CAS: 1501-05-9; 5-Oxo-5-Phenylpentanoic Acid

相似化合物

1501-04-8 833-85-2 4144-62-1

上下游产品

CAS号825-54-7 1-苯基环戊烯 | CAS号53715-97-2 5,5'-氧双(5-氧代戊酸) | CAS号23253-31-8 1-phenylcyclope... | CAS号108-55-4 戌二酸酐 | CAS号71-43-2 苯 | CAS号80706-60-1 1-oxaspiro[2.2]... | CAS号72157-46-1 2-Phenyl-cyclop... | CAS号80706-73-6 2-benzoylcyclob... | CAS号1198-34-1 Cyclopentanone,... | CAS号1011-61-6 1,5-Pentanediol... | CAS号939-52-6 4-氯-1-羰基-1-苯基丁烷 | CAS号20371-41-9 5-Phenylpentano... | CAS号826-73-3 1-苯并环庚酮 | CAS号20795-53-3 3-苯基环己酮 | CAS号2270-20-4 5-苯基戊酸 | CAS号73172-56-2 ETHYL 5-OXO-5-P... | CAS号16015-12-6 2-phenyl-3,4-di... | CAS号3350-92-3 5-phenylpent-4-... | CAS号17851-47-7 4-(2-phenyl-1,3...

Dl-扁桃酸甲酯置于sodium Hydroxide,(Nme4)*2H2O*ch3Cn (L = Ortho-Phenylenebis(N'-Methyloxamidate)),氧气,特戊醛,Lithium Diisopropyl Amide体系中,用 乙腈 用作溶剂,化学反应 3.0H,反应生成4-苯甲酰基丁酸
参考文献:Catalytic Aerobic Oxidative Decarboxylation Of α-Hydroxy-Acids. Methyl Mandelate As A Benzoyl Anion Equivalent
标题:Catalytic Aerobic Oxidative Decarboxylation Of α-Hydroxy-Acids. Methyl Mandelate As A Benzoyl Anion Equivalent
摘要:The Monomeric Square-Planar Cobalt(III) Complex Of Bis-N,N'-Disubstituted Oxamides Catalyses The Oxidative Decarboxylation Of Alpha-Hydroxy Acids With Molecular Oxygen/pivalaldehyde With Very Good Yields. This Reaction Offers An Interesting Alternative In The Use Of Methyl Mandelate As A Convenient Benzoyl Anion Equivalent. (C) 1998 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0040-4039(98)00482-1

专利信息

专利号:US-2022356182-A1
优先权日:2009-03-27
标题 :Inhibitors of hepatitis c virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-2005250961-A1
优先权日:2002-06-05
标题:Process for the preparation of 4-(4-fluorobenzoyl) butyric acid
发明人：PULLA REDDY M
权利人:PULLA REDDY M
摘要:The present invention provides an improved process for the preparation of 4-(4-Fluorobenzoyl)butyric acid of formula (I), which is prepared on a commercial scale using normal quality fluorobenzene (benzene content 300-700 ppm) with the desfluoro analogue impurity at an acceptable level (less than 0.1% by HPLC). The 4-(4-Fluorobenzoyl)butyric acid has the formula (I) is a key raw material for the synthesis of anti-hyperlipoproteinemetic drug ezetimibe.

专利号:US-11053243-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOIL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:WO-03104180-A1
优先权日:2002-06-05
标题 :Process for the preparation of 4-(4-fluorobenzoyl) butyric acid
发明人：PULLA REDDY MUDDASANI
权利人:NATCO PHARMA LTD; VENKAIAH CHOWDARY NANNAPANENI; PULLA REDDY MUDDASANI
摘要:The present invention provides an improved process for the preparation of 4-(4-Fluorobenzoyl)butyric acid of formula (I), which is prepared on a commercial scale using normal quality fluorobenzene (benzene content 300-700ppm) with the desfluoro analogue impurity at an acceptable level (less than 0.1 % by HPLC). The 4-(4-fluorobenzoyl)butyric acid has the formula (I) is a key raw material for the synthesis of anti-hyperlipoproteinemetic drug ezetimibe.

专利号:US-9090661-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; MCCAULEY JOHN A; LUDMERER STEVEN W; LIU KUN; VACCA JOSEPH P; WU HAO; HU BIN; SOLL RICHARD; SUN FEI; WANG XINGHAI; YAN MAN; ZHANG CHENGREN; ZHENG MINGWEI; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.