CAS: 82419-52-1; 9-Fluoro-3-Methyl-7-Oxo-10-(Piperazin-1-yl)-2,3-Dihydro-7H-[1,4]Oxazino[2,3,4-Ij]Quinoline-6-Carboxylic Acid

该化合物是一个复杂的有机化合物,其独特的双环结构包含一种丙烯和苯氧酸混合物.该化合物的特点是一个碳oxy酸功能组,该组有助于其酸性和潜在的再活动.氟丙胺和氟丙氨环的存在表明,它可能表现出有趣的药理特性,有可能影响其溶性与生物活动.7-氧和3甲基分组进一步改变其化学行为,可能加强它与生物目标的相互作用.这些化合物经常因其在药用化学中的潜在用途,特别是在药品研制中,而受到调查.这种化合物的结构复杂性和功能组还可能导致多种化学再活动,使其成为合成有机化学化学和药物设计的兴趣对象.

结构式图片

物理性质

MSDS等安全信息

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上下游产品

CAS号110-85-0 哌嗪 | CAS号82419-35-0 氟嗪羧酸 | CAS号771-69-7 2,3,4-三氟硝基苯 | CAS号82419-32-7 2-丙酮氧基-3,4-二氟硝基苯 | CAS号82419-26-9 2,3-二氟-6-硝基苯酚 | CAS号82419-34-9 氧佛沙星酯 | CAS号82419-33-8 7,8-二氟-2,3-二氢-3... | CAS号86760-99-8 diethyl [(-)-7,...

合成工艺路线路线简述

  • 82419-35-0 = 82419-52-1
    反应条件:1.1 Catalysts: Molybdate(42-),Triacontakis[μ-(Acetato-Ko:Ko′)]Doheptacontaaquaoctacontahecta-μ... Solvents: Water; 27 Min,Reflux
    标题:Fast And Green Method To Synthesis Of Quinolone Carboxylic Acid Derivatives Using Giant-Ball Nanoporous Isopolyoxomolybdate As Highly Efficient Recyclable Catalyst In Refluxing Water
    作者:Mirzaie,Yahya; Et Al
    参考文献:Journal Of The Mexican Chemical Society 日期:2017 卷标:61(1) 页码:35-40]

    82419-26-9 = 82419-52-1
    反应条件:1.1 Reagents: Potassium Iodide Catalysts: Potassium Carbonate2.1 Solvents: Ethanol3.1 -4.1 Reagents: Hydrochloric Acid Catalysts: Acetic Acid5.1 Solvents: Dimethyl Sulfoxide
    标题:Synthesis And Antibacterial Activities Of Substituted 7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-De][1,4]Benzoxazine-6-Carboxylic Acids
    作者:Hayakawa,Isao; Et Al
    参考文献:Chemical & Pharmaceutical Bulletin 日期:1984 卷标:32(12) 页码:4907-13]

    82419-35-0 = 82419-52-1
    反应条件:1.1 Catalysts: Zirconium Dioxide (Sulfonic Acid Derivative Absorbed On Ferrite) Solvents: Water; 27 Min,Reflux
    标题:Nano-Fe3O4@zro2-So3H As Highly Efficient Recyclable Catalyst For The Green Synthesis Of Fluoroquinolones
    作者:Nakhaei,Ahmad; Et Al
    参考文献:Letters In Organic Chemistry 日期:2018 卷标:15(9) 页码:739-746]

    82419-35-0 = 82419-52-1
    反应条件:1.1 Solvents: Dimethyl Sulfoxide; 12 H,95 °C1.2 Reagents: Acetone; Cooled
    标题:Synthesis And Biological Properties Of Conjugates Between Fluoroquinolones And A N3''-Functionalized Pyochelin
    作者:Noel,Sabrina; Et Al
    参考文献:Organic & Biomolecular Chemistry 日期:2011 卷标:9(24) 页码:8288-8300]

    82419-35-0 = 82419-52-1
    反应条件:1.1 Solvents: Dimethyl Sulfoxide; 12 H,95 °C1.2 Reagents: Acetone; Cooled
    标题:Synthesis And Biological Properties Of Conjugates Between Fluoroquinolones And A N3''-Functionalized Pyochelin
    作者:Noel,Sabrina; Et Al
    参考文献:Organic & Biomolecular Chemistry 日期:2011 卷标:9(24) 页码:8288-8300]

