CAS: 3107-33-3; (3-(Trifluoromethyl)Phenyl)Hydrazine Hydrochloride

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CAS号110821-29-9 5-氨基-1-[5-(氟甲基)... | CAS号103986-06-7 2,3-二甲基-1H-吲哚-6-羧酸 | CAS号66000-40-6 4,5-dihydro-1-[...

间氨基三氟甲苯置于盐酸,Sodium Nitrite,Tin(Ll) Chloride体系中,用 水 用作溶剂,化学反应生成3-(三氟甲基)苯肼盐酸盐
参考文献:作为琥珀酸脱氢酶抑制剂的新型氨基环丁烷甲酸衍生物的发现
标题:作为琥珀酸脱氢酶抑制剂的新型氨基环丁烷甲酸衍生物的发现
摘要:构象限制开关概念已被采用作为药物结构优化的主要工具,以扩大化学结构范围并提高针对特定蛋白质的治疗活性.与阳性对照啶酰菌胺相比,以此方式生产的几种1-氨基环丁烷甲酸衍生物在体外表现出令人满意的抗真菌活性.体外抗真菌试验表明,化合物a21对立枯丝核菌( R.S.,Ec 50 = 0.03 Mg/l)和灰葡萄孢( B.C.,Ec 50 = 0.04 Mg/l)具有相当甚至更高的抗真菌活性.Fluxapyroxad(r.S.,Ec 50 = 0.02 Mg/l;B.C.,Ec 50 = 0.20 Mg/l)和啶酰菌胺(r.S.,Ec 50 = 0.29 Mg/ L;B.C.,Ec )50 = 0.42 毫克/升).此外,成功筛选到的化合物a20对猪sdh具有非常好的抑制活性,其ic 50值为3.73 μm,与fluxapyroxad(ic 50 = 3.76 μm)相比具有相当的药效.使用 Sem
Doi:10.1021/acs.Jafc.3C01429

专利信息

专利号:US-11040938-B2
优先权日:2016-07-27
标 题 :Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts
发明人：MA BING; PAN SHUAI
权利人:SHANGHAI HYBRID—CHEM TECH; SHANGHAI HYBRID CHEM TECH
摘要:The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.

专利号:US-2019152896-A1
优先权日:2016-07-27
标题 :Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts

专利号:CN-107663161-B
优先权日:2016-07-27
标题:A kind of continuous flow synthesis process of phenylhydrazine salt and substituted phenylhydrazine salt

专利号:CN-107663161-A
优先权日:2016-07-27
标 题 :A kind of continuous flow synthesis process of phenylhydrazine salt and substituted phenylhydrazine salt