CAS: 886371-77-3; 5-Bromo-2-(Trifluoromethoxy)Pyridine

相似化合物

899452-26-7 1086393-00-1 1361880-72-9

上下游产品

5-bromopyridin-2-ol Togni's reagent II Togni's reagent

📜3,3-二甲基-1-(三氟甲基)-1,2-苯并碘氧杂戊环,2-羟基-5-溴吡啶 以 氯仿 作为反应溶剂,化学反应 48.0H,以8%的收率获得产物5-溴-2-三氟甲氧基吡啶
参考文献:通过直接o-Cf3键形成区域选择性合成n-杂芳族三氟甲氧基化合物
标题:通过直接o-Cf3键形成区域选择性合成n-杂芳族三氟甲氧基化合物
摘要:描述了使用羟基化的n-杂环和togni试剂通过位点特异性o-Cf 3键形成来合成邻-N-杂芳族三氟甲氧基衍生物的第一步方法.该方法可以前所未有地合成六到五元的n-杂芳族三氟甲氧基化合物,这些化合物含有一个或两个来自最常用的羟基化n-杂环的杂原子.该方法的显着优势包括其简单,温和的条件,避免了对金属或有毒试剂的需求以及与各种官能团的相容性.此外,该方法特别适合大规模应用.
DOI:10.1002/chem.201505181

专利信息

专利号:US-6576447-B2
优先权日:2000-03-21
标 题:Method for synthesis of nucleic acids
发明人：TONOIKE HIROSHI
权利人:SHIMADZU CORP
摘要:An object of the present invention is to provide a novel method for suppressing the action of nucleic acid synthesis inhibitory substances and thereby amplifying a nucleic acid in a sample efficiently.According to the present invention, in a method for synthesis of nucleic acids to amplify an intended nucleic acid in a sample, the sample is brought in advance into contact with an insoluble polymer of a polyanion, a sulfated polymer or a sulfated polysaccharide, to remove nucleic acid synthesis inhibitory substances.

专利号:US-2010143980-A1
优先权日:2007-02-22
标题:Synthesis of novel xylosides and potential uses thereof
发明人：BALAGURUNATHAN KUBERAN; MANIVANNAN ETHIRAJAN; XYLOPHONE V VICTOR; TRAN VY MY; NGUYEN KHIEM
权利人:BALAGURUNATHAN KUBERAN; MANIVANNAN ETHIRAJAN; XYLOPHONE V VICTOR; TRAN VY MY; NGUYEN KHIEM
摘要:The present invention includes a xyloside for use in inducing synthesis of a glycosaminoglycan in a cell, the xyloside having a chemical structure of one of Formula (1), Formula (2), Formula (3), Formula (4), Formula (5), Formula (6), Formula (7), Formula (8), Formula (9), or Formula (10) as shown herein. Also, the present invention includes a method of making a xyloside for use in inducing synthesis of a glycosaminoglycan in a cell, wherein the method is performed with “Clickâ€? chemistry. Additionally, the present invention includes a method of administering a xyloside so as to induce synthesis of a glycosaminoglycan in a cell.

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-6156547-A
优先权日:1990-04-16
标 题:Apparatus for the synthesis of saccharide compositions
发明人：ROTH STEPHEN
权利人:NEOSE PHARM INC
摘要:This invention relates to an apparatus containing specific binary combinations of glycosyltransferases, for the synthesis of specific saccharide compositions such as, for example, oligosaccharides, polysaccharides, glycolipids, and glycopeptides.

专利号:US-6171614-B1
优先权日:1996-10-15
标 题 :Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
发明人：CHAIKOF ELLIOT L; SUN LIJUN
权利人:UNIV EMORY
摘要:The present invention provides glycophospholipid and peptide-phospholipid conjugates comprising a phospholipid moiety and a saccharide or peptide moiety joined by an ether linkage comprising a secondary or tertiary amine. The conjugate structure of the invention comprises a flexible spacer arm between the phospholipid and saccharide or peptide moieties which, being variable in length, serves to optimize saccharide or peptide bioactivity. This invention further provides a method for the synthesis of such conjugates comprising the step of reductive amination. The method is efficient, economical and provides a high yield of product. Glycophospholipid and peptide-phospholipid conjugates of the invention can be incorporated and, optionally, chemically polymerized in self-assembling systems such as membranes, bilayers, films, liposomes and the like, and find utility diagnostically and therapeutically in medical and immuno-biological applications.

专利号:US-4943630-A
优先权日:1982-10-27
标题 :Method for carrying out the organic synthesis of oligosaccharides containing galactosamine-uronic acid patterns, new oligosaccharides obtained and biological applications thereof
发明人：JACQUINET JEAN-CLAUDE; PETITOU MAURICE; SINAY PIERRE; CHOAY JEAN
权利人:CHOAY SA
摘要:Process for the organic synthesis of oligosaccharides forming or corresponding to fragments of acid mucopolysaccharides wherein two compounds comprised of or terminated respectively by patterns of galactosamine structure and patterns of uronic acid structure. Said patterns are specifically substituted. Said process results in oligosaccharides usable particularly in therapy.