CAS: 54997-90-9; 4-Isopropylbenzenesulfonyl Chloride

该化合物是一种有机化合物,其特征是附于一个苯环上的全氟化碳功能组,该环具有异丙基替代体,其位置为para .该化合物一般是无色的,根据纯度和温度而呈现为黄色的黄色液体或固态;以其反应性而闻名,特别是在核生殖替代反应中,该物质组可被各种核素取代,使其在有机合成中有用.该化合物在二氯甲烷和乙醚等有机溶剂中溶解,但由于其水脱氧芳香结构,一般在水中不溶解.在处理该物质时,必须采取安全防范措施,因为它可能具有腐蚀性,并可能对皮肤,眼睛和呼吸系统造成刺激.建议将该物质适当储存在远离湿气的冷干地方,以便保持其稳定性和再活性.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

Isopropylbenzene p-cumenesulfonic acid 4-mercapto-cumene 4-isopropylbenzenesulfonyl hydrazide 3-(4-Isopropyl-benzolsulfonylamino)-propionsaeurenitril 4-mercapto-cumene N-(5-cyclohexyl-[1,3,4]oxadiazol-2-yl)-4-isopropyl-benzenesulfonamideN-(5-cyclohexyl-[1,3,4]oxadiazol-2-yl)-4-isopropyl-benzenesulfonamide threonineN-(4-isopropylphenyl)sulfonylthreonine

合成工艺路线路线简述

  • 合成目标产物 4-Isopropylbenzenesulfonyl Chloride 主要起始原料 Cumene
  • (文献来源)合成步骤主要原料 Cumene
异丙苯置于氯磺酸体系中,化学反应生成 对-异丙基苯磺酰氯
参考文献:氧化还原聚合物:Ii. 氧化还原均聚物及其单体模型的标准氧化电位
标题:氧化还原聚合物:Ii. 氧化还原均聚物及其单体模型的标准氧化电位
摘要:制备了一种新的单体 2,5-双-(2-四氢吡喃氧基)-4-甲基-4'-乙烯基二苯砜.使用连续和不连续滴定技术测量了源自该单体和先前报道的一种 (1) 及其中间体和模型化合物的两种线性氧化还原均聚物的标准氧化电位.
DOI:10.1139/v63-067

海关参考信息

专利信息


专利号:US-5688974-A
优先权日:1995-12-12
标 题 :Process for the preparation of an endothelin antagonist
发明人:DEVINE PAUL N; TSCHAEN DAVID M
权利人:MERCK & CO INC
摘要:The instant invention relates to a process for the stereoselective synthesis of a compounds of formula I: ##STR1##

专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人:LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC

专利号:US-2020149034-A1
优先权日:2017-03-17
标题:Methods and Compositions for Synthesis of Encoded Libraries

专利号:US-6858309-B2
优先权日:2001-03-28
标 题:Methods of polymerization
发明人:KAMBOURIS PETER; WHITTAKER MICHAEL; DAVIS TOM; BLAKEY IDRISS; DAY GARY M
权利人:POLYMERAT PTY LTD
摘要:The present invention provides improved methods for conducting living/controlled polymerization on polymeric solid supports. The improved methods allow polymerization to occur directly from the non-functionalized surface of a bulk support. In addition, polymerization may be re-initiated to provide co-polymers. The disclosed methods may employ the non-nitroxide-based RAFT and ATRP control agents that allow controlled polymerization to proceed at relatively low temperatures (<80° C.). Furthermore, these improved methods may provide graft polymers with decreased levels of “in-growthâ€? of the bulk solid support. The invention also provides substrate polymers, with improved properties for solid phase synthesis and diagnostic applications, which may be made by the disclosed methods.

专利号:US-2004076623-A1
优先权日:2000-07-14
标题:Activated modular grafted polymeric surfaces
发明人:EDE NICHOLAS JON; ERCOLE FRANCESCA; TRIBBICK GORDON; SANDAYAKE SAMAN; PERERA SENAKE
摘要:The present invention relates generally to new surfaces for solid phase chemistry applications, more specifically plastics surfaces modified by graft polymerisation for use in chemical synthesis and/or immobilisation of chemical entities and/or compounds. n In particular the invention relates to an activated modular grafted polymeric surface, which is suitable for use as a reagent for solid phase organic synthesis, or as a reagent for the affinity capture, presentation or preparation of biomolecules such as proteins, oligonucleotides, nucleic acids, peptides, and lectins. The grafted polymeric surfaces of the invention are particularly useful as scavenger reagents in combinatorial synthetic protocols, and as affinity reagents in protein purification and proteomics.

专利号:US-2008194629-A1
优先权日:2005-05-03
标题 :3-Mono-and 3,5-Disubstituted Piperidine Derivatives as Renin Inhibitors
发明人:BAESCHLIN DANIEL KASPAR; BREITENSTEIN WERNER; EHRHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; RUDISSER SIMON; VANGREVELINGHE ERIC; IRIE OSAMU; UMEMURA ICHIRO; SUZUKI MASAKI; MOGI MUNETO; KANAZAWA TAKANORI; YOKOKAWA FUMIAKI; NIHONYANAGI ATSUKO
权利人:BAESCHLIN DANIEL KASPAR; BREITENSTEIN WERNER; EHRHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; RUDISSER SIMON; VANGREVELINGHE ERIC; IRIE OSAMU; UMEMURA ICHIRO; SUZUKI MASAKI; MOGI MUNETO; KANAZAWA TAKANORI; YOKOKAWA FUMIAKI; NIHONYANAGI ATSUKO
摘要:The invention relates to 3,5-piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-piperidine compound, and/or a method of treatment comprising administering a 3,5-piperidine compound, a method for the manufacture of a 3,5-piperidine compound, and novel intermediates and partial steps for their synthesis. Especially, the 3,5-piperidine compounds have the formula I, wherein the symbols have the meanings described in the specification.
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对异丙基苯磺酰氯
4-Isopropylbenzenesulfonyl chloride
产品图片纯度:98
250kg/drum
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合成参考文献


摘要:Shcherbakova, I., Science of Synthesis, (2007) 31, 789.
摘要:Merino, P., Science of Synthesis, (2010) 45, 35.
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