CAS: 530-56-3; 4-Hydroxy-3,5-Dimethoxybenzyl Alcohol

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📜丁香醛置于sodium Tetrahydroborate体系中,用 四氢呋喃,甲醇,水 作为反应溶剂,以81 %的收率获得产物2,6-二甲氧基酚
参考文献:Akt/mtor Targeting Activity Of Resveratrol Derivatives In Non-Small Lung Cancer
标题:Akt/mtor Targeting Activity Of Resveratrol Derivatives In Non-Small Lung Cancer
摘要:Akt-Mtor信号通路对于癌细胞的生存和增殖至关重要,已成为一种有趣的药物靶点.本研究评估了五种白藜芦醇衍生物在非小细胞肺癌细胞系中的抗癌活性和对akt/mtor靶向作用的影响.通过2,5-二苯基-2H-四唑溴化物(mtt)试验,核染色和集落形成试验评估了白藜芦醇衍生物对细胞增殖的影响.此外,通过免疫荧光和western Blotting分析白藜芦醇衍生物对增殖相关蛋白表达的影响.结果显示,白藜芦醇的两种衍生物rd2和rd3结构非常相似,但表现出不同的细胞毒性.在a549细胞系中,Rd2和rd3的ic50分别为108.6+/-10.82和大于200 µm,在h23细胞中,Rd2和rd3的ic50分别为103.5+/-6.08和大于200 µm.与对照组相比,Rd2抑制了细胞增殖并诱导了凋亡,而rd3的影响很小.rd2处理的细胞伴随着细胞内p-Akt和p-Mtor的降低而出现凋亡核.而rd3对这些蛋白的影响很小.分子对接分析表明,Rd2与akt分子在atp结合和变构位点上具有高亲和力的相互作用,表明rd2是一种潜在的akt抑制剂.本研究为通过akt/mtor抑制剂治疗肺癌提供了有用的信息,特别是白藜芦醇衍生物rd2.
DOI:10.3390/molecules27238268

专利信息

专利号:US-7056348-B2
优先权日:2001-04-19
标题:5-aryl-1,3,3-trimethyl-2-methylene-indoline derivatives and salts thereof, methods for the production and use of said compounds for the temporary coloration of fibers
发明人：SAUTER GUIDO; BRAUN HANS-JUERGEN; REICHLIN NADIA
权利人:WELLA AG
摘要:A method for the synthesis of 5-aryl-1,3,3,-trimethyl-2-methylene-indoline derivatives of Formula (I) or its salts of Formula (Ia) wherein 1 mole of a 5-aryl-2,3,3-trimethyl-3H-indole derivative of Formula (VII) is reacted for 1 to 44 hours at a temperature of 20° to 180° C. in an apolar, aprotic or polar, protic or polar aprotic solvent with 1 to 50 moles of a compound of Formula R1-A; new compounds of Formulas (I)/(Ia) and (V), obtainable by this method as well as an agent containing at least one compound of Formula (I)/(Ia) and a carbonyl/imine compound for dyeing keratinic fibers and a method for temporarily dyeing keratin fibers, for which the keratin fiber is dyed with the aforementioned agent and the dyeing, so obtained, is removed again at any later time by a sulfite preparation.

专利号:CN-108440355-A
优先权日:2018-03-16
标题:A kind of sulfide compound and its synthesis method and application