fluconazole which comprises the step ofn hydrolyzing a silyl ether of the formula (II) nn n n n n n n n n n n n  whereinn R 2 is hydrogen, or a C 1 to C 10 alkyl or phenyl group, R 3 and R 4 independently of each other are a C 1 to C 10 alkyl or phenyl group in an aqueous solution, preferably at a pH below 3 or above 8.

专利号:US-5304568-A
优先权日:1992-04-14
标题:Ethyl-triazolyl derivatives
发明人：SCHERKENBECK JUERGEN; LINDEMANN MICHAEL; DUTZMANN STEFAN; DEHNE HEINZ-WILHELM
权利人:BAYER AG
摘要:New ethyl-triazolyl derivatives of the formula (I) in which R represents halogen, X1 represents fluorine, chlorine or bromine, X2 represents fluorine, chlorine or bromine, Z represents halogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, ethyl having 1 or 2 carbon atoms and 1 to 5 halogen atoms, halogenoalkoxy having 1 or 2 carbon atoms and 1 to 5 halogen atoms, phenyl, phenoxy, nitro or alkoximinoalkyl having 1 to 4 carbon atoms in the alkoxy moiety and 1 to 4 carbon atoms in the alkyl moiety and m represents the numbers 0, 1, 2 or 3, and addition products thereof with acids or metal salts are very effective for combating fungi. Novel ethyl-triazolyl derivatives of the formula (II) in which R, Z and m have the abovementioned meanings, and addition products thereof with acids or metal salts are very effective for combating fungi. The ethyl-triazolyl derivatives of the formula (II) are also valuable intermediates for the synthesis of ethyl-triazolyl derivatives of the formula (I).

专利号:US-5097050-A
优先权日:1988-07-19
标题 :Aryl-alkinyl halocycloalkyl oxiranes
发明人：LANTZCSH REINHARD; KYSELA ERNST; BUECHEL KARL H; DUTZMANN STEFAN; BRANDES WILHEIM; HAENSSLER GERD
权利人:BAYER AG
摘要:An oxirane of the formula ##STR1## in which Ar represents phenyl optionally substituted with from one to three halogen atoms, n R represents alkyl having from 1 to 4 carbon atoms, n X 1 represents halogen, n X 2 represents hydrogen or halogen, n X 3 represents hydrogen or halogen, n X 4 represents hydrogen or halogen and n n represents 0 to 1, n useful as intermediates for the synthesis of fungicidal hydroxyalkinyl-azoles.

专利号:CN-112010813-B
优先权日:2020-09-18
标题:Synthesis method and application of prothioconazole