CAS: 51059-44-0; (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-((5-Hydroxy-8-Methoxy-4-Oxo-2-Phenyl-4H-Chromen-7-yl)Oxy)Tetrahydro-2H-Pyran-2-Carboxylic Acid

上下游产品

CAS号632-85-9 汉黄芩素 | CAS号2616-64-0 UDP葡萄糖醛酸 | CAS号632-85-9 汉黄芩素

Wogonin 7-O-β-D-Ethylglucuronide置于sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应生成 汉黄芩苷
参考文献:Flavonoids From Roots Of Scutellaria Intermedia
标题:Flavonoids From Roots Of Scutellaria Intermedia
摘要:
DOI:10.1007/s10600-018-2412-1

专利信息

专利号:US-8377895-B2
优先权日:2008-07-10
标 题 :Cyclin-dependent protein kinases inhibitors of Scutellaria flavonoid organic amine derivatives, synthesis and use thereof
发明人：ZHANG SHIXUAN; BAO YONGMING; SUN YUMING; LI KANGJIAN; ZOU LIANG; MA JIGANG; SUN XIAODAN; SHANG HAIYAN; LI JING
权利人:ZHANG SHIXUAN; BAO YONGMING; SUN YUMING; LI KANGJIAN; ZOU LIANG; MA JIGANG; SUN XIAODAN; SHANG HAIYAN; LI JING
摘要:The present invention provides a series of cyclin-dependent protein kinases (Cdks) inhibitors, Scutellaria flavonoid organic amine derivatives, synthesis and use thereof. The preparation method is as follows: taking Baicalein (or Wogonin) from Scutellaria baicalensis as lead compound, mixting it with formaldehyde solution and organic amine compounds based on the molar ratio of 1:1-1.2:1-1.2, adding methanol of duplicate weight than baicalein and reacting at 50-70° C., filtering the sediment and washing and then drying so as to get the product with a content of not less than 97% (weight). Similar to Flavopiridol and P276-00, the activity of baicalein organic amine derivatives inhibiting Cdks has an increase of 50 times compared with that of Baicalin. It can selectively induce apoptosis of the proliferative phase cancer cells, which has scarcely any influence to the normal structure, and it belongs to anticancer drugs of cell cycle inhibitor kind. The product has a rich source of raw materials and has simple process, high purity, low cost, clear metabolic mechanism, high efficiency and low toxicity, which can be made into oral preparations or injections together with acid salts and is expected to become high efficient and low toxicity anti-cancer and AIDS drugs.

专利号:CN-113046333-A
优先权日:2019-12-26
标题:Flavonoid-8-hydroxylase and its application in the synthesis of 8-hydroxyflavonoids

专利号:US-2006165821-A1
优先权日:2002-12-27
标 题 :Composition comprising scutellaria baicalensis and their uses thereof
发明人：ZHANG YONG; YE FEI; LI FAN
权利人:ZHANG YONG; YE FEI; LI FAN
摘要:This invention described various formula composite of Scutellaria baicalensis for various diseases and conditions. The formula takes the advantage of our recent discovery of Scutellaria baicalensis can inhibit cyclooxygenase-2 (COX-2) activity and expression, resulting in decrease of prostaglandin synthesis. COX-2 is involved in many biological processes, such as inflammation, pain, carcinogenesis, etc. Combination of Scutellaria baicalensis with lycopene can be used for cancer prevention, especially smoking induced. Combination of Scutellaria baicalensis with glucosamine and chondroitin can be used for arthritis. Finally, this invention disclosed various method to prepare this formula and composition.

专利号:US-2010197619-A1
优先权日:2008-07-10
标 题 :Cyclin-dependent protein kinases inhibitors of scutellaria flavonoid organic amine derivatives, synthesis and use thereof