专利号:US-2024218014-A1 优先权日:2022-11-21 标 题:Synthesis of a cyclic peptide 发明人:BAUR PIUS BRUNO; CLEATOR EDWARD; DENIAU GILDAS; EISELE FRANK; FLÖGEL OLIVER; HUSTE ANJA; KEHL MARCEL ROMAN; LÖWENECK MARKUS; SILVA ROLANDO RAVELO; VORBERG RAFFAEL 权利人:JANSSEN PHARMACEUTICA NV 摘要:Processes for performing peptide synthesis, particularly for cyclic peptide synthesis are generally described. Reaction intermediates of the peptide synthesis are also described.
专利号:US-2013165350-A1 优先权日:2011-12-22 标 题:Surface linkers for array synthesis 发明人:KUIMELIS ROBERT; MCGALL GLENN; PAO DEXTER; CHEN ZIHUI; AXELROD TREVOR 权利人:KUIMELIS ROBERT; MCGALL GLENN; PAO DEXTER; CHEN ZIHUI; AXELROD TREVOR; AFFYMETRIX INC 摘要:The present invention provide several methods of derivatizing a surface of a support with one or more linkers thus providing a suitable platform for synthesis of a polymer array, particular a nucleic acid array. Some methods derivatize a surface with a self-assembled monolayer (SAM) of a linker. The SAM confers advantages of hydrolytic stability, broad compatibility with synthesis and detection chemistries, and reduced emergence of latent functional groups during polymer array synthesis. Substrates can also be derivatized with multi-layers of SAMs providing greater hydrolytic stability. Substrates can also be derivatized by synthesizing a linker in situ on the substrate by atom transfer radical polymerization of functional and functional monomers. Appropriate selection of monomers reduces emergence of latent functional groups in subsequent array synthesis.
专利号:US-2012277444-A1 优先权日:2011-04-27 标 题:Synthesis of hydroxyalkyl amides from esters 发明人:MAHADEVAN SHIVKUMAR; VENKATASUBBAN KUNISI 权利人:MAHADEVAN SHIVKUMAR; VENKATASUBBAN KUNISI 摘要:Hydroxyamides are synthesized from esters. A process of making hydroxyalkyl amides comprises: reacting an ester with a hydroxyalkyl amine having the formula H 2 N—R 3 —OH wherein R 3 is a substituted or unsubstituted C2 to C5 alkyl, in the presence of a catalyst in an anhydrous solution to form the hydroxyalkyl amides. Monomers suitable for formation of polymeric articles can utilize these hydroxyamides.
专利号:US-2017266353-A1 优先权日:2014-05-13 标 题:Bioadhesive compounds and methods of synthesis and use 发明人:MURPHY JOHN L; RADANO CHRISTOPHER P; DALSIN JEFFREY L; KOEPSEL JUSTIN T 权利人:DSM IP ASSETS BV 摘要:Synthesis methods for creating polymeric compounds comprising phenyl derivatives (PD), or PDp i.e., polymers modified with PD, with desired surface active effects are described. The polymer backbone of PDp has structural or performance features that can be tailored to control physical properties of PDp, allowing it to be useful for different applications i.e., tissue adhesives or sealants, adhesion promoting coatings, and antifouling coatings.
专利号:US-2005043560-A1 优先权日:2000-06-19 标题:Novel beta-hydroxyamides 发明人:MANEA MIRCEA; PETERSSON CECILIA 权利人:PERGO EUROP AB 摘要:Disclosed is a novel β-hydroxylamide of general formula n n nwherein R 1 is a linear or branched aliphatic hydrocarbon group optionally comprising one or more ether and/or ester units, such as a group derived from at least one hydroxyfunctional n ncompound, R 2 is a linear or branched aliphatic and/or aromatic hydrocarbon group, such as a group derived from at least one carboxyfunctional compound or at least one anhydride halide or ester of a carboxyfunctional compound, R 3 is N-alkyl or N-cycloalkyl for instance derived from at least one alkanolamine, and wherein m is an integer and at least 1 and n is an integer and at least 2, In a further aspect the present invention refers to a process for synthesis of said β-hydroxyamide. The process comprises the Steps of (i) subjecting a di, tri or polyalcohol to alcoholysis with at least one di, tri or polyalkyl ester of a di, tri or polyfunctional carboxylic acid and (ii) subjecting obtained reaction product to aminolysis with at least one alkanolamine.
专利号:US-2003195373-A1 优先权日:2000-06-19 标 题 :Novel beta-hydroxyamides 发明人:MANEA MIRCEA; PETERSSON CECILIA 摘要:Disclosed is a noble β-hydroxyamide of general formula wherein R 1 is alkyl, alkoxyalkyl or hydroxyalkoxyalkyl derived from at least one hydroxyfunctional compound, R 2 is alkyl, aryl, alkylaryl or arylalkyl derived from at least one carboxyfunctional compound or at least one anhydride, halide or ester of at least one carboxyfunctional compound, R 3 is N-alkyl or N-cycloalkyl derived from at least one alkanolamine and wherein m and n are independent integers and at least 1. In a further aspect the present refers to a process for synthesis of said β-hydroxyamide. The process comprises the Steps of (i) subjecting a di, tri or polyalcohol to alcoholysis with at least one di, tri or polyalkyl ester of a di, tri or polyfunctional carboxylic acid and (ii) subjecting obtained reaction product to aminolysis with at least one alkanolamine.
[参考文献]: Meriyem Aktas, Et Al. Enzymatic Properties And Substrate Specificity Of A Bacterial Phosphatidylcholine Synthase. Febs J. 2014 Aug;281(15):3523-41.
合成参考文献
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