CAS: 941-69-5; N-Phenylmaleimide

• 英文名称N-Phenylmaleimide
• 中文名称N-苯基马来酰亚胺
• IUPAC名称1-phenyl-1H-pyrrole-2,5-dione
• 其它别名1-苯基的-1H-吡咯-2,5-二酮; N苯基马来酰亚胺; N-Phenylmaleimide 1-Phenyl-1H-Pyrrole-2,5-Dione
• CAS编号941-69-5
• MFCD编号:MFCD00005502
• EINECS号:213-382-0
• FDA UNII编号:9U9KT462VW
• 分子式:C10H7NO2
• 分子量:173.17
• 产品CID: 1989440
• 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

• 相似结构搜索
• 产品信息参考
• InChIKey: HIDBROSJWZYGSZ-UHFFFAOYSA-N
• InChI=1S/C10H7NO2/c12-9-6-7-10(13)11(9)8-4-2-1-3-5-8/h1-7H…
• 计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数1.0

物理性质

• 熔点85-87°C
• 沸点162-163 °C at 12 mmHg
• 闪点152°C
• 密度1.3±0.1 g/cm3
• pKa:-0.81±0.20(预测)
• PSA:37.38
• LogP:1.116
• 折射率1.630
• 蒸汽压0.0±0.6 mmHg at 25°C
• 溶解性815G/l Insoluble
• 敏感性常温常压下稳定，避免氧化物接触
• 外观形态黄色结晶粉末或薄片状物
• 储存条件密封, 常温干燥保存
• 产品应用N-苯基马来酰亚胺(N-PMI)在天然橡胶和合成橡胶中可作为硫化交联剂,在ABS,PVC,PMMA树脂和感光材料中作为耐热改性剂,可提高树脂的耐热性,耐冲击性,热熔性和加工性等.N-PMI可用作树脂中间体,用来制造耐热聚合物,植物生长促进剂等农用化学品,N-PMI还有一定的抗菌活性.
• 性质描述淡黄色片结晶体;熔点86.0～90.0°C,难溶于水,易溶于乙醇,丙酮和甲苯等.质量标准:项目(Itme)指标外观(Appearance)浅黄色结晶(yellowcrystal)纯度(Purity)≥99.5(99.5min)熔点(Meltingpoint)86-90°C酸值(Acidvalue)≤1.0KOHmg/g

MSDS等安全信息

• GHS象形图
• GHS符号GHS06 & GHS05 & GHS09;
  注释: Skull and crossbones & Corrosion & Environment
• 危险类别急性毒性 类别3(经口)
  皮肤腐蚀/刺激 类别2
  严重眼损伤 类别1
  皮肤致敏 类别1
  水生急性毒性 类别1
  水生慢性毒性 类别1
  急性毒性 类别1(吸入)
  特定目标器官毒性 - 单次接触 类别3
  严重眼刺激 类别2
  水生慢性毒性 类别2
  特定目标器官毒性-单次接触 类别1
  急性毒性 类别3(吸入)
• 警示词Danger(危险)
• 危险描述H301 |吞咽会中毒.
  H315 |造成皮肤刺激.
  H318 |造成严重眼损伤.
  H317 |可能引起皮肤过敏反应.
  H400 |对水生生物毒性极大.
  H410 |对水生生物毒性极大并具有长期持续影响.
  H330 |吸入致命.
  H335 |可能引起呼吸道刺激.
  H319 |造成严重眼刺激.
  H411 |对水生生物有毒并具有长期持续影响.
  H370 |损害器官.
  H331 |吸入会中毒.
• 防范说明P264-P270-P273-P330-P391-P405-P501
• 危险等级6.1
• UN编号2811.0
• 危险品标志T,Xi,N
• 风险等级Irritant
• 包装等级Ⅲ
• 安全声明45-24/25-36/37/39-26-61-39-36/37
• 危险类别码25-36/37/38-23/24/25-50-43-41-38
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 555-59-9 = 941-69-5
  反应条件:1.1 Catalysts: Sulfobetaine Methacrylate Solvents: Methyl Isobutyl Ketone,Water; 20 S,100 °C; 35 S,100 °C; 150 S,100 °C
  标题:Preparation Of N-Substituted Maleimide In Microchannel Reactor
  参考文献:China]
  
