CAS: 35179-98-7; Chloromethyl Ethyl Carbonate

相似化合物

35273-90-6 50893-36-2 35180-01-9

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CAS号64-17-5 乙醇 | CAS号22128-62-7 氯甲酸氯甲酯

氯甲酸氯甲酯置于n,N-二异丙基乙胺体系中,用 乙醇,二氯甲烷 用作溶剂,化学反应生成氯甲基乙基碳酸酯
参考文献:Compositions And Methods For Enhanced Drug Delivery
标题:Compositions And Methods For Enhanced Drug Delivery
摘要:本发明涉及将药物制剂传递到患者的膜层,包括皮肤层或黏膜膜层的方法.药物制剂与化学修饰剂通过生理可切割键共价结合,从而增强了药物的膜传输和传递.

专利信息

专利号:US-9359376-B2
优先权日:2011-04-08
标题:Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds
发明人：DUGAR SUNDEEP; MAHAJAN DINESH; HOLLINGER FRANK PETER
权利人:DUGAR SUNDEEP; MAHAJAN DINESH; HOLLINGER FRANK PETER; SPHAERA PHARMA PTE LTD
摘要:The present invention relates to the synthesis and application of novel chiral/achiral substituted methyl formyl reagents to modify pharmaceutical agents and/or biologically active substances to modify the physicochemical, biological and/or pharmacokinetic properties of the resulting compounds from the unmodified original agent.

专利号:US-2012071640-A1
优先权日:2008-12-23
标题 :Sulfurizing reagents and their use for oligonucleotides synthesis
发明人：MAZUR WIESLAW ADAM; HE YIGANG; SOROKIN VICTOR D
权利人:MAZUR WIESLAW ADAM; HE YIGANG; SOROKIN VICTOR D; GIRINDUS AMERICA INC
摘要:An oligonucleotide which comprises at least one internucleotide linkage comprising a P—S—R bond and at least two nucleosides, wherein R corresponds to the formula (I) n n n n n n n n n n wherein A is a geminally substituted alkylene group, preferably CH 2 , X and Y are independently selected from S and O, and R 0 is selected from the group consisting of optionally substituted carbon bonded organic residue, such as in particular optionally substituted alkyl or aryl, SRx, ORx and NRxRy wherein Rx and/or Ry are selected from H and organic residues and at least Rx is a substituent other than H. Another object of the invention is a sulfurizing agent useful for oligonucleotide manufacture and the manufacture thereof. Other nucleotides described comprise at least one internucleotide linkage comprising a P—S—R bond, at least one internucleotide linkage comprising a P—S—R′ bond and at least three nucleosides wherein R′ is an organic residue other than the group R, preferably selected from a group consisting of an aryl group and a heteroaryl group which is bonded to the S-atom through an annular carbon atom.

专利号:US-5827855-A
优先权日:1992-12-28
标题 :Hexahydronaphthalene ester derivatives their preparation and their therapeutic uses
发明人：KOGEN HIROSHI; ISHIHARA SADAO; KOGA TEIICHIRO; KITAZAWA EIICHI; SERIZAWA NOBUFUSA; HAMANO KIYOSHI
权利人:SANKYO CO
摘要:Compounds of formula (I): (I) wherein R1 represents a group of formula (II) or (III): (II) (III) R2 is alkyl, alkenyl or alkynyl; R3 and R4 are each hydrogen, alkyl, alkenyl or alkynyl; R5 is hydrogen or a carboxy-protecting group; Ra is a group of formula -OR6; R6 is hydrogen; R6a and R6b are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulfonyl, halogenated alkanesulfonyl or arysulfonyl, and their salts and esters. Such compounds inhibit the synthesis of cholesterol, and can be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.

专利号:US-2014179875-A1
优先权日:2011-07-29
标题:Sulfurization reagents on solid supports
发明人：MAZUR WIESLAW ADAM; SOROKIN VICTOR; LAUGHLIN STEVEN KARL
权利人:MAZUR WIESLAW ADAM; SOROKIN VICTOR; LAUGHLIN STEVEN KARL; GIRINDUS AMERICA INC
摘要:Described herein are novel solid-supported sulfurization reagents having the general structure: (I) wherein (P) is a polymer; X is a linker; R 1 is an alkyl group, a cycloalkyl group, an aryl group, or a heterocycle; and R 2 is an alkyl group, an aryl group, a methyleneacyloxy group having the formula —CH 2 —O—C(O)—R 7 , a methylene carbonate group having the formula —CH 2 —O—C(O)—OR 8 , or a methylene carbamate group having the formula —CH 2 —O—C(O)—NR 9 R 10 , wherein R 7 is a C 1 to C 20 hydrocarbon residue, R 8 is any alkyl, cycloalkyl, aryl, or heteroaryl, and R 9 and R 10 are independently hydrogen, alkyl, cycloalkyl, aryl, or heteroaryl. Other embodiments include solid-supported sulfurization reagents having the structure of Formula I, wherein (P) is a polystyrene-based solid support and X is an aromatic linker. Also described herein are methods for synthesizing the solid-supported sulfurization reagents and their use during the synthesis of oligonucleotides.

专利号:US-5491167-A
优先权日:1993-01-29
标题 :Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses
发明人：ISHIHARA SADAO; KOGEN HIROSHI; KOGA TEIICHIRO; KITAZAWA EIICHI; SERIZAWA NOBUFUSA
权利人:SANKYO CO
摘要:Compounds of formula (I): ##STR1## and their salts and esters have the ability to inhibit the synthesis of cholesterol, and can thus be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.

专利号:WO-2010072831-A1
优先权日:2008-12-23
标题 :Sulfurizing reagents and their use for oligonucleotides synthesis
发明人：MAZUR WIESLAW ADAM; HE YIGANG; SOROKIN VICTOR
权利人:GIRINDUS AMERICA INC; MAZUR WIESLAW ADAM; HE YIGANG; SOROKIN VICTOR; GIRINDUS AG
摘要:An oligonucleotide which comprises at least one internucleotide linkage comprising a P-S-R bond and at least two nucleosides, wherein R corresponds to the formula (I) wherein A is a geminally substituted alkylene group, preferably CH 2 , X and Y are independently selected from S and O, and R 0 is selected from the group consisting of optionally substituted carbon bonded organic residue, such as in particular optionally substituted alkyl or aryl, SRx, ORx and NRxRy wherein Rx and/or Ry are selected from H and organic residues and at least Rx is a substituent other than H. Another object of the invention is a sulfurizing agent useful for oligonucleotide manufacture and the manufacture thereof.