    82419-35-0 = 82419-52-1
    反应条件:1.1 Catalysts: Molybdate(42-),Triacontakis[μ-(Acetato-Ko:Ko′)]Doheptacontaaquaoctacontahecta-μ... Solvents: Water; 27 Min,Reflux
    标题:Fast And Green Method To Synthesis Of Quinolone Carboxylic Acid Derivatives Using Giant-Ball Nanoporous Isopolyoxomolybdate As Highly Efficient Recyclable Catalyst In Refluxing Water
    作者:Mirzaie,Yahya; Et Al
    参考文献:Journal Of The Mexican Chemical Society 日期:2017 卷标:61(1) 页码:35-40]

    82419-34-9 = 82419-52-1
    反应条件:1.1 Reagents: Hydrochloric Acid Catalysts: Acetic Acid2.1 Solvents: Dimethyl Sulfoxide
    标题:Synthesis And Antibacterial Activities Of Substituted 7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-De][1,4]Benzoxazine-6-Carboxylic Acids
    作者:Hayakawa,Isao; Et Al
    参考文献:Chemical & Pharmaceutical Bulletin 日期:1984 卷标:32(12) 页码:4907-13]

    40516-46-9 = 82419-52-1
    反应条件:1.1 -2.1 Reagents: Hydrochloric Acid Catalysts: Acetic Acid3.1 Solvents: Dimethyl Sulfoxide
    标题:Synthesis And Antibacterial Activities Of Substituted 7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-De][1,4]Benzoxazine-6-Carboxylic Acids
    作者:Hayakawa,Isao; Et Al
    参考文献:Chemical & Pharmaceutical Bulletin 日期:1984 卷标:32(12) 页码:4907-13]

    82419-32-7 = 82419-52-1
    反应条件:1.1 Solvents: Ethanol2.1 -3.1 Reagents: Hydrochloric Acid Catalysts: Acetic Acid4.1 Solvents: Dimethyl Sulfoxide
    标题:Synthesis And Antibacterial Activities Of Substituted 7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-De][1,4]Benzoxazine-6-Carboxylic Acids
    作者:Hayakawa,Isao; Et Al
    参考文献:Chemical & Pharmaceutical Bulletin 日期:1984 卷标:32(12) 页码:4907-13]

    82419-32-7 = 82419-52-1
    反应条件:1.1 Solvents: Ethanol2.1 -3.1 Reagents: Hydrochloric Acid Catalysts: Acetic Acid4.1 Solvents: Dimethyl Sulfoxide
    标题:Synthesis And Antibacterial Activities Of Substituted 7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-De][1,4]Benzoxazine-6-Carboxylic Acids
    作者:Hayakawa,Isao; Et Al
    参考文献:Chemical & Pharmaceutical Bulletin 日期:1984 卷标:32(12) 页码:4907-13
📜2-丙酮氧基-3,4-二氟硝基苯置于盐酸,氢气,镍体系中,用 乙醇,溶剂黄146,二甲基亚砜 作为反应溶剂,化学反应 8.0H,反应生成 氧氟沙星相关物质a
参考文献:Synthesis And Antibacterial Activities Of Substituted 7-Oxo-2,3-Dihydro-7H-Pyrido(1,2,3-De)(1,4)Benzoxazine-6-Carboxylic Acids.
标题:Synthesis And Antibacterial Activities Of Substituted 7-Oxo-2,3-Dihydro-7H-Pyrido(1,2,3-De)(1,4)Benzoxazine-6-Carboxylic Acids.
摘要:作为寻找新的合成抗菌剂以对抗全身感染的一部分,合成了多种7-氧代-2,3-二氢-7H-吡啶并[1,2,3-De][1,4]苯并噁嗪-6-羧酸类似物.在合成的新化合物中,9-氟-3-甲基-10-(4-甲基-1-哌嗪基)-7-氧代-2,3-二氢-7H-吡啶并[1,2,3-De][1,4]苯并噁嗪-6-羧酸(dl-8280)显示出对革兰氏阳性和阴性病原体,包括铜绿假单胞菌的强效抗菌活性,并且其代谢情况在单独的实验中显示为有利.
DOI:10.1248/cpb.32.4907

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参考文献:10.1016/j.ejmech.2020.112967
摘要:Girase PS, Dhawan S, Kumar V, Shinde SR, Palkar MB, Karpoormath R. An appraisal of anti-mycobacterial activity with structure-activity relationship of piperazine and its analogues: A review. European Journal of Medicinal Chemistry. 2021 Jan;210():112967. doi: 10.1016/j.ejmech.2020.112967.
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