CAS: 6367-98-2; H-Cys(2-Hydroxyethyl)-Oh

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📜Methyl (2R)-N-Carbobenzyloxy-β-Hydroxyethylcysteineate置于硫酸体系中,化学反应 4.0H,以45%的收率获得产物s-2-羟乙基-L-半胱氨酸
参考文献:Stereochemistry Of Reactions Of The Inhibitor/substrates L-And D-β-Chloroalanine With β-Mercaptoethanol Catalysed By L-Aspartate Aminotransferase And D-Amino Acid Aminotransferase Respectively
标题:Stereochemistry Of Reactions Of The Inhibitor/substrates L-And D-β-Chloroalanine With β-Mercaptoethanol Catalysed By L-Aspartate Aminotransferase And D-Amino Acid Aminotransferase Respectively
摘要:两种α家族的plp依赖性酶,L-天冬氨酸氨基转移酶和d-氨基酸氨基转移酶,已被证明分别能催化l-和d-β-氯丙氨酸与β-巯基乙醇的β取代反应,这些反应是β家族plp依赖性酶的典型特征.已显示l-天冬氨酸氨基转移酶催化的反应发生时保持立体化学,这是β家族酶催化反应的典型结果.还有迹象表明,D-氨基酸氨基转移酶催化的反应也可能涉及立体化学的保持.当适当的β-氯丙氨酸的对映体作为底物时,这两种酶已被证明能在c-3位催化交换反应.
DOI:10.1039/b508199H

专利信息

专利号:WO-2023242133-A1
优先权日:2022-06-16
标 题:Hair repigmenting composition
发明人：BORDIGNON MATTEO; HERNÃ?NDEZ NAVARRO SERGIO; SEGURA TEJEDOR JORDI
权利人:BELLA AURORA LABS S A; BORDIGNON MATTEO
摘要:The present invention refers to the cosmetic use of a MIA (melanoma inhibitory activity) protein inhibitor peptide as hair repigmenting agent. It refers also to a method for hair repigmenting using a MIA peptide inhibitor. Said peptide shows an increase of the expression of IRF4 gene, and that the combination of said peptide and commercially available peptide derivatives shows a synergistic effect on the expression of IRF4 and/or TYR genes. IRF4 gene is a biomarker associated with hair greying and TYR gene is a key enzyme in melanin synthesis.

专利号:US-6416988-B1
优先权日:1998-12-10
标题:Beta-1,3-galactosyltransferase homologs
发明人：CONKLIN DARRELL C; YAMAMOTO GAYLE; JASPERS STEPHEN R; GAO ZEREN
权利人:ZYMOGENETICS INC
摘要:The present invention relates to polynucleotide and polypeptide molecules for znssp2, a novel member of the galactosyltransferase family. The polypeptides, and polynucleotides encoding them, are cell-cell interaction and glycoprotein synthesis modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the znssp2 polypeptides.

专利号:US-6361985-B1
优先权日:1999-01-12
标题:Beta-1,3-galactosyltransferase homolog, ZNSSP6
发明人：CONKLIN DARRELL C; YAMAMOTO GAYLE; GAO ZEREN; JASPERS STEPHEN R
权利人:ZYMOGENETICS INC
摘要:The present invention relates to polynucleotide and polypeptide molecules for znssp6, a novel member of the galactosyltransferase family. The polypeptides, and polynucleotides encoding them, are cell-cell interaction and glycoprotein synthesis modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the znssp6 polypeptides.