CAS: 298-59-9; Methylphenidate Hydrochloride

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CAS号113-45-1 匹普鲁多 | CAS号113-45-1 匹普鲁多

📜哌甲酯置于盐酸体系中,用 水,异丙醇 用作溶剂,化学反应 1.5H,以78.9%的收率获得盐酸哌甲酯
参考文献:Process For The Preparation Of Methylphenidate And Pharmaceutical Salts Thereof
标题:Process For The Preparation Of Methylphenidate And Pharmaceutical Salts Thereof
摘要:本发明涉及一种改进的甲基苯二甲酸酯的制备方法,包括立体异构体,立体异构体混合物和其药用可接受盐,更具体地说,是甲基苯二甲酸酯的硫酸盐和盐酸盐,双左旋甲基苯二甲酸酯和右旋甲基苯二甲酸酯.还公开了从上述描述的过程中去除或减少杂质的方法.

专利信息

专利号:US-9475770-B2
优先权日:2010-12-17
标 题 :Low-temperature synthesis of methylphenidate hydrochloride
发明人：HUNTLEY C FREDERICK M; KATAISTO ERIK WAYNE; LA LUMIERE KNICHOLAUS DUDLEY; REISCH HELGE ALFRED
权利人:HUNTLEY C FREDERICK M; KATAISTO ERIK WAYNE; LA LUMIERE KNICHOLAUS DUDLEY; REISCH HELGE ALFRED; RHODES TECH
摘要:The present invention describes a process for the preparation of methylphenidate hydrochloride. The process involves the esterification of ritalinic acid and methanol in the presence of an acid catalyst at a low temperature. The process may optionally involve the addition of an orthoester.

专利号:CA-2822016-C
优先权日:2010-12-17
标题:Low-temperature synthesis of methylphenidate hydrochloride

专利号:CA-2822016-A1
优先权日:2010-12-17
标题:Low-temperature synthesis of methylphenidate hydrochloride

专利号:JP-2011518154-A
优先权日:2008-04-16
标 题:A useful process for the synthesis of (R) -1- {2- [4 '-(3-methoxypropane-1-sulfonyl) -biphenyl-4-yl] -ethyl} -2-methyl-pyrrolidine

专利号:US-2015038720-A1
优先权日:2010-12-17
标 题:Low-Temperature Synthesis of Methylphenidate Hydrochloride

专利号:EP-2651892-B1
优先权日:2010-12-17
标题:Low-temperature synthesis of methylphenidate hydrochloride