CAS: 55812-90-3; Dexamethasone Acetate

该化合物是其复杂的类固醇结构,其中包括氟原子和多氢氧基组,有助于其生物活动.该化合物通常用于其防炎和免疫抑制特性,因此在治疗过敏,哮喘和自动免疫紊乱等各种条件方面很有价值.乙基氧组的存在增强了其溶性与生物利用率,而特定立体化学化学化学组在11和16个位置上对于其与甘醇类受体的相互作用至关重要.作为水合体,该化合物形成稳定的晶体结构,能够影响其药理学.

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      专利号:US-2024409557-A1
      优先权日:2023-05-09
      标 题 :5,6-fused and 6,6-fused bicyclic alcohols and ethers and compositions for use as 15-prostaglandin dehydrogenase modulators
      发明人：GREENMAN KEVIN LLOYD; PICKRELL ALEXANDER J; LI KEXUE; AMEGADZIE ALBERT K; WANG HUI-LING; WEIRES NICHOLAS ANTHONY; ALLEN JOHN G; BOURBEAU MATTHEW P
      权利人:AMGEN INC
      摘要:The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a general Formula (A).Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (A).

      专利号:KR-20160017105-A
      优先权日:2008-01-15
      标题:Synthesis of resorcylic acid lactones useful as therapeutic agents

      专利号:JP-6159350-B2
      优先权日:2008-01-15
      标 题:Synthesis of resorcinic acid lactones useful as therapeutic agents

      专利号:KR-20160112016-A
      优先权日:2008-01-15
      标题:Synthesis of resorcylic acid lactones useful as therapeutic agents

      专利号:US-10501496-B2
      优先权日:2013-05-23
      标 题 :Chemical synthesis and screening of bicyclic peptide libraries

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      摘要:Compound: Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-, hydrate (2:3), (11β,16α)-
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