CAS: 82547-58-8; (6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-Thiazol-4-yl)-2-Methoxyiminoacetyl]Amino]-3-[(5-Methyltetrazol-2-yl)Methyl]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid

上下游产品

CAS号82547-81-7 头孢特仑新戊酯

7-氨基头孢烷酸置于sodium Metabisulfite,硫酸,三乙胺体系中,用 甲醇,二氯甲烷 作为反应溶剂,化学反应 3.33H,反应生成 头孢特仑新戊酯
参考文献:一种头孢特仑新戊酯的制备方法
标题:一种头孢特仑新戊酯的制备方法
摘要:本发明涉及一种头孢特仑新戊酯的制备方法,该方法包括如下步骤:以7‑aca及5‑甲基四氮唑为起始原料,在h2So4的作用下,反应生成7‑mtca;氨噻唑酸乙酯氨基保护后,在alme3催化下与7‑mtca反应生成中间体ⅰ;该中间体ⅰ在相转移催化剂及酸吸附剂的作用下与特戊酸碘甲酯进行酯化反应,并脱氨基保护,得目标产品头孢特仑新戊酯.本发明反应条件温和,产品纯度高,收率高,工艺稳定,易于放大,适合于工业化生产.

专利信息

专利号:US-7452990-B2
优先权日:2002-12-26
标题 :Intermediates for synthesis of cephalosporins and process for preparation of such intermediates
发明人：DATTA DEBASHISH; DANTU MURALIKRISHNA; MISHRA BRIJKISHORE; SHARMA POLLEPEDDI LAKSHMI NARAYANA
权利人:LUPIN LTD
摘要:A novel 4-halo-2-oxyimino-3-oxo butyric acid-N,N-dimethyl formiminium chloride chlorosulfate of formula (I) useful in the preparation of cephalosporin antibiotics n nwhereinn n X is chlorine or bromine; R is hydrogen, C 1-4 alkyl group, an easily removable hydroxyl protective group, —CH 2 COOR 5 , or —C(CH 3 ) 2 COOR 5 , wherein R 5 is hydrogen or an easily hydrolysable ester group. The compound of formula (I) is prepared by reacting 4-halo-2-oxyimino-3-oxobutyric acid of formula (IV 1 ), n nwherein X, R and R 5 are as defined above, with N,N-dimethylformiminium chloride chlorosulphate of formula (VII)n n nin an organic solvent at a temperature ranging from −30° C. to −15° C. The cephalosporins that may be prepared from the intermediate include cefdinir, cefditoren pivoxil, cefepime, cefetamet pivoxil, cefixime, cefmenoxime, cefodizime, cefoselis, cefotaxime, cefpirome, cefpodoxime proxetil, cefquinome, ceftazidime, cefteram pivoxil, ceftiofur, ceftizoxime, ceftriaxone and cefuzonam.

专利号:US-2006135761-A1
优先权日:2002-12-26
标 题 :Novel intermediates for synthesis of cephalosporins and process for preparation of such intermediates

专利号:WO-2004058695-A1
优先权日:2002-12-26
标 题 :Novel intermediates for synthesis of cephalosporins and process for preparation of such intermediates

专利号:EP-1575913-A1
优先权日:2002-12-26
标 题:Novel intermediates for synthesis of cephalosporins and process for preparation of such intermediates