专利号:US-6156922-A 优先权日:1995-12-28 标题 :Method for the synthesis of an aromatic derivative ortho-disubstituted by a halogen atom other than fluorine and by a cyano group 发明人:RUSSELL JAMES; GILBERT LAURENT; MAESTRO JEAN PIERRE 权利人:RHODIA CHIMIE SA 摘要:PCT No. PCT/FR96/02100 Sec. 371 Date Sep. 15, 1998 Sec. 102(e) Date Sep. 15, 1998 PCT Filed Dec. 27, 1996 PCT Pub. No. WO97/24318 PCT Pub. Date Jul. 10, 1997The present invention relates to a method for the synthesis of a halogen substituted aryl nitrile, where the halogens are selected from Cl, Br, or I, by reacting an aryl dihalide with a halogen/fluoride exchange reactant to produce a halogen substituted aryl fluoride which is then reacted with a fluoride/cyanide exchange reactant to produce the halogen substituted aryl nitrile.
专利号:US-4450308-A 优先权日:1980-02-08 标 题:Process for the preparation of trifluoromethylphenyl oxyphenyl ether compounds 发明人:FOERSTER HEINZ; PRIESNITZ UWE 权利人:BAYER AG 摘要:New process for the preparation of known trifluoromethylphenyl oxyphenyl ether compounds of the formula ##STR1## wherein X stands for fluorine, chlorine or bromine and n R for moieties, substituted if desired, of the series alkyl, alkenyl and alkinyl, n by reacting 1,2-dihalogen-4-trifluoromethylbenzenes of the formula ##STR2## in which X and X 1 independently of one another stand for fluorine, chlorine or bromine, n with phenols of the formula ##STR3## in which R has the meaning given above, and basic alkali or alkaline earth compounds or with the salts formed from the phenols of formula (III) and the basic alkali or alkaline earth compounds, in the presence of diluents at temperatures between 60° and 120° C. n The compounds of the formula (I) are intermediates for the synthesis of herbicides.
专利号:US-8507693-B2 优先权日:2010-03-03 标 题:Process for synthesis of fipronil 发明人:GHARDA KEKI HORMUSJI 权利人:GHARDA KEKI HORMUSJI 摘要:The present disclosure relates to a process for trifluoromethylsulfinyl pyrazole compound of formula I, n nfrom a compound of formula III, wherein, R, R 1 and R 2 represent a group containing halogen group respectively and R 3 represents a perhaloalkyl.
专利号:US-4621160-A 优先权日:1983-06-23 标题 :Process for the chlorination of aromatic derivatives 发明人:DESBOIS MICHEL; DISDIER CAMILLE 权利人:RHONE POULENC SPEC CHIM 摘要:A process for the chlorination of aromatic derivatives. The aromatic derivative is reacted with chlorine gas in liquid hydrofluoric acid. The products obtained are useful as intermediates for the synthesis of compounds having a plant-protecting or pharmaceutical activity.
专利号:US-4575571-A 优先权日:1983-06-23 标题:Process for the simultaneous halogenation and fluorination of aromatic derivatives 发明人:DESBOIS MICHEL; DISDIER CAMILLE 权利人:RHONE POULENC SPEC CHIM 摘要:A process for the stimulaneous halogenation and fluorination of aromatic derivatives substituted by at least one group containing a halogenoalkyl unit. The aromatic derivative is reacted with the halogen in liquid hydrofluoric acid. The products obtained are useful as intermediates for the synthesis of compounds having a plant-protecting or pharmaceutical activity.
专利号:WO-2011107998-A1 优先权日:2010-03-03 标题 :Process for synthesis of fipronil
[参考文献]: R Y Yih, Et Al. New Potent Diphenyl Ether Herbicides. J Agric Food Chem. 1975 May-Jun;23(3):592-3.
合成参考文献
摘要:National Technical Information Service., OTS0526717 摘要:National Technical Information Service., OTS0526715 摘要:Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. 1 摘要:ITC/USEPA; Information Review #346 (Draft) 3,4-Dichlorobenzotrifluoride p.13 (1983) 摘要:Ashford, R.D. Ashford's Dictionary of Industrial Chemicals. London, England: Wavelength Publications Ltd., 1994., p. 284