  108-31-6 = 941-69-5
  反应条件:1.1 Solvents: Acetic Acid; 10 Min,Rt1.2 Reagents: Sulfuric Acid; Rt -> 60 °C; 45 Min,60 °C; 60 °C -> Rt1.3 Reagents: Water; Cooled1.4 Reagents: Sodium Bicarbonate Solvents: Water; 10 Min
  标题:Dabco-Catalyzed [3+2] Cycloaddition Reactions Of Azomethine Imines With N-Aryl Maleimides: Facile Access To Dinitrogen-Fused Heterocycles
  作者:Jia,Qianfa; Chen,Lei; Yang,Gongming; Wang,Jian; Wei,Jia; Et Al
  参考文献:Tetrahedron Letters 日期:2015 卷标:56(52) 页码:7150-7153]
  
  108-31-6 = 941-69-5
  反应条件:1.1 Solvents: Acetic Acid; 10 Min,Rt1.2 Reagents: Sulfuric Acid Solvents: Water; Rt -> 60 °C; 45 Min,60 °C; 60 °C -> Rt; Cooled1.3 Reagents: Sodium Bicarbonate Solvents: Water; 10 Min,Rt
  标题:Synthesis Of Substituted N-Aryl Pyrrolo-Quinolines And Study Of Their Antimicrobial Activities
  作者:Deshmukha,Ganesh B.; Patila,Nilesh S.; Gaikwada,Vishwas B.; Bholeb,Avinash D.; Patila,Sambhaji V.
  参考文献:Journal Of Chemical And Pharmaceutical Research 日期:2014 卷标:6(8) 页码:393-399]
  
  2851450-77-4 = 941-69-5
  反应条件:1.1 Solvents: Xylene; 4 H,150 °C
  标题:Green Preparation Of N-Phenylmaleimide
  参考文献:China]
  
  108-31-6 = 941-69-5
  反应条件:1.1 Reagents: P-Toluenesulfonic Acid,Copper Sulfate Solvents: Dimethylformamide,Toluene
  标题:Preparation Of N-Substituted Maleimides.
  参考文献:Japan]
  
  108-31-6 = 941-69-5
  反应条件:1.1 Solvents: 1-Butyl-3-Methylimidazolium Hexafluorophosphate; 20 Min,140 °C
  标题:Organic Reactions In Ionic Liquids: Ionic Liquid-Promoted Efficient Synthesis Of N-Alkyl And N-Arylimides
  作者:Le,Zhang-Gao; Chen,Zhen-Chu; Hu,Yi; Zheng,Qin-Guo
  参考文献:Synthesis 日期:2004 卷标:(7) 页码:995-998]
  
  555-59-9 = 941-69-5
  反应条件:1.1 Reagents: Methanol Solvents: Methyl Isobutyl Ketone; 50 Min,20 °C1.2 40 Min,60 °C
  标题:Preparation Of N-Substituted Maleimide In Microchannel Continuous Flow Reactor
  参考文献:China]
  
  108-31-6 = 941-69-5
  反应条件:1.1 Solvents: Xylene; Rt -> 80 °C; 0.5 H,80 °C; 1 H,80 °C1.2 Reagents: Hydroquinone Catalysts: Phosphoric Acid Solvents: Xylene,Water; Rt -> 65 °C; 1.5 H,65 °C
  标题:Synthesis Of N-Phenylmaleimide By Decompressed Azeotropic Method
  作者:Wang,Dong-Hui; Feng,Ya-Qing; Liang,Zu-Pei; Shi,Da-Xin
  参考文献:Huaxue Gongye Yu Gongcheng (Tianjin 日期:2005 卷标:22(6) 页码:427-429]
  
