专利号:US-11548898-B2 优先权日:2017-07-06 标题 :Synthesis of halichondrins 发明人:KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI 权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD 摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).
专利号:US-7897135-B2 优先权日:2004-09-27 标 题 :Carbon combustion synthesis of oxides 发明人:MARTIROSYAN KAREN S; LUSS DAN 权利人:UNIV HOUSTON 摘要:The present invention is generally directed to a novel, economic synthesis of oxide ceramic composites. Methods of the present invention, referred to as carbon combustion synthesis of oxides (CCSO), are a modification of self-propagating high-temperature synthesis (SHS) methods in which the heat needed for the synthesis is generated by combustion of carbon in oxygen rather than that of a pure metal. This enables a more economic production of the ceramic material and minimizes the presence of intermediate metal oxides in the product. The reactant mixture generally comprises at least one oxide precursor (e.g., a metal or non metal oxide, or super oxide, or nitride, or carbonate, or chloride, or oxalate, or halides) as a reactant, but no pure metal. Pure carbon in the form of graphite or soot is added to the reactant mixture to generate the desired heat (upon ignition). The mixture is placed in a reactor and exposed to gaseous oxygen. The high-temperature exothermic reaction between the carbon and oxygen generates a self-sustaining reaction in the form of a propagating temperature wave that causes a reaction among the reactants. The reaction proceeds rapidly following ignition, and the final product comprises simple and/or complex oxides of elements present in the oxide precursor(s). CCSO also enables synthesis of oxides that cannot be produced by conventional SHS, such as when the pure metal is pyrophoric (such as Li or La) or such as when it melts at room temperature (e.g., Ga) or such as the combustion heat of the metal is relatively low.
专利号:US-2021053913-A1 优先权日:2019-08-22 标题 :Process for the Synthesis of Fluorinated Conductive Salts for Lithium Ion Batteries 发明人:ZHOU CHANGYUE; DU HONGJUN; WU WENTING 权利人:FUJIAN YONGJING TECH CO LTD 摘要:The invention relates to a new process for the synthesis of fluorinated conductive salts for lithium ion batteries (Li-ion batteries). The said fluorinated conductive lithium ion (Li-ion) battery salts of interest in the framework of the present inventions synthesis process, for example, are Li-ion salts such as LiFSI (lithium bis-(fluoromethanesulfonlyl) imide), LiTFSI (lithium bis-(trifluormethanesulfonlyl) imide), and LiTFSFI (lithium trifluoromethanesulfonylfluorosulfonyl imide), with the formulas as displayed in the Table I herein below. LiFSI, LiTFSI and LiFSTFSI are the most promising conducting salts for Lithium ion batteries and essential for future electromobility.
专利号:US-7714063-B2 优先权日:2007-11-15 标 题 :Solid support for Fmoc-solid phase synthesis of peptides 发明人:SRIVASTAVA KRIPA SHANKER; DAVIS MATTHEW RYAN 权利人:MALLINCKRODT INC 摘要:The present invention provides compositions and processes for the solid phase synthesis of polypeptides. In particular, the present invention provides solid supports and processes for preparing solid supports for the synthesis of polypeptides.
专利号:US-3944619-A 优先权日:1976-02-20 标 题 :Synthesis of d-2-amino-1-butanol 发明人:SINGH BALWANT 权利人:AMERICAN CYANAMID CO 摘要:D-2-Amino-1-butanol, for the synthesis of ethambutol hydrochloride, d,d'-2,2'-(ethylenediimino)di-1-butanol dihydrochloride, is produced in high purity and good yields by the reaction of butene-1, a nitrile, preferably an excess of acetonitrile, and chlorine to form N-[1-(chloromethyl)propyl]acetimidoyl chloride which is hydrolyzed to dl-2-amino-1-butanol, which can be isolated as the hydrochloride, or free base, or a mixture, resolved with L(+)- tartaric acid and the d-2-amino-1-butanol reacted with ethylene dichloride and then hydrochloric acid to form ethambutol hydrochloride. A minimum of by-products which are conveniently split out permits the economical synthesis of a pharmaceutical grade product.
专利号:US-2014264194-A1 优先权日:2013-03-18 标 题:In-Situ Synthesis of Multi-Core Core Electoconductive Powders 发明人:MICHAELS EMILY W; MILLIGAN DEANNA; MORRIS DAVID 权利人:MILLIKEN & CO 摘要:This invention relates to the in-situ synthesis of multi-core electroconductive powders. The multi-core ECPs of the present invention are made using an in-situ synthesis method which eliminates the need for combining mixtures of various types of single-core ECPs in order to achieve the desired end-use product. The multi-core ECPs described herein exhibit very little coloration. They also exhibit low electrical resistivity and contain reduced amounts of antimony.
[参考文献]: Bikramjit Basu, Et Al. Biocompatibility Property Of 100% Strontium-Substituted Sio2 -Al2 O3 -P2 O5 -Cao-Caf2 Glass Ceramics Over 26 Weeks Implantation In Rabbit Model: Histology And Micro-Computed Tomography Analysis. J Biomed Mater Res B Appl Biomater. 2015 Aug;103(6):1168-79. [参考文献]: Debabrata Rautaray, Et Al. Biological Synthesis Of Strontium Carbonate Crystals Using The Fungus Fusarium Oxysporum. Langmuir. 2004 Aug 3;20(16):6827-33. [参考文献]: K Sahner, Et Al. Modeling Of Hydrocarbon Sensors Based On P-Type Semiconducting Perovskites. Phys Chem Chem Phys. 2007 Feb 7;9(5):635-42. [参考文献]: M Sadeghi, Et Al. (86)Y Production Via (86)Sr(P,N) For Pet Imaging At A Cyclotron. Appl Radiat Isot. 2009 Jul-Aug;67(7-8):1392-6. [参考文献]: M Sadeghi, Et Al. Radiochemical Studies Relevant To 86Y Production Via 86Sr(P,N)86Y For Pet Imaging. Appl Radiat Isot. 2009 Jan;67(1):7-10.
合成参考文献
参考文献:10.1007/s11671-008-9129-1 摘要:Marques A, Leite E, Varela J, Longo E. Effect of Variations in Annealing Temperature and Metallic Cations on Nanostructured Molybdate Thin Films. Nanoscale Research Letters. 2008 Apr 29;3(4):152. doi: 10.1007/s11671-008-9129-1.