  108-31-6 = 941-69-5
  反应条件:1.1 Catalysts: P-Toluenesulfonic Acid,2,5-Dimethylbenzenesulfonic Acid Solvents: Benzene,Tetrahydrofuran; Rt -> 85 °C; 85 °C -> Reflux; Reflux; 60 Min,Reflux
  标题:One-Step Synthesis Of N-Phenyl Maleimide
  参考文献:China]
  
  108-31-6 = 941-69-5
  反应条件:1.1 Catalysts: Silica,Phosphoric Acid Solvents: Xylene1.2 Catalysts: Triethylamine,Zinc Acetate,2,4-Dimethyl-6-Tert-Butylphenol; Neutralized1.3 5 Min1.4 5 Min; 140 °C; 6 H,140 °C
  标题:Method For The Preparation Of N-Substituted Maleimide
  参考文献:World Intellectual Property Organization]
  
  108-31-6 = 941-69-5
  反应条件:1.1 Reagents: Triethylamine,Silica,Phosphoric Acid Catalysts: Zinc Acetate,2,4-Dimethyl-6-Tert-Butylphenol Solvents: Xylene1.2 5 Min1.3 5 Min; 6 H,140 °C
  标题:Method For Preparing N-Substituted Maleimide
  参考文献:Korea]
  
  555-59-9 = 941-69-5
  反应条件:1.1 Reagents: Acetic Anhydride Catalysts: Sodium Acetate Solvents: Acetic Anhydride; 2 H,Reflux; Cooled1.2 Reagents: Water
  标题:N-Phenyl And N-Phenylalkyl-Maleimides Acting Against Candida Spp.: Time-To-Kill,Stability,Interaction With Maleamic Acids
  作者:Sortino,Maximiliano; Cechinel Filho,Valdir; Correa,Rogerio; Zacchino,Susana
  参考文献:Bioorganic & Medicinal Chemistry 日期:2008 卷标:16(1) 页码:560-568]
  
  108-31-6 = 941-69-5
  反应条件:1.1 Reagents: 1H-Imidazolium,2-Chloro-4,5-Dihydro-1,3-Dimethyl-,Chloride (1:1) Solvents: Toluene
  标题:Preparation Of (Poly)Maleimides As Monomers
  参考文献:Japan]
  
  36342-11-7 = 941-69-5
  反应条件:1.1 Reagents: Triethylamine Solvents: Toluene,Water
  标题:Preparation Of N-Substituted Maleimides With Low Discoloration
  参考文献:Japan]
  
  108-31-6 = 941-69-5
  反应条件:1.1 Reagents: Cupric Acetate,Triphenyl Phosphorotrithioite Solvents: Dimethylformamide,Toluene
  标题:Preparation Of N-Substituted Maleimides
  参考文献:Japan]
  
  108-31-6 = 941-69-5
  反应条件:1.1 Solvents: Acetone; 1 H,Rt; 1 H,40 °C1.2 Reagents: Cobalt Diacetate Catalysts: Triethylamine Solvents: Acetone,Acetic Anhydride; 3 H,40 °C
  标题:Synthesis,Antimicrobial And Corrosion-Inhibiting Activities Of N-Substituted Phenyl Maleimide
  作者:Yang,Fengke; Jiang,Ping
  参考文献:Qingdao Keji Daxue Xuebao 日期:2011 卷标:32(1) 页码:30-33]
  
  108-31-6 = 941-69-5
  反应条件:1.1 Catalysts: 1-Butyl-3-Methylimidazolium Hexafluorophosphate Solvents: 1-Butyl-3-Methylimidazolium Hexafluorophosphate; 20 Min,110 °C
  标题:Synthesis Of Imide Derivatives
  参考文献:China

海关参考信息

• 2901210000-乙烯
  2901220000-丙烯
  2912110000-甲醛
  2912120000-乙醛
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• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管